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Masterflex+Single-use+Flow+Sensor
Numéro de catalogue:
(PRSI91-885)
Fournisseur:
ProSci Inc.
Description:
Interferon alpha/ beta Receptor 2 (IFN- alpha/ beta R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN- alpha/ beta R1 to form the signaling receptor complex for the family of alpha and beta IFN subtypes. By alternative splicing, IFN- alpha/ beta R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN- alpha/ beta R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN- alpha/ beta R1, resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets, IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase, JAK1. Isoform 1 also interacts with the transcriptional factors, STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.
UOM:
1 * 50 µG
Numéro de catalogue:
(181-0305)
Fournisseur:
NRG DEVELOPMENTS
Description:
Suction operated siphon pump.
UOM:
1 * 1 ST
Fournisseur:
VACUUBRAND
Description:
This VARIO® chemistry pumping unit optimizes vacuum conditions automatically by precisely and continuously adjusting the diaphragm pump´s motor speed. Thanks to the motor speed control the pump operates only when vacuum is needed, saving energy and reducing maintenance.
Numéro de catalogue:
(662-2016)
Fournisseur:
EUTECH
Description:
Ce testeur étanche est conçu avec une technologie de microprocesseur avancée pour vous donner jusqu'à ±2 mV de précision sur une large plage de mesure. Capteur à double jonction remplaçable par l'utilisateur avec une large bande en platine qui offre des résultats très précis, même dans des environnements humides et exigeants. Idéal pour les mesures dans les réservoirs de rinçage de galvanoplastie, les piscines, l'eau potable, les eaux usées, le traitement chimique, la destruction du cyanure et la réduction du chromate.
UOM:
1 * 1 ST
Numéro de catalogue:
(PRSI90-414)
Fournisseur:
ProSci Inc.
Description:
CD152 (CTLA-4) and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally
homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
UOM:
1 * 500 µG
Numéro de catalogue:
(441-0344)
Fournisseur:
IKA
Description:
Sonde de température, recouverte
UOM:
1 * 1 ST
Numéro de catalogue:
(BOHLP1790-20)
Fournisseur:
Bohlender
Description:
Total immersion PTFE probe (class A, PRT 100), with white PTFE-coated cable.
UOM:
1 * 1 ST
Fournisseur:
Mettler - Toledo
Description:
Ces appareils mesurent le pH et l'ORP avec des sondes classiques et mesurent également le pH avec la technologie ISFET. Ils sont efficaces dans les applications complexes et les tâches de mesure de routine dans les laboratoires, et répondent aux exigences strictes des marchés réglementés.
Fournisseur:
HAMILTON BONADUZ
Description:
Ces capteurs d'oxygène électrochimiques sont dédiés aux applications d'exigence élevée en termes d'hygiène (industrie pharmaceutique, biotechnologie, production d'aliments et de boissons). Ils sont équipés d'une membrane approuvée par la FDA pour une les processus d'hygiène. Ils sont capables de résister à la stérilisation à la vapeur, au processus d'autoclave et aux nettoyages en place.
Numéro de catalogue:
(115-1982)
Fournisseur:
Essity
Description:
Ces distributeurs de savon offrent un design moderne et élégant dans vos sanitaires.
UOM:
1 * 1 ST
Fournisseur:
SciLabware
Description:
PYREX®, borosilicate glass, medium neck.
Numéro de catalogue:
(PRSI5125)
Fournisseur:
ProSci Inc.
Description:
MATN1 Antibody: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN1 is composed of two Willebrand Factor A (vWFA) domains separated by one EGF-like domain, whereas MATN3 is composed of a single N-terminal vWFA domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that the MATN1 promoter region was associated with both susceptibility and disease progression in Adolescent idiopathic scoliosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-415)
Fournisseur:
ProSci Inc.
Description:
CD152 [CTLA-4] and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD152 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD152 and CD28 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD152 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. CD152 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CD152 transcripts have since been found in both Th1 and Th2, and CD4 + and CD8 + T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4 + T cells and 50% of CD8 + T cells and is down regulated upon T cell activation, CD152 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CD152 and CD28 can bind to the same ligands, CD152 binds to B71 and B72 with 20-100-fold higher affinity than CD28.
UOM:
1 * 1 EA
Fournisseur:
Bohlender
Description:
These temperature probe with two independent thermocouples in one PTFE-encapsulated stainless steel tube (1,4571) for parallel temperature measurement in aggressive liquids.
Numéro de catalogue:
(PRSI5127)
Fournisseur:
ProSci Inc.
Description:
MATN3 Antibody: Matrilins (MATNs) are a family of non-collagenous extra-cellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain whereas MATN1 is composed of two vWFA domains separated by one EGF-like domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-392)
Fournisseur:
ProSci Inc.
Description:
CD28 and CTLA-4 together with their ligands, CD80 (B7-1) and CD86 (B7-2), constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD28 and CTLA-4 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD28 and CTLA-4 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2 and mouse chromosome 1. Mouse CD28 is expressed constitutively on virtually 100% of mouse T cells and on developing thymocytes. Cell surface expression of mouse CD28 is downregulated upon ligation of CD28 in the presence of PMA or PHA. In contrast, CTLA-4 is not expressed constitutively but is upregulated rapidly following T cell activation and CD28 ligation. Cell surface expression of mouse CTLA-4 peaks approx.y 48 hours after activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28. CD28/B7 interaction has been shown to prevent apoptosis of activated T cells via the upregulation of bcl-XL. CD28 ligation has also been shown to regulate Th1/Th2 differentiation.
UOM:
1 * 200 µG
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