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ProSci Inc.
Numéro de catalogue:
(PRSI31-192)
Fournisseur:
ProSci Inc.
Description:
NR2F2, an orphan member of the nuclear hormone receptor superfamily, acts as a transcriptional repressor by antagonizing the functions of other nuclear hormone receptors and by actively silencing transcription. However, in certain contexts, NR2F2 stimulates transcription directly. NR2F2, MyoD and p300 interact in a competitive manner, and that increasing amounts of NR2F2 have the ability to reduce the interaction between myoD and p300 invitro. NR2F2 post-transcriptionally regulates myoD activity/function, and that crosstalk between orphan nuclear receptors and the myogenic bHLH proteins has functional consequences for differentiation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-721)
Fournisseur:
ProSci Inc.
Description:
Mouse Interleukin 1 receptor, type II (IL1R2) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. IL-1R2 structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain. It is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Mouse IL1RII shares 59% amino acid sequence homology with human IL1 RII in their extracellular domains. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signalling, whereas the IL-1R2 has no signalling property and acts as a decoy for IL-1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-716)
Fournisseur:
ProSci Inc.
Description:
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defence as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the regulation of systemic energy balance and physiologic and pathologic processes, including immunity and inflammation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-720)
Fournisseur:
ProSci Inc.
Description:
Interleukin-1 receptor type 2 (IL1R2) belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1 receptor type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. IL1R2 is non-signalling receptor forIL1A, IL1B and IL1RN, reduces IL1B activities. IL1R2 serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signalling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralisation of IL1B by secreted/soluble receptors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-635)
Fournisseur:
ProSci Inc.
Description:
CCDC106 promotes the degradation of p53 protein and inhibits its transactivity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-630)
Fournisseur:
ProSci Inc.
Description:
Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-634)
Fournisseur:
ProSci Inc.
Description:
plays a role in initiation of gene silencing at the early stage of viral infection.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXPS-1004)
Fournisseur:
ProSci Inc.
Description:
DARPP-32, a dopamine (DA) and cAMP-regulated ~32k phosphoprotein that is associated with dopaminoceptive neurons bearing D-1 receptors in the basal ganglia. The protein inhibits protein phosphatase I when it is phosphorylated on Thr34. In contrast, when DARPP-32 is phosphorylated on Thr75 the protein acts as an inhibitor of PKA. Phosphorylation of DARPP-32 is thought to play a critical role in the regulation of dopaminergic neurotransmission. In addition, the activity of DARPP-32 is also thought to play important roles in the actions of alcohol, caffeine and Prozac®.
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSIXPS-1006)
Fournisseur:
ProSci Inc.
Description:
Dynamin is a member of a group of nerve terminal proteins called dephosphins that regulate synaptic vesicle endocytosis. Cyclin dependent protein kinase 5 phosphorylates dynamin at Ser774 and Ser778 that are the phosphorylation sites on dynamin phosphorylated in vivo. Phosphorylation of these sites on dynamin is thought to play a key role in synaptic vesicle trafficking.
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSIXPS-1012)
Fournisseur:
ProSci Inc.
Description:
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by beta-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct subunits GluR1-4 and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR1 subunit is widely expressed throughout the nervous system. GluR1 is also potentiated by phosphorylation at Ser831. In addition, phosphorylation of this site has been linked to synaptic plasticity as well and learning and memory.
UOM:
1 * 150 µl
Numéro de catalogue:
(PRSI26-696)
Fournisseur:
ProSci Inc.
Description:
ARL13B has an evolutionarily conserved role mediating cilia function in multiple organs. N and C domains of ARL13B cooperatively regulate its ciliary localization and that N domain-dependent self-association of Arl13b may be important for its function in cilia biogenesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-690)
Fournisseur:
ProSci Inc.
Description:
RP13-102H20.1 is the GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6121)
Fournisseur:
ProSci Inc.
Description:
ZBTB4 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6139)
Fournisseur:
ProSci Inc.
Description:
ZMYM4 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. It has been found to be overexpressed in human lung adenocarcinomas and squamous cell carcinomas, and the overexpression of a fragment of the 3'UTR of the ZMYM4 mRNA termed Cell Death Inhibiting RNA (CDIR) protects HeLa cells from IFN- gamma -induced apoptosis, suggesting that ZMYM4 may play a role in tumorigenesis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6569P)
Fournisseur:
ProSci Inc.
Description:
PIWI-L2 peptide is used for blocking the activity of PIWI-L2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-687)
Fournisseur:
ProSci Inc.
Description:
FAM82A belongs to the FAM82/RMD family. It is a single-pass membrane protein. The function of the FAM82A protein remains unknown.
UOM:
1 * 50 µG
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