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Bioss
Numéro de catalogue:
(BOSSBS-3777R-A647)
Fournisseur:
Bioss
Description:
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7876R-CY5)
Fournisseur:
Bioss
Description:
May play a role in fertility and microtubule formation through interaction with RANBP9.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1642R-A647)
Fournisseur:
Bioss
Description:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. [SUBCELLULAR LOCATION] Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6899R-A555)
Fournisseur:
Bioss
Description:
STK40 may be a negative regulator of NF-kappa-B and p53-mediated gene transcription. There are four named isoforms.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3331R-FITC)
Fournisseur:
Bioss
Description:
6 Phosphofructo 2 Kinase plays a role in the synthesis and degradation of fructose 2,6-bisphosphate. Fructose-2,6-bisphosphate acts as an allosteric regulator of 6-phosphofructo-1-kinase (PFK1), which catalyses a key step in the glycoytic pathway. Glycolytic flux is key to tumour growth, and small molecule inhibition of 6 Phosphofructo 2 Kinase suppresses both glycolytic flux and tumour growth. Several lines of evidence suggest that 6 Phosphofructo 2 Kinase is also involved in obesity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3388R-CY7)
Fournisseur:
Bioss
Description:
May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6899R-CY5.5)
Fournisseur:
Bioss
Description:
STK40 may be a negative regulator of NF-kappa-B and p53-mediated gene transcription. There are four named isoforms.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15203R-A750)
Fournisseur:
Bioss
Description:
C5orf35 is a With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. The C5orf35 gene product has been provisionally designated C5orf35 pending further characterization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11514R-A350)
Fournisseur:
Bioss
Description:
The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2 general classes of receptors, A (CCKAR)and B (CCKBR), based on their binding affinities for CCK/gastrin family peptides. Through binding to class A receptors, CCK is a major physiologic mediator of gallbladder contraction and pancreatic enzyme secretion. It appears to play a role in slowing gastric emptying, relaxation of the sphincter of Oddi, and potentiation of insulin secretion. Further, it has been implicated as a mediator of pancreatic growth and tumorigenesis. Class A receptors have also been described in the anterior pituitary, myenteric plexus, and regions of the central nervous system, where they have been implicated in the pathogenesis of feeding disorders, Parkinson disease, schizophrenia, and drug addiction.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7951R-A488)
Fournisseur:
Bioss
Description:
The function of ADCK1 is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11667R-CY5)
Fournisseur:
Bioss
Description:
PET112L is the human homolog of the S. cerevisiae COX assembly protein pet112, a protein that is believed to play an important role in the translation of mitochondrial genes. PET112L, also known as HSPC199 or Glu-ADT subunit B (glutamyl-tRNA(Gln) amidotransferase subunit B), is a 557 amino acid protein belonging to the gatB/gatE family of proteins (GatB subfamily) and is believed to play a role in energy metabolism. Localizing to mitochondria, PET112L is expressed in tissues such as heart and muscle, which exhibit high rates of oxidative phosphorylation. The gene encoding PET112L is overexpressed in recurrent ependymoma.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4064R-A488)
Fournisseur:
Bioss
Description:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11512R-A750)
Fournisseur:
Bioss
Description:
Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterised by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. Other associated clinical findings in BBS patients include diabetes, hypertension, and congenital heart defects. BBS genes map to multiple loci and encode fourteen proteins, BBS1-BBS14. Many BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS10 (Bardet-Biedl syndrome 10), also known as chromosome 12 open reading fame 58, C12orf58 or FLJ23560, is a novel 723 amino acid protein belonging to the TCP-1 chaperonin family. BBS10 localizes to the basal body of primary cilium and assists in protein folding upon ATP hydrolysis. Inhibition of BBS10 has been found to impair ciliogenesis, activate the glycogen synthase kinase 3 pathway and cause peroxisome proliferator-activated receptor nuclear accumulation. The gene encoding BBS10 contains two exons and maps to human chromosome 12q21.2.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11665R-A680)
Fournisseur:
Bioss
Description:
Clathrin-coated pits and vesicles are assembled for receptor-mediated endocytosis through interaction with clathrin associated protein complexes. Vesicle transport is mediated from the trans-Golgi network by the adapter complex AP-1 and from the plasma membrane by the AP-2 complex. The AP-1 and AP-2 adapter protein complexes consist of clathrin binding adaptin proteins and two smaller subunits known as AP50 and AP17. The Alpha- and Beta-Adaptin chains have a similar two-domain organization with C-terminal domains that vary in both sequence and length. Alpha-Adaptin splice variants A and C display variable relative expression levels and differential distribution in different tissues. AP180 (also designated AP-3 or F1-20) is a synapse-specific clathrin assembly protein. The protein CALM (clathrin assembly protein lymphoid myeloid leukaemia) is highly homologous to AP180 and may also be involved in clathrin assembly.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4064R-A647)
Fournisseur:
Bioss
Description:
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8023R-A350)
Fournisseur:
Bioss
Description:
This gene belongs to the chemokine-like factor gene superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
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