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Anticorps
Numéro de catalogue:
(BOSSBS-12134R-A647)
Fournisseur:
Bioss
Description:
The Ca2+/calmodulin-dependent protein kinases (CaMKs) comprise a structurally related subfamily of serine/threonine kinases. CaMKI Beta (Ca2+/calmodulin-dependent protein kinase type 1B), also known as PNCK (pregnancy up-regulated non-ubiquitously expressed CaM kinase) or BSTK3, is a 343 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one protein kinase domain. Existing as multiple alternatively spliced isoforms, CaMKI Beta functions to catalyze the ATP-dependent phosphorylation of CaMKI, an event that activates CaMKI activity and may be important for Ca2+-triggered signaling cascades within the cell. The gene encoding CaMKI Beta maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8697R-HRP)
Fournisseur:
Bioss
Description:
Connexin 29 belongs to the connexin family and is a member of the epsilon-type subfamily. Connexin 29 is a membrane bound, multi-pass protein also known as gap junction epsilon-1 protein. A connexon, consisting of connexin hexamers, is a membrane bound structure that is integral in the formation of a gap junction. One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low molecular weight diffuse from one cell to a neighboring cell. Connexin 29 expression is restricted to the central nervous system and is present in brain, spinal cord, and sciatic nerve samples. It has been suggested that connexin 29 in the mature CNS contributes minimally to gap junctional intercellular communication in oligodendrocyte cell bodies. Rather, connexin 29 is targeted to myelin where it, along with connexin 32, may contribute to connexin-mediated communication between adjacent layers of uncompacted myelin.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8176R-HRP)
Fournisseur:
Bioss
Description:
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3797R-CY5)
Fournisseur:
Bioss
Description:
surface layer protein
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8457R-A750)
Fournisseur:
Bioss
Description:
AGPD1_HUMAN;Agphd1;Aminoglycoside phosphotransferase domain containing;Aminoglycoside phosphotransferase domain-containing protein 1;C630028N24Rik;OTTMUSP00000025874;RGD1308677.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5027R-HRP)
Fournisseur:
Bioss
Description:
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8057R-A555)
Fournisseur:
Bioss
Description:
KLHL31
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3127R-CY5)
Fournisseur:
Bioss
Description:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6351R-CY3)
Fournisseur:
Bioss
Description:
his gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2621R-A488)
Fournisseur:
Bioss
Description:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3095R-CY5)
Fournisseur:
Bioss
Description:
Cyclin dependent kinases are positively regulated by association with cyclins and negatively regulated by binding to inhibitory subunits. The activity of cyclin dependent kinases is also regulated by the phosphorylation status, which is controlled by the antagonistic action of Wee1 kinase and CDC25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B, and CDC25C. These three genes function at different phases of the cell cycle. Whereas CDC25A and CDC25B are expressed throughout the cell cycle, with peak expression in G1 for CDC25A and in both G1 S phase and G2 for CDC25B, CDC25C is predominantly expressed in G2.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-10471R-A488)
Fournisseur:
Bioss
Description:
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1376R-A350)
Fournisseur:
Bioss
Description:
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6654R-A750)
Fournisseur:
Bioss
Description:
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5958R-CY7)
Fournisseur:
Bioss
Description:
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1944R-HRP)
Fournisseur:
Bioss
Description:
The WRCH1 protein is a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation.
UOM:
1 * 100 µl
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