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Bioss
Numéro de catalogue:
(BOSSBS-11963R-CY7)
Fournisseur:
Bioss
Description:
There are three SorCS genes that have diverse, partially overlapping functions in the central nervous system. In the developing and mature central nervous system, SorCS1, SorCS2 and SorCS3 genes are expressed in a combinatorial, non-overlapping pattern. SorCS proteins show homology to the mosaic receptor SorLA and the neurotensin receptor sortilin, based on a common VPS10 domain, which is the hallmark of the SorCS receptor family. SorCS2 (sortilin-related VPS10 domain containing receptor 2) is a 1,150 amino acid single-pass type I membrane protein that is highly expressed in brain and kidney. Containing six BNR repeats and a single PKD domain, SorCS2 is encoded by a gene that maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4965R-HRP)
Fournisseur:
Bioss
Description:
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8482R-A350)
Fournisseur:
Bioss
Description:
Plays a major role in tight junction-specific obliteration of the intercellular space.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8481R-A680)
Fournisseur:
Bioss
Description:
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesised MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4965R-FITC)
Fournisseur:
Bioss
Description:
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8482R-CY5)
Fournisseur:
Bioss
Description:
Plays a major role in tight junction-specific obliteration of the intercellular space.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4966R-A488)
Fournisseur:
Bioss
Description:
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8482R-HRP)
Fournisseur:
Bioss
Description:
Plays a major role in tight junction-specific obliteration of the intercellular space.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8482R-CY5.5)
Fournisseur:
Bioss
Description:
Plays a major role in tight junction-specific obliteration of the intercellular space.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7984R-A488)
Fournisseur:
Bioss
Description:
Carbonic anhydrases are a large family of zincmetalloenzymes that catalyze the reversible hydration of carbondioxide. They participate in a variety of biological processes,including respiration, calcification, acid-base balance, boneresorption, and the formation of aqueous humor, cerebrospinalfluid, saliva, and gastric acid. They show extensive diversity intissue distribution and in their subcellular localization. Thecytosolic protein encoded by this gene is predominantly expressedin the salivary glands. Alternative splicing in the coding regionresults in multiple transcript variants encoding differentisoforms. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11538R-A680)
Fournisseur:
Bioss
Description:
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin-dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. CDKL5 (cyclin-dependent kinase-like 5) is a 1030 amino acid protein that belongs to the CMGC Ser/Thr protein kinase family. Expressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis, CDKL5 is thought to play a role in cell cycle regulation. Defects in CDKL5 are a cause of several disorders, such as X-linked infantile spasm syndrome and Rett syndrome.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7983R-FITC)
Fournisseur:
Bioss
Description:
The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7983R-A680)
Fournisseur:
Bioss
Description:
The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1158R-CY5)
Fournisseur:
Bioss
Description:
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 8% of all plasma zinc.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4109R-CY3)
Fournisseur:
Bioss
Description:
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. May play a role in the control of cell migration through the TOR signaling cascade.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1153R-A350)
Fournisseur:
Bioss
Description:
Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c.
UOM:
1 * 100 µl
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