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ProSci Inc.
Numéro de catalogue:
(PRSI42-656)
Fournisseur:
ProSci Inc.
Description:
Anti-SLC35F5 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI31-300)
Fournisseur:
ProSci Inc.
Description:
The exact functions of CXorf20 remain unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI31-303)
Fournisseur:
ProSci Inc.
Description:
The exact functions of CPNE9 remain unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI31-290)
Fournisseur:
ProSci Inc.
Description:
Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children. The specific function of NP is not yet known.This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI45-054)
Fournisseur:
ProSci Inc.
Description:
Anti-FOXO3 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI26-725)
Fournisseur:
ProSci Inc.
Description:
RDH12 is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. RDH12 also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3755)
Fournisseur:
ProSci Inc.
Description:
BMI-1 Antibody: The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas. BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence. Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells, suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI26-842)
Fournisseur:
ProSci Inc.
Description:
ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4993)
Fournisseur:
ProSci Inc.
Description:
KLRA3 Antibody: KLRA3 (also known as Ly49C) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA3 is thought to be an inhibitory receptor, recognizing peptide -receptive H-2Kb.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5011)
Fournisseur:
ProSci Inc.
Description:
PDCD5 Antibody: Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4999)
Fournisseur:
ProSci Inc.
Description:
KLRA1 Antibody: KLRA1 (also known as Ly49L) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA1 is thought to be an activating receptor, inducing DAP12 phosphorylation in response to antibody-mediated cross-linking of KLRA1 on NK cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5371P)
Fournisseur:
ProSci Inc.
Description:
JMJD1C peptide is used for blocking the activity of JMJD1C antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5401P)
Fournisseur:
ProSci Inc.
Description:
SKA1 peptide is used for blocking the activity of SKA1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5395P)
Fournisseur:
ProSci Inc.
Description:
Prosapip1 peptide is used for blocking the activity of Prosapip1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5407P)
Fournisseur:
ProSci Inc.
Description:
RWDD3 peptide is used for blocking the activity of RWDD3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI51-414)
Fournisseur:
ProSci Inc.
Description:
Anti-LDHA Mouse Monoclonal Antibody
UOM:
1 * 50 µl
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