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mycoplasma+detection
Numéro de catalogue:
(BOSSBS-13247R-HRP)
Fournisseur:
Bioss
Description:
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein Alpha, Beta and Gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their Alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G Alpha subunits have been identified; these include G Alpha s, G Alpha i, G Alpha q and G Alpha 12/13. The two members of the fourth class of G Alpha subunit proteins, G Alpha 12 and G Alpha 13, are insensitive to ADP-ribosylation by pertussis toxin, share 67% identity with each other and less than 45% identity with other G Alpha subunits and are widely expressed in a broad range of tissues.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13248R-FITC)
Fournisseur:
Bioss
Description:
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1). Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenylyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, Beta and Gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2-5). Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G alpha subunits have been identified; these include Gs, Gi, Gq and Ga 12/13 (3,4). The Gi class comprises all the known a subunits that are susceptible to pertussis toxin modifications, including Ga i-1, Ga i-2, Ga i-3, Ga o, Ga t1, Ga t2, Ga z and Ga gust (4). Of these, the three Ga i subtypes function to open atrial potassium channels (6). Ga 16 is a member of the Gq subfamily and is expressed specifically in hematopoietic cells (7).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11059R-HRP)
Fournisseur:
Bioss
Description:
Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins as the cells are repelled, rather than attracted, by the netrin gradient. Neogenin serves as the primary guidance receptor for netrin-3. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin-3 proteins are associated with the axon fibers projecting from motor neurons and from neurons within sympathetic and sensory ganglia, suggesting that netrin-3 may be involved in pathfinding and fasciculation of axon projection. Neogenin serves as the primary guidance receptor for netrin-3. During peripheral nerve development, high netrin-3 expression has been detected in mesenchymal cells, sensory ganglia and muscles. In humans, the gene encoding for the netrin-3 protein is localized to chromosome 16p13.3.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9474R-CY5)
Fournisseur:
Bioss
Description:
Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9474R)
Fournisseur:
Bioss
Description:
Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins, Fos and Jun, on DNA to regulate cytokine expression in T cells. NFAT proteins are widely expressed and alternatively modified to generate splice variants, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn). NFAT1, NFAT2, and NFAT4 are predominantly expressed in immune cells, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues. In addition to activating cytokine gene transcription, NFAT2 is also implicated in cardiac valve development, and NFAT3 is involved in cardiac hypertrophy. NFAT5 is detected in both immune and nonimmune cells and, like other NFAT proteins, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA. NFAT proteins are activated by increases in intracellular calcium, which leads to the calmodulin-dependent phosphatase, calcineurin, dephosphorylating NFAT proteins. This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus.
UOM:
1 * 100 µl
Fournisseur:
Dräger
Description:
Long-term measurements with diffusion tubes provide integrated measurements that represent the average concentration during the sampling period.
Numéro de catalogue:
(BOSSBS-9874R-A680)
Fournisseur:
Bioss
Description:
Two families of mammalian lectin-like adhesion molecules bind glycoconjugate ligands in a sialic acid-dependent manner: the selectins and the sialoadhesins. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members recognizing sialylated ligands. The common sialic acids of mammalian cells are N-acetyl-neuraminic acid (Neu5Ac) and N-glycolyl-neuraminic acid (Neu5Gc). Siglec-1 mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells. Siglec-7, highly expressed in monocytes and resident blood cells, but not in parenchymatous cells, mediates inhibition of natural killer cell cytotoxicity. Siglec-9 is closely homologous to Siglec-7; the gene encoding it maps to chromosome 19q13.41 in humans. It is highly expressed in peripheral blood leukocytes (but not eosinophils), liver, bone marrow, placenta and spleen. Siglec-8, a type I membrane protein, is selectively expressed on human eosinophils, basophils and mast cells, where it regulates their function and survival.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11902R-A647)
Fournisseur:
Bioss
Description:
The nm23 gene (Metastasis inhibition factor nm23), a potential suppressor of metastasis, is expressed at a much lower level in highly metastatic cells than in cells with lower metastatic potential. Based on sequence analysis, nm23, also designated nucleoside diphosphate kinase A (NDK A) or Tumor metastatic process-associated protein, appears to be highly related to nucleotide diphosphate kinases (NDP). NDP kinases A and B are identical to two isotypes of human nm23 homologs, nm23-H1 and nm23-H2, respectively. nm23-H2 is also identical in sequence to PuF, a transcription factor that binds to nuclease-hypersensitive elements at positions 142 to 115 of the human c-Myc promoter. nm23-H3 and nm23-H4 are important for the synthesis of nucleoside triphosphates and may play a role in apoptosis induction and hematopoiesis. nm23-H4 localizes to the mitochondrial intermembrane space and is widely expressed, with higher levels detected in prostate, heart, liver, small intestine, and skeletal muscle tissues. Low amounts of nm23-H4 are observed in the brain and in blood leukocytes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11902R-A488)
Fournisseur:
Bioss
Description:
The nm23 gene (Metastasis inhibition factor nm23), a potential suppressor of metastasis, is expressed at a much lower level in highly metastatic cells than in cells with lower metastatic potential. Based on sequence analysis, nm23, also designated nucleoside diphosphate kinase A (NDK A) or Tumor metastatic process-associated protein, appears to be highly related to nucleotide diphosphate kinases (NDP). NDP kinases A and B are identical to two isotypes of human nm23 homologs, nm23-H1 and nm23-H2, respectively. nm23-H2 is also identical in sequence to PuF, a transcription factor that binds to nuclease-hypersensitive elements at positions 142 to 115 of the human c-Myc promoter. nm23-H3 and nm23-H4 are important for the synthesis of nucleoside triphosphates and may play a role in apoptosis induction and hematopoiesis. nm23-H4 localizes to the mitochondrial intermembrane space and is widely expressed, with higher levels detected in prostate, heart, liver, small intestine, and skeletal muscle tissues. Low amounts of nm23-H4 are observed in the brain and in blood leukocytes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11902R-A750)
