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Anticorps
Numéro de catalogue:
(BOSSBS-3347R-A350)
Fournisseur:
Bioss
Description:
Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) induces proliferation, migration, and fenestration in capillary endothelial cells derived from endocrine glands. EG-VEGF possesses an HIF-1 binding site; its expression is induced by hypoxia and restricted to the steroidogenic glands (ovary, testis, adrenal and placenta). Expression of EG-VEGF is often complementary to the expression of VEGF, suggesting that these molecules function in a coordinated manner. EG-VEGF is an example of a class of highly specific mitogens that act to regulate proliferation and differentiation of the vascular endothelium in a tissue-specific manner. It is expressed primarily in one type of tissue and acts selectively on one type of endothelium. EG-VEGF, possibly through binding to a G protein-coupled receptor, results in the activation of MAPK p44/42 and phosphatidylinositol 3-kinase signaling pathways, leading to proliferation, migration and survival of responsive endothelial cells .
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11097R-A750)
Fournisseur:
Bioss
Description:
NIPAL3 is a 406 amino acid multi-pass membrane protein that belongs to the NIPA family and exists as three alternatively spliced isoforms. The gene that encodes NPAL3 consists of approximately 57229 bases and maps to human chromosome 1p36. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15048R-A350)
Fournisseur:
Bioss
Description:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf189 gene product has been provisionally designated C1orf189 pending further characterization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15048R-HRP)
Fournisseur:
Bioss
Description:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf189 gene product has been provisionally designated C1orf189 pending further characterization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15389R-A680)
Fournisseur:
Bioss
Description:
GPR180 is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1538R-HRP)
Fournisseur:
Bioss
Description:
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15389R-HRP)
Fournisseur:
Bioss
Description:
GPR180 is a member of the G protein-coupled receptor superfamily. This protein is produced predominantly in vascular smooth muscle cells and may play an important role in the regulation of vascular remodeling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7073R-CY5)
Fournisseur:
Bioss
Description:
NME5 does not seem to have NDK kinase activity but confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. It may play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. NME5 is specifically expressed in testis germinal cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11174R-HRP)
Fournisseur:
Bioss
Description:
KY peptidase (Kyphoscoliosis peptidase) is a 561 amino acid cytoskeleton protease that interacts with several sarcomeric cytoskeletal proteins, including Filamin 2. KY peptidase probably plays a role in the maturation, function and stabilization of the neuromuscular junction. KY-null mouse mutants exhibit distinct irregular subceullular Filamin 2 localization, suggesting that KY peptidase deficiency may be the cause of several types of limb-girdle muscular dystrophies.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11175R-CY7)
Fournisseur:
Bioss
Description:
Lubricin, also designated proteoglycan-4 or megakaryocyte stimulating factor, is important for boundary lubrication within articulating joints. It is a disulfide-linked homodimer (between Cysteine 1146 and Cysteine 1403) that is essential for protein cleavage. Lubricin inhibits synovial cell adhesion to the cartilage surface, but also prevents the deposition of proteins from synovial fluid onto cartilage. Lubricin is highly expressed in cartilage, liver and synovial tissue. Defects in the gene encoding for lubricin can cause Jakobs syndrome, also designated camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). CACP is an autosomal recessive disorder characterized by joint failure associated with noninflammatory synoviocyte hyperplasia and subinitimal fibrosis of the synovial capsule. Lubricin undergoes different levels of glycosylation and may be detected at varying molecular weights.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7770R-A555)
Fournisseur:
Bioss
Description:
The SEPT10 gene encodes a member of the septin family of cytoskeletal proteins which have GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternate splicing results in two transcript variants encoding different isoforms.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7720R-A680)
Fournisseur:
Bioss
Description:
Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3950R-CY7)
Fournisseur:
Bioss
Description:
The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7720R-A750)
Fournisseur:
Bioss
Description:
Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13187R-CY5)
Fournisseur:
Bioss
Description:
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13187R-A488)
Fournisseur:
Bioss
Description:
In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.
UOM:
1 * 100 µl
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