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Anticorps
Numéro de catalogue:
(BOSSBS-2400R-A750)
Fournisseur:
Bioss
Description:
Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilisation of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8372R-FITC)
Fournisseur:
Bioss
Description:
E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4179R-A488)
Fournisseur:
Bioss
Description:
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8186R-CY7)
Fournisseur:
Bioss
Description:
This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4250R-A647)
Fournisseur:
Bioss
Description:
The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-14441R-A680)
Fournisseur:
Bioss
Description:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2939R-A488)
Fournisseur:
Bioss
Description:
Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-14441R-HRP)
Fournisseur:
Bioss
Description:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-14441R-A555)
Fournisseur:
Bioss
Description:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-14441R-A488)
Fournisseur:
Bioss
Description:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-10448R-CY7)
Fournisseur:
Bioss
Description:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-10448R-CY5)
Fournisseur:
Bioss
Description:
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1497R-A350)
Fournisseur:
Bioss
Description:
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1497R-A488)
Fournisseur:
Bioss
Description:
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6818R-CY3)
Fournisseur:
Bioss
Description:
Not known, though may play a role in tumor transformation or aspects of tumor progression.Tissue specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12358R-FITC)
Fournisseur:
Bioss
Description:
YKL-39 is a 390 amino acid cartilage protein that belongs to the chitinase family of chitin-fragmenting hydrolases. Highly expressed in chondrocytes (cartilage cells) and synoviocytes (fibroblastic cells that line joint cavities), YKL-39 binds glycan structures with high affinity. Although related to bacterial chitinases, YKL-39 lacks the characteristic glutamate active site and, thus, does not have enzymatic chitinase activity. Patients affected with rheumatoid arthritis (RA) have autoimmunity against YKL-39, suggesting that YKL-39 is involved in osteoarthritic and/or rheumatoid joint disease. Additionally, YKL-39 is upregulated in early degenerative cartilage diseases (such as RA) and may be a marker of chondrocyte activation in these autoimmune conditions.
UOM:
1 * 100 µl
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