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ProSci Inc.
Numéro de catalogue:
(PRSI31-098)
Fournisseur:
ProSci Inc.
Description:
The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI31-096)
Fournisseur:
ProSci Inc.
Description:
The nicotinic acetylcholine receptors are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Mutations in neuronal nicotinic acetylcholine receptor beta 2 subunit have been associated with autosomal dominant nocturnal frontal lobe epilepsies.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI31-093)
Fournisseur:
ProSci Inc.
Description:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA7 is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from CHRNA7 and a novel FAM7A gene.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI31-099)
Fournisseur:
ProSci Inc.
Description:
The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-497)
Fournisseur:
ProSci Inc.
Description:
Anti-DRD5 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-483)
Fournisseur:
ProSci Inc.
Description:
Anti-DKC1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-486)
Fournisseur:
ProSci Inc.
Description:
Anti-DKK4 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-457)
Fournisseur:
ProSci Inc.
Description:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localised innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localised inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
UOM:
1 * 25 µG
Numéro de catalogue:
(PRSI35-346)
Fournisseur:
ProSci Inc.
Description:
Anti-Pseudomonas Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
UOM:
1 * 1 mL
Numéro de catalogue:
(PRSI27-360)
Fournisseur:
ProSci Inc.
Description:
ZNF274 is a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus.This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3681P)
Fournisseur:
ProSci Inc.
Description:
ATF6 peptide is used for blocking the activity of ATF6 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3745P)
Fournisseur:
ProSci Inc.
Description:
IL-31 peptide is used for blocking the activity of IL-31 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI49-333)
Fournisseur:
ProSci Inc.
Description:
Simultaneously four different laboratories identified a new member of the tumor necrosis factor (TNF) family. This has been named as TALL-1 , THANK (TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase , BAFF (for B cell activating factor belonging to the TNF family) and Blys (B lymphocyte stimulator). Membrane-bound BAFF is processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. Secreted BLyS/BAFF/THANK acts as a potent B cell growth factor. Overexpression of BLyS/BAFF in transgenic mice lead to increased numbers of mature B and effector T cells. These mice also develop autoimmune like symptoms, such as, high levels of rheumatoid factors, anti-DNA autoantibodies, etc.. Recently, two receptors for BLyS/BAFF have been identified and termed as BCMA and TACI. Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-κB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. BAFF and its receptors are essential for B cell development, survival, and humoral immune responses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI71-130)
Fournisseur:
ProSci Inc.
Description:
Anti-GPC4 Rabbit Polyclonal Antibody
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-379)
Fournisseur:
ProSci Inc.
Description:
Involved in stress resistance and actin organization.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-385)
Fournisseur:
ProSci Inc.
Description:
DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.
UOM:
1 * 1 EA
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