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Numéro de catalogue: (BOSSBS-12006R-A647)

Fournisseur:  Bioss
Description:   Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilion 1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem, whereas the four epsilon subunits display limited distribution.
UOM:  1 * 100 µl
Fournisseur:  Biotium
Description:   This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Fournisseur:  Biotium
Description:   This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Numéro de catalogue: (BOSSBS-5908R-A647)

Fournisseur:  Bioss
Description:   Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7.
UOM:  1 * 100 µl
Fournisseur:  Tonbo Biosciences
Description:   The GARP5 antibody reacts with human GARP, also known as LRRC32 or Garpin, an 80 kDa transmembrane protein which acts as a receptor for the latent form of TGF-beta 1 (pro-TGF-beta), preventing its secretion. Specifically, GARP is reported to associate with the pro-domain of TGF-beta 1, known as latency-associated peptide (LAP), which must be cleaved to release the biologically active cytokine. The putative role of GARP in sequestering the TGF-beta is important for regulating its activity, as TGF-beta signaling is involved in development and function of Th17, Treg and many other immune cell types. GARP expression has been shown on platelets and at high levels on Foxp3+ Treg cells, where it is proposed to be a phenotypic identifier for activated human Treg cells.
Numéro de catalogue: (BOSSBS-4894R-CY7)

Fournisseur:  Bioss
Description:   Catalyzes the transfer of sulfate to position 6 of galactose residues of keratan. It has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal galactose residues are sulfated. It also may function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. It participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Aggrecan is the major proteoglycan of human articular cartilage. The core protein is substituted by a number of keratan sulfate and chondroitin sulfate glycosaminoglycan chains. Whereas chondroitin sulfate is widely distributed throughout the body, keratan sulfate is primarily expressed in cartilage (joints, trachea, intervertebral discs) and cornea.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-10065R-CY5)

Fournisseur:  Bioss
Description:   Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient. Netrin-4 is related to the Laminin ∫ chains, and is therefore also designated ∫-netrin. It is present in the basement membranes of the vasculature, lateral olfactory tract, kidney and ovary. In humans, the gene encoding for the netrin-4 protein is localized to chromosome 12q22-q23. High levels of netrin-4 mRNA have also been detected in many cells and tissues, including cerebral cortex, hippocampus, amygdaloid nuclei and Purkinje cells. Netrin-4 is important in neural, kidney and vascular development.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-10065R)

Fournisseur:  Bioss
Description:   Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient. Netrin-4 is related to the Laminin ∫ chains, and is therefore also designated ∫-netrin. It is present in the basement membranes of the vasculature, lateral olfactory tract, kidney and ovary. In humans, the gene encoding for the netrin-4 protein is localized to chromosome 12q22-q23. High levels of netrin-4 mRNA have also been detected in many cells and tissues, including cerebral cortex, hippocampus, amygdaloid nuclei and Purkinje cells. Netrin-4 is important in neural, kidney and vascular development.
UOM:  1 * 100 µl
Fournisseur:  VWR Collection
Description:   Bains à circulation en acier inoxydable avec un large choix de contrôleurs de température numériques avancés ou programmables avancés. Les deux sont faciles à naviguer avec de grands écrans intuitifs et de multiples options de communication, y compris USB-A et B, RS232/485, Ethernet et sonde de température externe. Le drain du réservoir est accessible en retirant le panneau avant. Tous les modèles disposent de points de coupure de sécurité haute température réglables par l’utilisateur ainsi que d’une protection contre la surchauffe. La surface DuraTop™ est froide au toucher, même en cas de fonctionnement à hautes températures.
Fournisseur:  ANSELL HEALTH CARE
Description:   Ce gant tricoté en Spandex/nylon/Dyneema® avec revêtement fin en PU au niveau de la paume assure un haut niveau de dextérité et de sensibilité tactile pour les applications avec risques de coupures.
Numéro de catalogue: (ENZOALX803080C100)

Fournisseur:  ENZO LIFE SCIENCES
Description:   Autophagy is an alternative process of proteasomal degradation for some long-lived proteins or organelles. Alterations in the autophagic-lysosomal compartment have been linked to neuronal death in many neurodegenerative disorders as well as in transmissible neuronal pathologies (prion diseases). Genetic studies in yeast have shown that Autophagy-defective Gene-8 (Atg-8) represents a specific marker for autophagy. Among the four families of mammalian Atg8-related proteins only LC3 (Microtubule-associated Protein1 Light Chain 3) is expressed at sufficient high levels and efficiently recruited to autophagic vesicles in cells and tissues. During autophagy the cytoplasmic form, LC3-I is processed and recruited to autophagosomes, where LC3-II is generated by site specific proteolysis near to the C-terminus. Autophagic vacuoles have been also reported frequently in cardiomyopathies or muscle cells exposed to different experimental settings.
UOM:  1 * 1 EA
New Product
Fournisseur:  Liebherr
Description:   High-volume freezers with forced air cooling. White steel exterior and stainless-steel interior. The intuitive user interfaces provide useful extended multi-functionality, e.g. a maintenance timer, and the LED interior lighting ensures good visibility of the contents of these large appliances. Advanced connectivity options to suit varying requirements for simplified data storage, temperature control and alarm signals.
New Product
Fournisseur:  VWR Collection
Description:   Ces objectifs sont conçus pour être utilisés avec des microscopes inversés.
Fournisseur:  VWR Collection
Description:   Ces thermomètres sont faciles à lire rapidement et avec précision grâce à la numérotation noire à contraste élevé sur fond jaune. Idéal pour une utilisation dans les laboratoires chimiques/pétrochimiques, les universités, les institutions scientifiques, la transformation des aliments et des boissons, les industries pharmaceutiques et médicales, les laiteries, les brasseries et les distilleries.
Fournisseur:  VWR Collection
Description:   Les pantalons sous-vêtements Quantus® sont fabriqués à partir de microfibre de polyester respirant de grande qualité avec du carbone. Le tissu a été spécialement conçu pour une utilisation en tant que sous-vêtements en association avec une combinaison ou une blouse pour salles propres. Il peut être utilisé comme préfiltre pour permettre au tissu à pores ouverts d'être utilisé dans une salle propre de classe supérieure.
Numéro de catalogue: (KIMB11329)

Fournisseur:  KIMBERLY CLARK
Description:   This touchless cassette dispenser provides Kleenex® luxury foam soap or sanitiser. The skin care innovation in this electronic system represents high hygienic operation. The capacity cassette system requires less frequent refilling.
UOM:  1 * 1 ST
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