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Bioss
Numéro de catalogue:
(BOSSBS-9456R-A680)
Fournisseur:
Bioss
Description:
NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9210R-A680)
Fournisseur:
Bioss
Description:
The serine proteinase inhibitors (serpins) compose a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. The monocyte/neutrophil elastase inhibitor gene, SERPINB1, belongs to the Ov-serpin family (ovalbumin-related serpins). Human SerpinB1, also designated monocyte/neutrophil elastase inhibitor (M/NEI) or leukocyte elastase inhibitor (LEI), is a cytoplasmic protein which acts as a fast-acting stoichiometric proteinase inhibitor that regulates the activity of neutrophil elastase (NE), cathepsin-G and proteinase-3. There are four homologous genes in mouse designated SerpinB1a, SerpinB1b, SerpinB1c and the pseudogene, Serpinb1-ps1. The three protein-coding genes share significant sequence identity, however SerpinB1a (also designated EIA) has been characterised as the functional ortholog of human SerpinB1.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBSM-2028M-A750)
Fournisseur:
Bioss
Description:
Cannabinol (CBN) is a weakly psychoactive cannabinoid found in <i>Cannabis sativa</i> and <i>Cannabis indica</i>. It is also a metabolite of tetrahydrocannabinol (THC). CBN acts as a weak agonist of CB1 receptors but has a higher affinity to CB2 receptors, with lower affinities in comparison to THC. Because of its somewhat selective CB2 agonism, it is used experimentally as an immunosuppressant.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1240R-HRP)
Fournisseur:
Bioss
Description:
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11485R-A680)
Fournisseur:
Bioss
Description:
Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1572R-HRP)
Fournisseur:
Bioss
Description:
May supply copper to copper-requiring proteins within the secretory pathway, when localised in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalised to the plasma membrane where it functions in the efflux of copper from cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1573R-A555)
Fournisseur:
Bioss
Description:
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Isoform 3 fails to show any growth-inhibitory or apoptotic activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7873R-CY5)
Fournisseur:
Bioss
Description:
The protein encoded by this gene is a member of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on chromosome 1q21. This protein may have atumor suppressor function. Chromosomal rearrangements and alteredexpression of this gene have been implicated in breast cancer.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7873R-HRP)
Fournisseur:
Bioss
Description:
The protein encoded by this gene is a member of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on chromosome 1q21. This protein may have atumor suppressor function. Chromosomal rearrangements and alteredexpression of this gene have been implicated in breast cancer.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1572R-FITC)
Fournisseur:
Bioss
Description:
May supply copper to copper-requiring proteins within the secretory pathway, when localised in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalised to the plasma membrane where it functions in the efflux of copper from cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5244R-A647)
Fournisseur:
Bioss
Description:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5244R-CY5.5)
Fournisseur:
Bioss
Description:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9686R-A350)
Fournisseur:
Bioss
Description:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5244R-A350)
Fournisseur:
Bioss
Description:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5123R-CY7)
Fournisseur:
Bioss
Description:
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1774R-A750)
Fournisseur:
Bioss
Description:
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
UOM:
1 * 100 µl
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