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Anticorps
Numéro de catalogue:
(BOSSBS-2197R-HRP)
Fournisseur:
Bioss
Description:
duck hepatitis A virus genome polyprotein
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13351R-A750)
Fournisseur:
Bioss
Description:
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2405R-A350)
Fournisseur:
Bioss
Description:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4054R-FITC)
Fournisseur:
Bioss
Description:
S adenosylmethionine synthetase catalyzes the formation of S adenosylmethionine from methionine and ATP. In mammalian tissues, there are three distinct forms of AdoMet synthases designated as alpha, beta, and gamma. Alpha and beta are expressed only in adult liver, while gamma is widely distributed in extrahepatic tissues.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8372R-HRP)
Fournisseur:
Bioss
Description:
E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11696R-A647)
Fournisseur:
Bioss
Description:
The Huntingtin protein contains a polyglutamine region, which leads to Huntingtin’s disease (HD) when the number of glutamine repeats exceeds thirty-five. The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), HAP40, Rab5 and HIP1. HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes. Specifically, this complex regulates endosome motility, which may be a key event of the pathogenetic process leading to neurodegeneration in HD.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11696R-A555)
Fournisseur:
Bioss
Description:
The Huntingtin protein contains a polyglutamine region, which leads to Huntingtin’s disease (HD) when the number of glutamine repeats exceeds thirty-five. The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), HAP40, Rab5 and HIP1. HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes. Specifically, this complex regulates endosome motility, which may be a key event of the pathogenetic process leading to neurodegeneration in HD.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11696R-CY3)
Fournisseur:
Bioss
Description:
The Huntingtin protein contains a polyglutamine region, which leads to Huntingtin’s disease (HD) when the number of glutamine repeats exceeds thirty-five. The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), HAP40, Rab5 and HIP1. HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes. Specifically, this complex regulates endosome motility, which may be a key event of the pathogenetic process leading to neurodegeneration in HD.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4177R-A680)
Fournisseur:
Bioss
Description:
Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4250R-HRP)
Fournisseur:
Bioss
Description:
The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11807R-HRP)
Fournisseur:
Bioss
Description:
Aladin (Adracalin) belongs to a family of WD repeat-containing proteins. These proteins have a wide variety of functions, including signal transduction regulation, RNA processing and transcription. Aladin plays a role in peripheral and central nervous system development. It is widely expressed, with the highest expression seen in pituitary gland, corpus callosum, cerebellum, adrenal gland and gastrointestinal structures. Defects in Aladin cause the autosomal recessive disorder achalasia-addisonianism-alacrima (triple A) syndrome. Triple A syndrome is characterized by achalasia, alacrima and adrenocortico-tropin-resistant adrenal insufficiency. Robust expression in neural systems associated with cognitive, motor and sensory functions is consistent with the myriad of symptoms experienced by patients with triple A syndrome.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-14441R-CY3)
Fournisseur:
Bioss
Description:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2937R-A680)
Fournisseur:
Bioss
Description:
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localises to the endoplasmic reticulum and the Golgi apparatus.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-14441R-A647)
Fournisseur:
Bioss
Description:
Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12383R-A750)
Fournisseur:
Bioss
Description:
The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch Signalling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12384R-A750)
Fournisseur:
Bioss
Description:
The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch Signalling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
UOM:
1 * 100 µl
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