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Anticorps
Numéro de catalogue:
(BOSSBS-9067R)
Fournisseur:
Bioss
Description:
Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5682R)
Fournisseur:
Bioss
Description:
Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5681R)
Fournisseur:
Bioss
Description:
Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15218R)
Fournisseur:
Bioss
Description:
Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf132 gene product has been provisionally designated C6orf132 pending further characterization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15227R)
Fournisseur:
Bioss
Description:
Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf163 gene product has been provisionally designated C6orf163 pending further characterization.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5229R)
Fournisseur:
Bioss
Description:
Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1; while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.
UOM:
1 * 100 µl
Numéro de catalogue:
(USBI043780-FITC)
Fournisseur:
US Biological
Description:
Anti-VPS54 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI037266-AP)
Fournisseur:
US Biological
Description:
Anti-KLK8 Rabbit Polyclonal Antibody (AP (Alkaline Phosphatase))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI037266-APC)
Fournisseur:
US Biological
Description:
Anti-KLK8 Rabbit Polyclonal Antibody (APC (Allophycocyanin))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI043453-FITC)
Fournisseur:
US Biological
Description:
Anti-TUBB2A Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBIA0928-02F)
Fournisseur:
US Biological
Description:
Anti-FOXO4 Rabbit Polyclonal Antibody
UOM:
1 * 1 EA
Fournisseur:
US Biological
Description:
Anti-ZNF15 Rabbit Polyclonal Antibody
Numéro de catalogue:
(USBIW1002-70C-100)
Fournisseur:
US Biological
Description:
Anti-WBSCR14 Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(USBIV2120-35-100)
Fournisseur:
US Biological
Description:
Anti-AVPR2 Rabbit Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(USBIV3000-100)
Fournisseur:
US Biological
Description:
Anti-PIK3C3 Rabbit Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(BWRLBS3831)
Fournisseur:
Bioworld Technology
Description:
Synthetic peptide, corresponding to amino acids 781-830 of Human CEP290.
UOM:
1 * 1 EA
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