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Ace+Method+Development+Kits
Numéro de catalogue:
(BOSSBS-13203R-HRP)
Fournisseur:
Bioss
Description:
FOXI1 is a member of the FOX family of transcription factors. The FOX family is a large group of proteins (consisting of at least 43 members) that share a common DNA binding domain termed winged-helix or forkhead domain. FOX transcription factors play important roles in development, differentiation, aging and hormone responsiveness. Localizing to the nucleus, FOXI1 functions as a transcription factor. Mice with mutated forms of FOXI1 show defects in ear development, implying that FOXI1 plays a significant role in the developmental pathway of ears and, in particular, the cochlea and vestibulum. FOXI1 is an upstream transcription regulator of Pendrin (a protein associated with deafness), suggesting a role for FOXI1 in the pathogenesis of Pendred syndrome (PS), a condition of nonsyndromic hearing loss and enlarged vestibular aqueduct (EVA).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11599R-A488)
Fournisseur:
Bioss
Description:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11599R-A555)
Fournisseur:
Bioss
Description:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11599R-A350)
Fournisseur:
Bioss
Description:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11587R-A750)
Fournisseur:
Bioss
Description:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11111R-A555)
Fournisseur:
Bioss
Description:
Protocadherins are a subfamily of cadherins, a large group of related glycoproteins that mediate calcium-dependent cell-to-cell adhesion via a homophilic mechanism. Involved in a variety of functions, protocadherins help to regulate neural development and synapse formation. PCDH1 is a 1,026 amino acid single-pass type I membrane protein that contains seven cadherin domains and is a member of the protocadherin family. Localized to cell-cell and cell-matrix boundaries and expressed at high levels in brain and neuro-glial cells, PCDH1 is thought to be involved in cell adhesion and cell-cell interactions and may play a role in neuronal development. PCDH1 contains a C-terminal cytoplasmic region, an extracellular region and a transmembrane region, and is expressed as two isoforms due to alternative splicing events.
UOM:
1 * 100 µl
Numéro de catalogue:
(101814R)
Fournisseur:
VWR Chemicals
Description:
Ether de pétrole, 100…120 °C, AnalaR NORMAPUR® ACS pour analyses
UOM:
1 * 2,5 L
Fournisseur:
Avantor
Description:
Les colonnes Avantor® ACE® C4-300 offrent une grande reproductibilité et une longue durée de vie. Ces colonnes en acier inoxydable sont disponibles dans une large gamme de tailles de particules et de dimensions, du capillaire au préparatif.
Numéro de catalogue:
(BOSSBS-0709R-CY5.5)
Fournisseur:
Bioss
Description:
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11435R-CY7)
Fournisseur:
Bioss
Description:
Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11892R-A555)
Fournisseur:
Bioss
Description:
Neuron navigator 2 (NAV2), also known as RAINB1 (retinoic acid inducible in neuroblastoma 1), POMFIL2 (pore membrane and/or filament-interacting-like protein 2), HELAD1 (helicase APC down-regulated 1), unc53H2 or steerin-2, is a 2,488 amino acid nuclear protein that plays a role in the development of sensory organs. Existing as thirteen alternatively spliced isoforms, Neuron navigator 2 displays 3' to 5' helicase activity and exonuclease activity and participates in the catalysis of ATP to ADP. Neuron navigator 2 is highly expressed in the nervous system of developing embryos and colon carcinomas, as well as in liver, brain and kidney. Lower levels of expression are found in lung, thyroid, spinal cord, heart, placenta and mammary gland. Neuron navigator 2 belongs to the Nav/unc-53 family and contains one CH (calponin-homology) domain.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1083R-A647)
Fournisseur:
Bioss
Description:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9550R)
Fournisseur:
Bioss
Description:
The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. There are a number of conditions related to an unsual number and combination of sex chromosomes being inherited. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions which affect males more frequently as males carry a single X chromosome. The CXorf56 gene product has been provisionally designated CXorf56 pending further characterization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13185R-CY5)
Fournisseur:
Bioss
Description:
The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. In mice, the limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of proteins known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing Actin filament assembly. Formins co-localize with the actin cytoskeleton and can translocate into the cell cytosol and into the nucleus in an HGF-dependent manner. Vertebrate nuclear formins can control polarizing activity in limb buds through establishment of a Sonic hedgehog/FGF-4 feedback loop. Deficiency mutations at the mammalian ld locus lead to profound developmental defects in limb and kidney formation. The human Formin 1 and 2 genes map to chromosome 15q13.3 and 1q43, respectively.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0352R-CY5.5)
Fournisseur:
Bioss
Description:
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
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