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Anticorps
Numéro de catalogue:
(BOSSBS-4015R)
Fournisseur:
Bioss
Description:
IRGM belongs to a family of interferon-gamma inducible GTPases, belonging to the GTPase superfamily, and are selectively induced by IFN-gamma or bacterial lipopolysaccharide (LPS) stimulation. IRGM is primarily expressed in all cells derived from B-cell lineages, and is highly expressed in macrophages following IFN-gamma stimulation. IRGM has been shown to be required for host defences against a broad range of intracellular pathogens. Specifically, IRGM deficient mice show defects with intracellular microbial killing, phagosome maturation and autophagy. More recently IRGM has been shown to inhibit baseline hematopoietic proliferation and is required for a normal hematopoietic stem cell response to chemical and infectious stimuli.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4035R)
Fournisseur:
Bioss
Description:
The SENP3 protease releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. It deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2466R)
Fournisseur:
Bioss
Description:
Siglec 7 is a member of the Siglec (sialic acid-binding immunoglobulin like lectin) subgroup of the immunoglobulin superfamily. Siglec 7 is able to mediate high levels of sialic acid-dependent binding to human erythrocytes and soluble sialoglycoconjugates. Addition of anti-Siglec 7 to haematopoietic cell cultures leads to reduced cell growth and prevents the development of dendritic cells. Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression can be found in tissues like the placenta, liver, lung, spleen, and peripheral blood leukocytes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2370R)
Fournisseur:
Bioss
Description:
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4022R)
Fournisseur:
Bioss
Description:
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
UOM:
1 * 100 µl
Numéro de catalogue:
(BWRLBS2478)
Fournisseur:
Bioworld Technology
Description:
Synthetic peptide, corresponding to amino acids 50-100 of Human Ephrin-A5.
UOM:
1 * 1 EA
Numéro de catalogue:
(BWRLBS2465)
Fournisseur:
Bioworld Technology
Description:
Synthetic peptide, corresponding to amino acids 200-240 of Human UDG.
UOM:
1 * 1 EA
Numéro de catalogue:
(BWRLBS2488)
Fournisseur:
Bioworld Technology
Description:
Synthetic peptide, corresponding to amino acids 98-149 of Human Dok-6.
UOM:
1 * 1 EA
Numéro de catalogue:
(BWRLBS2512)
Fournisseur:
Bioworld Technology
Description:
Synthetic peptide, corresponding to amino acids 50-100 of Human 14-3-3 gamma.
UOM:
1 * 1 EA
Numéro de catalogue:
(BWRLBS2481)
Fournisseur:
Bioworld Technology
Description:
Synthetic peptide, corresponding to amino acids 120-170 of Human Sox8.
UOM:
1 * 1 EA
Numéro de catalogue:
(BWRLBS2513)
Fournisseur:
Bioworld Technology
Description:
Synthetic peptide, corresponding to amino acids 851-900 of Human ABL1.
UOM:
1 * 1 EA
Numéro de catalogue:
(BOSSBS-0112R-CY7)
Fournisseur:
Bioss
Description:
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13091R-CY7)
Fournisseur:
Bioss
Description:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1875R-A750)
Fournisseur:
Bioss
Description:
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0921R-A680)
Fournisseur:
Bioss
Description:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterised by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2773R-A555)
Fournisseur:
Bioss
Description:
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity (By similarity).
UOM:
1 * 100 µl
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