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Numéro de catalogue: (PRSI92-479)

Fournisseur:  ProSci Inc.
Description:   Human IL-2RB, also known asinterleukin-2 receptor subunit beta,is the receptor for interleukin-2. IL2 receptor complex is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2 receptor complex has three forms with respect to ability to bind IL2. IL-2RB is belonged to a type I membrane protein,and has a 26 residue signal peptide, a 214 residue extracellular region, a 25 residue transmembrane region and a 286 residue cytoplasmic domain. IL-2RB is the subunit critical for receptor-mediated signalling via physically or functionally coupling to other signalling molecules, such as the Jak-STAT and Src-family protein tyrosine kinase although it lacks apparent catalytic motifs.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI46-369)

Fournisseur:  ProSci Inc.
Description:   Anti-SIGLEC12 Goat Polyclonal Antibody
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI47-107)

Fournisseur:  ProSci Inc.
Description:   Anti-RPA2 Rabbit Polyclonal Antibody
UOM:  1 * 25 µG
Numéro de catalogue: (PRSI48-769)

Fournisseur:  ProSci Inc.
Description:   Anti-S100 A8 Mouse Monoclonal Antibody
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI36-225)

Fournisseur:  ProSci Inc.
Description:   Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI92-139)

Fournisseur:  ProSci Inc.
Description:   Ubiquitin-Conjugating Enzyme E2 C (UBE2C) is a 179 amino acid enzyme that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2C is highly expressed in tumour tissues and at low levels in most adult normal tissues. UBE2C is required for the destruction of mitotic cyclins and for cell cycle progression. UBE2C accepts Ubiquitin from the E1 complex and catalyses its covalent attachment to other proteins. It acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), which has E3 ubiquitin ligase activity, and targets for destruction substrates from the preceding mitosis (Cyclin A, Cyclin B, Securin, Geminin).
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI5023)

Fournisseur:  ProSci Inc.
Description:   SPG15 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. SPG15 is the second gene known to be responsible for ARHSP-TCC in the Italian population. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. SPG15 encodes a protein containing a FYVE zinc finger binding domain which is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. SPG15 mRNA is widely distributed in human tissues, as well as in rat embryos, suggesting a possible role for this protein during embryonic development. SPG15 co-localizes partially with endoplasmic reticulum and endosome markers, suggesting a role in intracellular trafficking. Multiple isoforms of SPG15 are known to exist.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI5501P)

Fournisseur:  ProSci Inc.
Description:   ZNF536 peptide is used for blocking the activity of ZNF536 antibody.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI29-109)

Fournisseur:  ProSci Inc.
Description:   PGBD1 belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. This gene product is specifically expressed in the brain, however, its exact function is not known. Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. This gene product is specifically expressed in the brain, however, its exact function is not known.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI5491P)

Fournisseur:  ProSci Inc.
Description:   SIPA1L1 peptide is used for blocking the activity of SIPA1L1 antibody.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI29-126)

Fournisseur:  ProSci Inc.
Description:   FOXQ1 contains 1 fork-head DNA-binding domain. FOXQ1 mediates the interaction of Akt/protein kinase B with TGFb2. Foxq1 regulates differentiation of hair in satin mice.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI5051)

Fournisseur:  ProSci Inc.
Description:   RCAN2 Antibody: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI5499P)

Fournisseur:  ProSci Inc.
Description:   MARVELD1 peptide is used for blocking the activity of MARVELD1 antibody.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI5495P)

Fournisseur:  ProSci Inc.
Description:   SIPA1L3 peptide is used for blocking the activity of SIPA1L3 antibody.
UOM:  1 * 50 µG
Numéro de catalogue: (PRSI46-611)

Fournisseur:  ProSci Inc.
Description:   Anti-ZDHHC8 Goat Polyclonal Antibody
UOM:  1 * 1 EA
Numéro de catalogue: (PRSI46-600)

Fournisseur:  ProSci Inc.
Description:   Anti-WRNIP1 Goat Polyclonal Antibody
UOM:  1 * 1 EA
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