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Protéines et Peptides
Numéro de catalogue:
(PRSI96-611)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-610)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI96-630)
Fournisseur:
ProSci Inc.
Description:
Human recombinant PLAU (from HEK293 cells)
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-RP3143)
Fournisseur:
ProSci Inc.
Description:
Methionine adenosyltransferase (EC 2.5.1.6) catalyzes the biosynthesis of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the major methyl donor for many of the transmethylation reactions in the body. The MAT2A promoter is highly GC rich, especially in the first 300 bp. The promoter contains several potential SP1-, v-myb-, and GATA-binding sites, as well as potential binding sites for C/EBP, HSF2, c-myb, and STATx. It can efficiently drive expression from a reporter gene in both Jurkat and 293 cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3253)
Fournisseur:
ProSci Inc.
Description:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein binds to fanconi anemia complementation group A protein, but its function is unknown. This gene results in two transcript variants encoding the same protein.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7067P)
Fournisseur:
ProSci Inc.
Description:
CITED2 peptide is used for blocking the activity of CITED2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5485P)
Fournisseur:
ProSci Inc.
Description:
PLEKHM2 peptide is used for blocking the activity of PLEKHM2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5487P)
Fournisseur:
ProSci Inc.
Description:
PLEKHM3 peptide is used for blocking the activity of PLEKHM3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5391P)
Fournisseur:
ProSci Inc.
Description:
AGTR1 peptide is used for blocking the activity of AGTR1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4051P)
Fournisseur:
ProSci Inc.
Description:
TIGAR peptide is used for blocking the activity of TIGAR antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI40-514)
Fournisseur:
ProSci Inc.
Description:
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 119 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3457P)
Fournisseur:
ProSci Inc.
Description:
Caspase-5 peptide is used for blocking the activity of Caspase-5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3491P)
Fournisseur:
ProSci Inc.
Description:
Raptor peptide is used for blocking the activity of the Raptor antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7111P)
Fournisseur:
ProSci Inc.
Description:
HEPACAM2 Peptide is used for blocking the activity of HEPACAM2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5441P)
Fournisseur:
ProSci Inc.
Description:
GOLPH2 peptide is used for blocking the activity of GOLPH2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4055P)
Fournisseur:
ProSci Inc.
Description:
VISA peptide is used for blocking the activity of VISA antibody.
UOM:
1 * 50 µG
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