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Solid+Phase+Extraction
Numéro de catalogue:
(PRSI91-242)
Fournisseur:
ProSci Inc.
Description:
U6 snRNA-Associated Sm-Like Protein LSm1 (LSM1) belongs to the snRNP Sm proteins family. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which plays an important role in pre-mRNA splicing. LSM1 binds specifically to the 3-terminal U-tract of U6snRNA. LSM1 can interact with SLBP when histone mRNA is being rapidly degraded during the S phase. In addition, LSM1 is associated with cellular transformation and the progression of several malignancies including mesothelioma, lung cancer and breast cancer.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI29-012)
Fournisseur:
ProSci Inc.
Description:
SART3 is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. SART3 is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This protein is thought to be involved in the regulation of mRNA splicing.
UOM:
1 * 1 EA
Fournisseur:
VWR Collection
Description:
Revêtement en <B>PTFE</B>, fort noyau magnétique Alnico V. Surface lisse. Particulièrement efficaces pour dissoudre les solides et mélanger les sédiments en raison de leur effet récurant sur la base du récipient.
Numéro de catalogue:
(PRSI92-715)
Fournisseur:
ProSci Inc.
Description:
Alpha-2-HS-glycoprotein (AHSG) is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the Cystatin family of proteases inhibitors. It is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. AHSG is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. In addition, AHSG may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. ASHG blocks TGF-beta-dependent signalling in osteoblastic cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI30-137)
Fournisseur:
ProSci Inc.
Description:
RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI55-077)
Fournisseur:
ProSci Inc.
Description:
EHMT1, also known as EUHMTASE1, is a histone methyltransferase. This protein methylates 'Lys-9' of histone H3 in vitro. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. EHMT1 is Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in the G0/G1 transition of the cell cycle.
UOM:
1 * 400 µl
New Product
Numéro de catalogue:
(PRSI38-201)
Fournisseur:
ProSci Inc.
Description:
Interleukin 6 (IL-6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL-6 has also been implicated in regulating adipose mass.
UOM:
1 * 1 EA
Fournisseur:
AIR LIQUIDE CRYOTECHNIC
Description:
Large storage capacity for straws, cryo-vials and bags. Easy to use immediate access to products and samples. Variety of electronic options on all models.
Stainless steel construction.
Numéro de catalogue:
(PRSI79-644)
Fournisseur:
ProSci Inc.
Description:
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes By similarity. Acts as a transcriptional activator or repressor By similarity. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' By similarity. When overexpressed, promotes cells to enter into S phase and proliferation
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI55-429)
Fournisseur:
ProSci Inc.
Description:
Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.
UOM:
1 * 400 µl
New Product
Fournisseur:
Avantor
Description:
Powder. For LC and molecular biology. Lot analysis on label.
Fournisseur:
LAUDA
Description:
Les Kryomats Proline sont des cryothermostats compacts, posés au sol, équipés en série de la console de contrôle/commande. Cette console présente un écran LCD graphique rétro-éclairé, l'affichage des valeurs réelles avec une précision de 0,1/0,01 ou 0,001 °C et la possibilité d'entrer les données par le biais du curseur ou des touches de fonction. L'écran fournit des messages texte clairs et une représentation graphique des courbes de température séquentielles ; il présente un guidage par menu en quatre langues (allemand, anglais, français et espagnol). Grâce à de grandes ouvertures de bain et des volumes jusqu'à 40 litres, cette gamme convient particulièrement aux applications internes.
Numéro de catalogue:
(PRSI79-266)
Fournisseur:
ProSci Inc.
Description:
NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-κ-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-κ-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.
UOM:
1 * 1 EA
Fournisseur:
Sampling Systems
Description:
L'échantillonneur à manchon est spécialement conçu pour les grands volumes à grande profondeur.
Fournisseur:
MICROSOLV TECH CORP
Description:
These useful HPLC columns have a silica hydride surface similar to other TYPE-C™ phases but the uniqueness of Diamond Hydride™ is that they have a very small amount of carbon on the surface that adjusts the hydrophobicity to a small but important level. This is an excellent choice for small, polar compounds by LCMS or HPLC.
Fournisseur:
TUTTNAUER
Description:
Tuttnauer's ML laboratory line of semi-automatic, electro-mechanically controlled, vertical steam sterilizers provide safe, economical and effective sterilization. The semi-automatic laboratory autoclave series is an affordable sterilizer for laboratories that do not want to compromise on quality, safety and reliability and need to sterilize loads with low sensitivity. The semi-automatic series is available in vertical or benchtop models and in chamber sizes ranging from 23 to 160 litres. The ML models have a semi-automatic control panel, ML models have a manual control panel. The chamber is constructed of long lasting 316L grade stainless steel with superior corrosion resistance. The generator is made from stainless steel.
Sterilisation applications: Lliquids such as nutrient media and buffer solutions, solid items such as pipettes, tubes and filters, glassware and plastic articles.
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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