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Masterflex+Single-use+Flow+Sensor
Fournisseur:
Merck Millipore (Novagen)
Description:
Clonables™ 2X ligation premix is a single solution containing optimised concentrations of T4 DNA ligase, buffer, stabiliser, and cofactors needed for efficient ligation of any type of compatible DNA ends.
Numéro de catalogue:
(WHEA851346)
Fournisseur:
DWK Life Sciences
Description:
Nozzle protection filters for 10 ml macropipettors, PP fibers, Acura®
UOM:
1 * 100 ST
Fournisseur:
HIRSCHMANN
Description:
Certificat d'étalonnage DKD pour labopette® 12 canaux, 5 - 250 μl
Numéro de catalogue:
(ANTIA83073-100)
Fournisseur:
ANTIBODIES.COM
Description:
Goat polyclonal antibody to PLA2R1 for ELISA and flow cytometry with samples derived from human.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ANTIA83229-100)
Fournisseur:
ANTIBODIES.COM
Description:
Goat polyclonal antibody to LARP2 for ELISA, IF and flow cytometry with samples derived from human.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ANTIA286041-100)
Fournisseur:
ANTIBODIES.COM
Description:
Goat polyclonal antibody to POU4F2 for ELISA and Flow cytometry with samples derived from human.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(AATB17631)
Fournisseur:
AAT BIOQUEST INC
Description:
Portelite™ fluorimetric total nucleic acid quantitation kit is optimised for measuring the total amounts of nucleic acids with CytoCite™ or Qubit® fluorometers.
UOM:
1 * 200 Tests
New Product
Fournisseur:
Agilent
Description:
The stainless steel 7725i and PEEK 9725i manual injection valves are suitable for large sample volumes, high flow rates and preparative columns sized 10 to 100 mm in diameter.
Numéro de catalogue:
(BOSSBS-4114R-A488)
Fournisseur:
Bioss
Description:
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4114R-A555)
Fournisseur:
Bioss
Description:
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
UOM:
1 * 100 µl
Numéro de catalogue:
(ANTIA277866-100)
Fournisseur:
ANTIBODIES.COM
Description:
Mouse monoclonal [BTN399] antibody to Biotin for Flow Cytometry, IF, WB and IHC-P.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(BSBTPB9246)
Fournisseur:
BosterBio
Description:
Polyclonal antibody for TNF ALPHA/TNF detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Mouse. TNF ALPHA/TNF information: Molecular Weight: 25896 MW; Subcellular Localization: Cell membrane; Single-pass type II membrane protein.
UOM:
1 * 1 EA
Numéro de catalogue:
(AATB16301)
Fournisseur:
AAT BIOQUEST INC
Description:
DAX-J2™ Red is a new nitric oxide (NO) sensor recently developed by AAT Bioquest.
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(PRSI92-469)
Fournisseur:
ProSci Inc.
Description:
V-set and transmembrane domain-containing protein 1 is a single-pass membrane protein. VSTM1 Contains 1 Ig-like V-type domain, in humans is encoded by the VSTM1 gene. It expressed on myeloid (neutrophils, eosinophils and monocytes) but not on lymphoid cells. It behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cells (TH17). Inhibitory immune receptor involved in the regulation of phagocytes.
UOM:
1 * 50 µG
Fournisseur:
WINKLER GMBH
Description:
Sondes de température et câbles de compensation, +250…+500 °C, Ø×L: 4×50 mm
Numéro de catalogue:
(BOSSBS-2771R-A350)
Fournisseur:
Bioss
Description:
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2.
UOM:
1 * 100 µl
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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