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Bioss
Numéro de catalogue:
(BOSSBS-11455R-A350)
Fournisseur:
Bioss
Description:
Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to ?subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortin-like and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15431R-CY7)
Fournisseur:
Bioss
Description:
HDDC2.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15431R-A750)
Fournisseur:
Bioss
Description:
HDDC2.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9322R-CY5)
Fournisseur:
Bioss
Description:
Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8184R-CY5)
Fournisseur:
Bioss
Description:
CRELD1 is a protein composed of Epidermal growth factor-like repeats, which represent a group of cysteine-rich domains that mediate interactions between proteins of diverse function. Such domains are found in proteins that are either completely secreted or have transmembrane regions that link the protein to the cell surface.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11655R-CY3)
Fournisseur:
Bioss
Description:
The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage. Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3801R-A488)
Fournisseur:
Bioss
Description:
All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12919R-CY5)
Fournisseur:
Bioss
Description:
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8184R-A555)
Fournisseur:
Bioss
Description:
CRELD1 is a protein composed of Epidermal growth factor-like repeats, which represent a group of cysteine-rich domains that mediate interactions between proteins of diverse function. Such domains are found in proteins that are either completely secreted or have transmembrane regions that link the protein to the cell surface.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12919R-FITC)
Fournisseur:
Bioss
Description:
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9125R-A488)
Fournisseur:
Bioss
Description:
Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12148R-A647)
Fournisseur:
Bioss
Description:
Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3892R-FITC)
Fournisseur:
Bioss
Description:
Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7843R-A750)
Fournisseur:
Bioss
Description:
NUP160 is 1 of up to 60 proteins that make up the 120 MD nuclear pore complex, which mediates nucleoplasmic transport. NUP160 forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. NUP160 is involved in poly(A)+ RNA transport.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8223R-A750)
Fournisseur:
Bioss
Description:
FAM155A.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4559R-HRP)
Fournisseur:
Bioss
Description:
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta and gamma). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-Actin junction of the membrane skeleton. The cortical Actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical Actin network organization. Adducin alpha is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin alpha and Adducin gamma is ubiquitous in contrast to the restricted expression of Adducin beta . Adducin beta is expressed at high levels in brain and hematopoietic tissues, such as bone marrow in humans and spleen in mice.
UOM:
1 * 100 µl
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