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Protéines et Peptides
Numéro de catalogue:
(STMC100-1324)
Fournisseur:
STEMCELL Technologies
Description:
Use autotaxin (ENPP2) to catalyse the production of lysophosphatidic acid (LPA), a potent mitogen that can evoke growth factor-like responses (Moolenaar and Corven), from lysophospholipids in extracellular fluids. Autotaxin is a secreted glycoprotein that belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP) family, containing two N-terminal somatomedin B (SMB)-like domains, a central phosphodiesterase (PDE) domain with an active catalytic site, and a C-terminal nuclease-like (NUC) domain (Nishimasu <i>et al.</i>). Dysregulation of autotaxin and LPA receptors is implicated in cancer (Tigyi <i>et al.</i>), fibrosis (Ninou <i>et al.</i>), neurological disorders (Roy <i>et al.</i>), and other inflammation-associated conditions. Both Autotaxin and LPA are overexpressed in many cancers and can promote cell proliferation, migration, and resistance to apoptotic death (Tigyi <i>et al.</i>). Autotaxin was also found to catalyse the production of cyclic phosphatidic acid (CPA), an analog of LPA, which has anti-mitogenic and inhibitory effects on tumor cell invasion and metastasis (Fujiwara). This protein contains a His-residue tag at the amino end of the polypeptide chain. For consistency and reproducibility across your applications, Autotaxin from STEMCELL comes lyophilised with ≥85% purity, and endotoxin levels are verified to be ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
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Numéro de catalogue:
(STMC100-1394)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with HPV16 (E7) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HPV16 (E7) Peptide pool is a lyophilised mixture of 22 peptides from protein E7 of human papillomavirus type 16 (HPV16) consisting of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 98 on protein E7. E7 is an oncoprotein that binds and mediates degradation of the retinoblastoma tumor suppressor protein pRB (Gonzalez <i>et al.</i>). E7 together with E6 demonstrated the ability to immortalize human keratinocytes in vitro, which likely has significance for HPVs oncogenic potential (Hawley-Nelson <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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Numéro de catalogue:
(STMC100-1385)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with HIV-1 (B Gag) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HIV-1 (B Gag) Peptide Pool is a lyophilised mixture of 123 peptides from the gag polyprotein of human immunodeficiency virus 1 (HIV-1). The pool consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 500 on gag polyprotein. The HIV-1 gag polyprotein is a key mediator of viral particle assembly (Campbell and Rein; Dong <i>et al.</i>), and together with the endosomal sorting complexes required for transport (ESCRT), results in budding during virion release (Carlson <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Persephin is a neurotrophic factor that belongs to the glial cell line-derived neurotrophic factor (GDNF) family. Persephin shares a large degree of structural similarity to GDNF, artemin, and neurturin, and has overall neuroprotective activity. Persephin signals through GRFα4 (glycosylphosphatidylinositol (GPI)-linked GDNF receptor family member) which signals through the receptor tyrosine kinase RET. Unlike GDNF and neurturin, persephin only promotes the growth and survival of central dopaminergic and motor neurons, but not peripheral neurons (Milbrandt <i>et al.</i>). In vitro, persephin only promotes survival of neurons that co-express GPI-linked GRFα4 and RET (Enokido <i>et al.</i>; Lindahl <i>et al.</i>). Mice lacking persephin showed increased cell death after cerebral ischemia, however administration of persephin before ischemia dramatically reduced neuronal cell death (Tomac <i>et al.</i>).
