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Bioss
Numéro de catalogue:
(BOSSBS-9319R-CY5.5)
Fournisseur:
Bioss
Description:
NNF1R, also called PMF1, is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. It is required for chromosome congression and for correct operation of the spindle checkpoint. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5447R-A647)
Fournisseur:
Bioss
Description:
When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12316R-CY3)
Fournisseur:
Bioss
Description:
Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12317R-A350)
Fournisseur:
Bioss
Description:
SCUBE3 is a novel secreted 993 amino acid cell-surface osteoblast protein that plays an important role in bone cell biology. While highly expressed in osteoblasts, SCUBE3 expression is unobservable or very low in non-bone tissues. SCUBE3 forms homo-oligomers and hetero-oligomers with SCUBE1, and may undergo C-terminal proteolytic cleavage or become N-glycosylated following translation. Two SCUBE3 isoforms exist as a result of alternative splicing events. SCUBE3 contains one CUB domain and nine EGF-like domains, and is encoded by a gene which maps to human chromosome 6p21.31, a region associated with a rare form of metabolic bone disease known as Paget's disease. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9208R-A488)
Fournisseur:
Bioss
Description:
Centrosomes are dynamic organelles involved in many aspects of cell function and growth. Centrosomes act as microtubule organizing centers, and provide a site for concerted regulation of cell cycle progression. Duplication of centrosomes occurs once during each cell cycle and requires proper mitotic spindle formation and chromosome segregation. Defects in centrosome duplication or function are linked to many human diseases, including various forms of cancer. The centrosome and spindle pole-associated protein 1 (CSPP1) interacts with centrosomes and microtubules and may play a role in the regulation of G(1)/S-phase progression and spindle assembly. Two isoforms of CSPP1 exist as a result of alternative splicing events. Isoform 1 expression increases throughout the cell cycle and peaks in G2/M phase, whereas isoform 2 expression is highest in G1 phase and decreases thereafter.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5109R-HRP)
Fournisseur:
Bioss
Description:
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6117R-HRP)
Fournisseur:
Bioss
Description:
May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2361R-CY7)
Fournisseur:
Bioss
Description:
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6119R-CY3)
Fournisseur:
Bioss
Description:
May be involved in the regulation of cellular proliferation and/or differentiation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2487R-CY3)
Fournisseur:
Bioss
Description:
May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6119R-FITC)
Fournisseur:
Bioss
Description:
May be involved in the regulation of cellular proliferation and/or differentiation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2487R-A555)
Fournisseur:
Bioss
Description:
May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1349R-A680)
Fournisseur:
Bioss
Description:
FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C terminal death domain that interacts with the Fas receptor death domain. The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through self-cleavage. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11031R-A647)
Fournisseur:
Bioss
Description:
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6926R-CY5)
Fournisseur:
Bioss
Description:
CCDC125, also known as KENAE, is a 511 amino acid protein expressed as two isoforms produced by alternative splicing and encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11031R-HRP)
Fournisseur:
Bioss
Description:
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 100 µl
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