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Single-use+Temperature+Sensor
Numéro de catalogue:
(662-0553)
Fournisseur:
Mettler - Toledo
Description:
pH-mètre, Sensor module (Conductivity, TDS, salinity, °C), InLab781® Conductivity
UOM:
1 * 1 ST
Numéro de catalogue:
(PRSI91-339)
Fournisseur:
ProSci Inc.
Description:
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells, highly in naive T-cells and B-cells. As an inhibitory receptor, LAIR1 plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. LAIR1 plays inhibitory role independently of SH2-containing phosphatases and modulates cytokine production in CD4+ T-cells. It down-regulates IL2 and IFNG production while inducing secretion of transforming growth factor beta, also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. LAIR1 inhibits the differentiation of peripheral blood precursors towards dendritic cells. It also restrains proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI34-172)
Fournisseur:
ProSci Inc.
Description:
Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI48-682)
Fournisseur:
ProSci Inc.
Description:
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 50 µG
Fournisseur:
LONZA
Description:
Le système FlashGel™ pour ADN offre une méthode rapide pour la séparation de l'ADN et l'observation de la migration de l'ADN en temps réel. Il est constitué de cassettes d'agarose FlashGel™ DNA fermées, jetables et précoulées, ainsi que d'un appareil d'électrophorèse avec transilluminateur intégré (FlashGel™ Dock) pour la séparation et la détection.
Numéro de catalogue:
(71978-3)
Fournisseur:
Merck Millipore (Novagen)
Description:
The One Step RT-PCR Master Mix Kit allows rapid, sensitive analysis of gene expression from tissues and cells. It can replace methods for detecting and quantifying gene expression such as Northern blots,<i> in situ</i> hybridisation, dot blots, S nuclease assays and conventional two step RT-PCR. The kit utilises recombinant <i>Thermus thermophilus</i> (rTth) DNA Polymerase, which acts as both a thermostable RNA dependent DNA polymerase and a DNA dependent DNA polymerase. The rTth DNA Polymerase is provided in a 2X master mix with an antibody for antibody-mediated hot start, optimised buffer, and ultrapure deoxynucleotides. Antibody-mediated Hot Start enhances specificity of both reverse transcription and PCR. The kit enables cDNA synthesis from input RNA followed by PCR amplification of the cDNA in a single reaction, with no additional hands-on requirement for buffer changes or adding reagents. Typically, detection of a specific transcript requires only 2 hours.
UOM:
1 * 1 KIT
Numéro de catalogue:
(ENDRCPS77E-1082/0)
Fournisseur:
Endress+Hauser
Description:
Digital ISFET sensor for hygienic applications.
UOM:
1 * 1 ST
New Product
Fournisseur:
CONSORT
Description:
These combination electrodes have an epoxy body.
Numéro de catalogue:
(ELET32587-00)
Fournisseur:
Cole-Parmer
Description:
Get accurate temperature control of heating equipment in your lab.
UOM:
1 * 1 ST
Numéro de catalogue:
(PRSI26-397)
Fournisseur:
ProSci Inc.
Description:
PCDHGB1 is a single-pass type I membrane protein. It contains 6 cadherin domains. PCDHGB1 is a potential calcium-dependent cell-adhesion protein. It may be involved in the establishment and maintenance of specific neuronal connections in the brain.This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
UOM:
1 * 50 µG
Fournisseur:
EPPENDORF
Description:
Micropipette précise, simple d'emploi et de poids réduit, spécialement conçue pour des normes professionnelles élevées afin de fournir une assistance optimale dans le cadre du travail quotidien. Conception intuitive basée sur le concept Eppendorf PhysioCare® Concept éprouvé.
Numéro de catalogue:
(HEID591-61210-00)
Fournisseur:
Heidolph Instruments GmbH & Co.KG
Description:
For high-performance distillation with the best separation performance, suitable for most solvents (A1 version), also when processing foaming media (A2 version): Version with adapter for Hei-VAP Industrial with glassware of the A series (A1, A2).
UOM:
1 * 1 ST
New Product
Fournisseur:
ANSELL HEALTH CARE
Description:
Entièrement enduits, avec isolation en mousse PU pour une chaleur et un confort accrus. Finition texturée pour une préhension inégalée sur les surfaces mouillées et glissantes. Enduction en PVC solide et hydrophobe, n'absorbe pas l'eau, ne se raidit pas comme le cuir et reste souple, même à des températures négatives.
Fournisseur:
EBRO
Description:
PT1000 sensor, 100 mm wire for EBI 12-T480
Fournisseur:
DWK Life Sciences
Description:
DURAN®, verre borosilicaté 3,3, transparent, polis, sans clé
Numéro de catalogue:
(PRSI30-813)
Fournisseur:
ProSci Inc.
Description:
EGLN3 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. EGLN3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. It may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. EGLN3 promotes cell death through a caspase-dependent mechanism.
UOM:
1 * 50 µG
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