Numéro de catalogue:
(STMC100-1384)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with HIV (HLA Class I Control) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. HIV Peptide pool is a lyophilised mixture of 22 peptides from human immunodeficiency virus (HIV), and consists of defined HLA class I-restricted T cell epitopes. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1323)
Fournisseur:
STEMCELL Technologies
Description:
Mediate calcium phosphate clearance and prevent ectopic calcification with fetuin A, a plasma glycoprotein that forms soluble complexes with calcium and phosphate (Heiss <i>et al.</i>; Price and Lin). Belonging to the cystatin superfamily of cysteine protease inhibitors (Brown and Dziegielewska), fetuin A has also been shown to play a role in lipid transport, acting as a carrier (Kumbla <i>et al.</i>). In cell-based assays, it has been suggested that fetuin A protects against lethal systemic infection through the inhibition of high mobility group box 1 (HMGB1) protein accumulation and release (Li <i>et al.</i>). Fetuin A acts as a natural antagonist against specific TGF-β and BMP signaling proteins, blocking osteogenic differentiation of rat bone marrow cells (Demetriou <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, fetuin A from STEMCELL comes lyophilised with ≥94% purity, and endotoxin levels are verified to be ≤1.0 EU/μg protein.
UOM:
1 * 1 EA
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1381)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with SARS-CoV-2 (Spike Protein) Delta/B.1.617.2 WT reference peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This peptide pool is a lyophilised mixture of 27 peptides from the spike glycoprotein of the wild-type SARS-CoV-2 virus. Consisting of the wild-type peptides that correspond to the mutated portions of the spike protein found in the SARS-CoV-2 Delta variant (B.1.617.2), this pool is recommended to be used as a reference for the SARS-CoV-2 (Spike Protein) Delta/B.1.617.2 Mutation Peptide Pool. Through interactions with the angiotensin-converting enzyme 2 (ACE2) receptor, the spike protein enables the virus to attach to the cell membrane, and plays a critical role in viral entry (Hoffmann <i>et al.</i>; Walls <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
ACROBIOSYSTEMS
Description:
FITC-Labeled Human Siglec-3 / CD33 Protein, His Tag.
Fournisseur:
ACROBIOSYSTEMS
Description:
Human recombinant FOLR1 (from HEK293 cells), FITC (Fluorescein Isothiocyanate)
Fournisseur:
Biorbyt
Description:
Human recombinant Cathepsin B (from HEK293 cells)
Fournisseur:
ACROBIOSYSTEMS
Description:
Human recombinant Fc gamma RIIA/ CD32a (from HEK293 cells)
Fournisseur:
Roth Carl
Description:
Gelatin
Fournisseur:
Biorbyt
Description:
Human Recombinant CD172A (from HEK293 cells)
Fournisseur:
Biorbyt
Description:
Yeast recombinant yeast TRX (from <i>Escherichia coli</i>)
Fournisseur:
Biorbyt
Description:
Human recombinant WIF1 (from HEK293 cells)
Fournisseur:
STEMCELL Technologies
Description:
Granulocyte-macrophage colony-stimulating factor (GM-CSF) promotes the proliferation and differentiation of hematopoietic progenitor cells and the generation of neutrophils, eosinophils, and macrophages. In synergy with other cytokines such as stem cell factor, IL-3, erythropoietin, and thrombopoietin, it also stimulates erythroid and megakaryocyte progenitor cells (Barreda <i>et al.</i>). GM-CSF is produced by multiple cell types, including stromal cells, Paneth cells, macrophages, dendritic cells (DCs), endothelial cells, smooth muscle cells, fibroblasts, chondrocytes, and Th1 and Th17 T cells (Francisco-Cruz <i>et al.</i>). The receptor for GM-CSF (GM-CSFR) is composed of two subunits: the cytokine-specific α subunit (GMRα; CD116) and the common subunit βc (CD131) shared with IL-3 and IL-5 receptors (Broughton <i>et al.</i>). GM-CSFR is expressed on hematopoietic cells, including progenitor cells and immune cells, as well as non-hematopoietic cells. Recombinant human GM-CSF (rhGM-CSF) promotes the production of myeloid cells of the granulocytic (neutrophils, eosinophils and basophils) and monocytic lineages in vivo. It has been tested for mobilization of hematopoietic progenitor cells and for treating chemotherapy-induced neutropenia in patients. GM-CSF is able to stimulate the development of DCs that ingest, process, and present antigens to the immune system (Francisco-Cruz <i>et al.</i>).
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