Fournisseur:
Bioss
Description:
The nm23 gene (Metastasis inhibition factor nm23), a potential suppressor of metastasis, is expressed at a much lower level in highly metastatic cells than in cells with lower metastatic potential. Based on sequence analysis, nm23, also designated nucleoside diphosphate kinase A (NDK A) or tumour metastatic process-associated protein, appears to be highly related to nucleotide diphosphate kinases (NDP). NDP kinases A and B are identical to two isotypes of human nm23 homologs, nm23-H1 and nm23-H2, respectively. nm23-H2 is also identical in sequence to PuF, a transcription factor that binds to nuclease-hypersensitive elements at positions 142 to 115 of the human c-Myc promoter. nm23-H3 and nm23-H4 are important for the synthesis of nucleoside triphosphates and may play a role in apoptosis induction and hematopoiesis. nm23-H4 localizes to the mitochondrial intermembrane space and is widely expressed, with higher levels detected in prostate, heart, liver, small intestine, and skeletal muscle tissues. Low amounts of nm23-H4 are observed in the brain and in blood leukocytes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11902R-FITC)
Fournisseur:
Bioss
Description:
The nm23 gene (Metastasis inhibition factor nm23), a potential suppressor of metastasis, is expressed at a much lower level in highly metastatic cells than in cells with lower metastatic potential. Based on sequence analysis, nm23, also designated nucleoside diphosphate kinase A (NDK A) or Tumor metastatic process-associated protein, appears to be highly related to nucleotide diphosphate kinases (NDP). NDP kinases A and B are identical to two isotypes of human nm23 homologs, nm23-H1 and nm23-H2, respectively. nm23-H2 is also identical in sequence to PuF, a transcription factor that binds to nuclease-hypersensitive elements at positions 142 to 115 of the human c-Myc promoter. nm23-H3 and nm23-H4 are important for the synthesis of nucleoside triphosphates and may play a role in apoptosis induction and hematopoiesis. nm23-H4 localizes to the mitochondrial intermembrane space and is widely expressed, with higher levels detected in prostate, heart, liver, small intestine, and skeletal muscle tissues. Low amounts of nm23-H4 are observed in the brain and in blood leukocytes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11902R-HRP)
Fournisseur:
Bioss
Description:
The nm23 gene (Metastasis inhibition factor nm23), a potential suppressor of metastasis, is expressed at a much lower level in highly metastatic cells than in cells with lower metastatic potential. Based on sequence analysis, nm23, also designated nucleoside diphosphate kinase A (NDK A) or Tumor metastatic process-associated protein, appears to be highly related to nucleotide diphosphate kinases (NDP). NDP kinases A and B are identical to two isotypes of human nm23 homologs, nm23-H1 and nm23-H2, respectively. nm23-H2 is also identical in sequence to PuF, a transcription factor that binds to nuclease-hypersensitive elements at positions 142 to 115 of the human c-Myc promoter. nm23-H3 and nm23-H4 are important for the synthesis of nucleoside triphosphates and may play a role in apoptosis induction and hematopoiesis. nm23-H4 localizes to the mitochondrial intermembrane space and is widely expressed, with higher levels detected in prostate, heart, liver, small intestine, and skeletal muscle tissues. Low amounts of nm23-H4 are observed in the brain and in blood leukocytes.
UOM:
1 * 100 µl
Fournisseur:
Biotium
Description:
Recognizes a protein of 33-37 kDa, identified as CD20 (Workshop V; Code CD20.12). B9E9 recognizes extracellular domain of CD20. The epitope is similar to or identical to that recognized by other CD20 antibodies including Leu-16 and B1. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood, B cell localization in tissues and B lymphocyte purification by immunosorbent methods. CD20 is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. Protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as a calcium channel involved in B-cell activation and cell cycle progression.
Fournisseur:
Biotium
Description:
This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Fournisseur:
Biotium
Description:
This MAb stains the cytoplasm of macrophages and histiocytes in hematopoietic organs, Kupffer's cells of the liver and Langerhan's cells of the skin. It also stains the mantle zone B-lymphocytes of the lymph node and spleen, spermatogonia, and chief cells of the stomach. S100A9 is expressed by macrophages in acutely inflamed tissues and in chronic inflammation. It is detected in peripheral blood leukocytes, in neutrophils and granulocytes. It is present at sites of vascular inflammation. S100A9 is also expressed in epithelial cells constitutively or induced during dermatoses. S100A9 is a Calcium-binding protein. It has antimicrobial activity towards bacteria and fungi. It is important for resistance to invasion by pathogenic bacteria. It up-regulates transcription of genes that are under the control of NF-kappa-B. S100A9 plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS). It promotes tubulin polymerization when unphosphorylated. It also promotes phagocyte migration and infiltration of granulocytes at sites of wounding. It plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1.
Numéro de catalogue:
(BOSSBS-13247R-A680)
Fournisseur:
Bioss
Description:
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein Alpha, Beta and Gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their Alpha subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G Alpha subunits have been identified; these include G Alpha s, G Alpha i, G Alpha q and G Alpha 12/13. The two members of the fourth class of G Alpha subunit proteins, G Alpha 12 and G Alpha 13, are insensitive to ADP-ribosylation by pertussis toxin, share 67% identity with each other and less than 45% identity with other G Alpha subunits and are widely expressed in a broad range of tissues.
UOM:
1 * 100 µl
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