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Solid+Phase+Extraction
Numéro de catalogue:
(BOSSBS-5290R-FITC)
Fournisseur:
Bioss
Description:
Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1722R-A488)
Fournisseur:
Bioss
Description:
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4587R-HRP)
Fournisseur:
Bioss
Description:
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1827R-HRP)
Fournisseur:
Bioss
Description:
Interleukin 11 is a pleiotropic cytokine produced by mesenchymal-derived adherent cells. IL11 shares many functions of IL6 and LIF, including potentiation of megakaryocyte activity, enhancement of human myeloma cell proliferation, and enhancement of hepatic acute phase protein production.Interleukin 11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production. Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1827R-A680)
Fournisseur:
Bioss
Description:
Interleukin 11 is a pleiotropic cytokine produced by mesenchymal-derived adherent cells. IL11 shares many functions of IL6 and LIF, including potentiation of megakaryocyte activity, enhancement of human myeloma cell proliferation, and enhancement of hepatic acute phase protein production.Interleukin 11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production. Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1658R-HRP)
Fournisseur:
Bioss
Description:
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1658R-A350)
Fournisseur:
Bioss
Description:
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(ENZOBPDABS043291)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Mouse neutrophil gelatinase-associated lipocalin (NGAL; also lipocalin 2, 24p3, SIP24, uterocalin and siderocalin) belongs to the lipocalin family of proteins which bind and transport small lipophilic molecules. Following research showing 24p3 dramatically upregulated in kidney cell cultures infected with SV40, it was subsequently identified as a lipocalin. Unlike human NGAL, mouse NGAL is an acute phase protein upregulated in the liver, but like its mammalian homologues, it is upregulated and secreted by the kidney in response to ischemic or nephrotoxic injury. It is also upregulated in the involuting uterus and mammary gland.
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(BOSSBS-5218R-A680)
Fournisseur:
Bioss
Description:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5218R-HRP)
Fournisseur:
Bioss
Description:
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1981R-CY7)
Fournisseur:
Bioss
Description:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.
UOM:
1 * 100 µl
Numéro de catalogue:
(REST31829)
Fournisseur:
Restek
Description:
This contais 54 components, incorporates all phenols, for fast preparation and calibration, incorporates 'additional' extractable method 625 compounds. GC-MS method applicable to analysis of organic compounds in water and soil.
UOM:
1 * 1 Ampul
Numéro de catalogue:
(630-3553)
Fournisseur:
DISCOVER ECHO
Description:
The ECHO confocal redefines the traditional complicated confocal experience to make high resolution imaging easier.
UOM:
1 * 1 ST
Fournisseur:
Avantor
Description:
Avantor® ACE® Excel® SuperC18 columns provide high stability across an extended pH range. These stainless steel columns are ideal for use with LC/MS compatible buffers and can be used with both MeOH and MeCN mobile phases.
Fournisseur:
AMBION
Description:
Ambion® Water Saturated Phenol is supplied premixed and at pH 6.6 (pH 7.9 ± 0.2, with included buffer). Water Saturated Phenol is used in RNA and DNA extraction procedures. Preparation of phenol for use in molecular biology applications is a time-consuming and often hazardous procedure due to its toxic and corrosive nature. Ambion® premixed, quality tested, saturated phenols are ready-to-use, eliminating handling problems and offering a more convenient, safer, and easier alternative to preparing solutions from crystalline phenol.
Fournisseur:
Avantor
Description:
Avantor® ACE® Excel® C18-Amide is a uniquely designed stationary phase offering improved retention of polar compounds, enhanced phenolic resolution and alternative selectivity to C18 bonded columns. These stainless steel columns are available in a wide range of particle sizes and dimensions from capillary to preparative.
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