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Anticorps
Numéro de catalogue:
(BOSSBS-4965R-HRP)
Fournisseur:
Bioss
Description:
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8482R-A350)
Fournisseur:
Bioss
Description:
Plays a major role in tight junction-specific obliteration of the intercellular space.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8481R-A680)
Fournisseur:
Bioss
Description:
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesised MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4965R-FITC)
Fournisseur:
Bioss
Description:
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8482R-CY5)
Fournisseur:
Bioss
Description:
Plays a major role in tight junction-specific obliteration of the intercellular space.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4966R-A488)
Fournisseur:
Bioss
Description:
Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8482R-HRP)
Fournisseur:
Bioss
Description:
Plays a major role in tight junction-specific obliteration of the intercellular space.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8482R-CY5.5)
Fournisseur:
Bioss
Description:
Plays a major role in tight junction-specific obliteration of the intercellular space.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6358R-A750)
Fournisseur:
Bioss
Description:
General activator of RNA polymerase which utilises different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1014R-A555)
Fournisseur:
Bioss
Description:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6359R-A350)
Fournisseur:
Bioss
Description:
Phosphoribosyl pyrophosphate amidotransferase (PPAT) is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis. The genes for PPAT and PAICS/AIRC, (a bifunctional enzyme catalyzing steps six and seven in the purine nucleotide biosynthesis pathway), are located in close proximity on chromosome 4.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1014R-A350)
Fournisseur:
Bioss
Description:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6358R-CY3)
Fournisseur:
Bioss
Description:
General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transcription of tRNA, adenovirus VA1, 7SL and 5S RNA. Isoform 2 is required for transcription of the U6 promoter.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15019R-A350)
Fournisseur:
Bioss
Description:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf135 gene product has been provisionally designated C1orf135 pending further characterization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9672R-HRP)
Fournisseur:
Bioss
Description:
Encoding over 300 genes, chromosome 18 contains about 76 million bases. Trisomy 18, or Edwards syndrome, is the second most common trisomy after Downs syndrome. Symptoms of Edwards syndrome include low birth weight, a variety of physical development defects, heart deformations and breathing difficulty. Translocation between chromosome 18 and 14 is the most common translocation in cancers, and occurs in follicular lymphomas. Niemann-Pick disease, hereditary hemorrhagic telangiectasia and erythropoietic protoporphyria are associated with chromosome 18. The TGFβ modulators, Smad2, Smad4 and Smad7 are encoded by chromosome 18. The C18orf54 gene product has been provisionally designated C18orf54 pending further characterization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5286R-A750)
Fournisseur:
Bioss
Description:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors.
UOM:
1 * 100 µl
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