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cell+culture+flasks
Numéro de catalogue:
(ENZOADI905306100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Members of the TNF superfamily regulate immune responses and induce apoptosis. Two members of this family were identified and designated BAFF and April, respectively. Three receptors for BAFF were identified; these include: BCMA (B-cell maturation protein), TACI, and BAFF-R. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B-Cell development and survival, activate NF-κB and c-jun N-terminal kinase, and are involved in B-Cell associated autoimmune diseases.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(BOSSBS-5807R-CY5)
Fournisseur:
Bioss
Description:
ELMO1 is involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. ELMO1 acts in association with DOCK1 and CRK and was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. It is belived to enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5807R-CY7)
Fournisseur:
Bioss
Description:
ELMO1 is involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. ELMO1 acts in association with DOCK1 and CRK and was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. It is belived to enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4838R-A555)
Fournisseur:
Bioss
Description:
HE4 is a broad range protease inhibitor. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4838R-A350)
Fournisseur:
Bioss
Description:
HE4 is a broad range protease inhibitor. It is expressed in a number of normal tissues, including male reproductive system, regions of the respiratory tract and nasopharynx. It is highly expressed in a number of tumors cells lines, such ovarian, colon, breast, lung and renal cells lines.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9246R-A680)
Fournisseur:
Bioss
Description:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9636R-CY5.5)
Fournisseur:
Bioss
Description:
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(CAYM10010303-96)
Fournisseur:
Cayman Chemical
Description:
Triglyceride Colorimetric Assay Kit is a simple, reproducible and sensitive tool for assaying triglycerides in plasma, serum, cell lysates and tissue homogenate samples.
UOM:
1 * 1 KIT
Fournisseur:
Biotium
Description:
Recognizes a protein of 70 kDa, which is identified as CD86 (HLDA V; WS Code BP BP072. HLDA V; WS Code A A109. HLDA VI; WS Code BP 95. HLDA VI; WS Code B CD86.9). CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease.
Numéro de catalogue:
(BOSSBS-4004R-A350)
Fournisseur:
Bioss
Description:
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4004R-A647)
Fournisseur:
Bioss
Description:
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8187R-A350)
Fournisseur:
Bioss
Description:
The CUB and sushi domain-containing proteins, CSMD1-3, are membrane proteins that are involved in cell-cell adhesion and are weakly expressed in most tissues, with higher levels of expression observed in the cerebellum and hippocampus. CSMD1 is part of the complement system that defends against pathogens through either the classical pathway or the alternative pathway. Located primarily in nerve growth cones, CSMD1 blocks the classical pathway of the immune system and is thought to be involved in tumor suppression, as defects in the gene encoding CSMD1 are associated with squamous cell carcinomas. CSMD2 and CSMD3 are located primarily in the brain and are implicated in some forms of head and neck cancer. Additionally, the CSMD3 gene is a candidate for induction of epileptic seizures.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1970R-CY7)
Fournisseur:
Bioss
Description:
Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1970R-FITC)
Fournisseur:
Bioss
Description:
Lysosome associated membrane protein (LAMP1), also known as lgp120 or lgpA, is a type 1 integral membrane protein that is transported from trans Golgi networks to endosomes and then lysosomes. Upon cell activation, LAMP1 transfer to the plasma membrane is dependent on a carboxyl terminal tyrosine based motif (YXXI). Perturbation in the spacing between the tyrosine based motif relative to the membrane abolishes lysosome localization of LAMP1. This mutant protein then cycles between the plasma membrane and the endosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4015R-CY5)
Fournisseur:
Bioss
Description:
IRGM belongs to a family of interferon-gamma inducible GTPases, belonging to the GTPase superfamily, and are selectively induced by IFN-gamma or bacterial lipopolysaccharide (LPS) stimulation. IRGM is primarily expressed in all cells derived from B-cell lineages, and is highly expressed in macrophages following IFN-gamma stimulation. IRGM has been shown to be required for host defences against a broad range of intracellular pathogens. Specifically, IRGM deficient mice show defects with intracellular microbial killing, phagosome maturation and autophagy. More recently IRGM has been shown to inhibit baseline hematopoietic proliferation and is required for a normal hematopoietic stem cell response to chemical and infectious stimuli.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6335R-FITC)
Fournisseur:
Bioss
Description:
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
UOM:
1 * 100 µl
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