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Bioss
Numéro de catalogue:
(BOSSBS-3851R-CY5)
Fournisseur:
Bioss
Description:
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7632R-A350)
Fournisseur:
Bioss
Description:
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3194R-A488)
Fournisseur:
Bioss
Description:
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7089R-FITC)
Fournisseur:
Bioss
Description:
Activates NF-kappa-B via BCL10.Tissue specificity; Highly expressed in spleen. Also detected in liver, placenta, lung, peripheral blood leukocytes and in brain.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7088R-HRP)
Fournisseur:
Bioss
Description:
Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15270R-A488)
Fournisseur:
Bioss
Description:
Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterised by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. The C7orf45 gene product has been provisionally designated C7orf45 pending further characterisation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11181R-FITC)
Fournisseur:
Bioss
Description:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4065R-A680)
Fournisseur:
Bioss
Description:
Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11620R-A750)
Fournisseur:
Bioss
Description:
The regulators of G protein Signalling (RGS) proteins inhibit heterotrimeric G protein Signalling. RGS proteins work by functioning as GTPase-activators (which increase the GTPase activity of G protein a-subunits) thereby driving G proteins into their inactive GDP-bound form. RGS21 (regulator of G-protein Signalling 21) is a 152 amino acid protein that is ubiquitously expressed and contains one RGS domain. The gene encoding RGS21 maps to human chromosome 1q31.2 and mouse chromosome 1 F. Human chromosome 1 spans 260 million base pairs, contains over 3000 genes, comprises nearly 8% of the human genome and houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4066R-CY7)
Fournisseur:
Bioss
Description:
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11667R-A750)
Fournisseur:
Bioss
Description:
PET112L is the human homolog of the S. cerevisiae COX assembly protein pet112, a protein that is believed to play an important role in the translation of mitochondrial genes. PET112L, also known as HSPC199 or Glu-ADT subunit B (glutamyl-tRNA(Gln) amidotransferase subunit B), is a 557 amino acid protein belonging to the gatB/gatE family of proteins (GatB subfamily) and is believed to play a role in energy metabolism. Localizing to mitochondria, PET112L is expressed in tissues such as heart and muscle, which exhibit high rates of oxidative phosphorylation. The gene encoding PET112L is overexpressed in recurrent ependymoma.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4066R-FITC)
Fournisseur:
Bioss
Description:
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6114R-A750)
Fournisseur:
Bioss
Description:
This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6115R-A750)
Fournisseur:
Bioss
Description:
TUSC3 belongs to the OST3/OST6 family of proteins and may be involved in N-glycosylation through its association with N-oligosaccharyl transferase. The TUSC3 gene is a candidate tumour supressor.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0810R-HRP)
Fournisseur:
Bioss
Description:
Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8878R-A750)
Fournisseur:
Bioss
Description:
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
UOM:
1 * 100 µl
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