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Protéines et Peptides
Fournisseur:
Biorbyt
Description:
Human IL32 alpha (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Human recombinant HSP32 (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Human recombinant IL4 (from <i>E. coli</i>)
Fournisseur:
Biorbyt
Description:
Rat recombinant prolactin
Numéro de catalogue:
(STMC100-0507)
Fournisseur:
STEMCELL Technologies
Description:
FRET-based peptide substrate for detection of protease activity of coronaviruses - 100 tests.
UOM:
1 * 1 EA
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0506)
Fournisseur:
STEMCELL Technologies
Description:
FRET-based peptide substrate for detection of protease activity of coronaviruses - 1000 tests.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Use Interferon beta (IFN-β) to modulate the activity of genes that control dendritic cell activation, T cell survival, NK cell activation, chemokine expression, lymph node retention, and antiproliferative and antiviral effects (Dunn <i>et al.</i> Nat Rev Immunol, 2006). IFN-β binds to a receptor complex composed of IFNAR1 and IFNAR2, and initiates signal transduction via the JAK/STAT pathway. It is predominantly produced by fibroblasts, with smaller amounts from plasmocytoid dendritic cells. Macrophages and endothelial cells secrete IFN-β in response to viral infection (Reder and Feng. Front Immunol, 2013). IFN-β suppresses Th17 cells by affecting expression of IL-4, IL-10, and IL-27, and is a first-line treatment for multiple sclerosis. IFN-β was also shown to expand regulatory T cells and limit T cell trafficking to the central nervous system (Inoue and Shinohara. Immunology, 2013). Of the two IFN-β variants (IFN-β1 and IFN-β3), this product is the IFN-β1 form.
Numéro de catalogue:
(STMC100-0675)
Fournisseur:
STEMCELL Technologies
Description:
The CEF (HLA Class I Control) Peptide pool is a lyophilised mixture of 32 peptides from cytomegalovirus (CMV), Epstein-Barr virus (EBV), and influenza virus. The pool consists of defined HLA class I-restricted T cell epitopes from these three viruses, and can be used as a positive control to stimulate T cells.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC100-0853)
Fournisseur:
STEMCELL Technologies
Description:
Fluorescent dye conjugates for detection of F-actin in cell culture experiments - 300 tests.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0935)
Fournisseur:
STEMCELL Technologies
Description:
Chemokine ligand 19 (CCL19), also known as macrophage inflammatory protein-3 beta (MIP-3β), is a member of the CC chemokine family, which plays key roles in inflammatory responses, T cell activation, homeostasis, and development (Yan <i>et al.</i>). CCL19 is expressed in lymph nodes, thymus, and activated bone marrow stromal cells; it binds to C-C motif chemokine receptor 7 (CCR7) to induce migration of macrophages, T cells, and B cells (Gibejova <i>et al.</i>). Clinically, the expression of CCL19 is correlated to autoimmune diseases such as rheumatoid arthritis and cancer (Pickens <i>et al.</i>; Zhang <i>et al.</i>).
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma <i>et al.</i>). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau <i>et al.</i>). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).
Numéro de catalogue:
(STMC78111.1)
Fournisseur:
STEMCELL Technologies
Description:
Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) subclass of the transforming growth factor beta (TGF-β) superfamily. It binds a receptor complex comprising BMPR1B and BMPR2, which then activates the SMAD signaling pathway (Carreira <i>et al.</i>; Nishitoh <i>et al.</i>; Osório <i>et al.</i>). GDF-5 enhances chondrogenic differentiation of mesenchymal stem cells, skeletogenesis, and dendrite growth during development (Coleman <i>et al.</i>; Francis-West <i>et al.</i>). Studies in rat demonstrated that GDF-5 regulates patterning, neurogenesis, astrogliogenesis, and neuronal specification (Gajavelli <i>et al.</i>; Krieglstein <i>et al.</i>; O’Keeffe <i>et al.</i>).
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
CD40 ligand is a type II transmembrane glycoprotein that belongs to the tumor necrosis factor (TNF) superfamily (Quezada <i>et al.</i>). CD40 ligand forms a bioactive homotrimer that exists as both soluble and membrane-bound forms (Khandekar <i>et al.</i>). CD40 ligand is expressed on T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells. Its receptor, CD40, is expressed on B cells, dendritic cells, macrophages, monocytes, platelets, endothelial cells, and epithelial cells (van Kooten and Banchereau). Binding of CD40 ligand to CD40 stimulates B cell proliferation, immunoglobulin class switching, antibody secretion, and T cell-dependent humoral responses. Dysregulation of CD40 ligand contributes to immune deficiency in HIV and AIDS (Rickert <i>et al.</i>). CD40 ligand has also been linked to the pathology of atherosclerosis, atherothrombosis, and restenosis (Hassan <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 10 (FGF-10) is a member of the fibroblast growth factor (FGF) family which is predominantly expressed by mesenchymal fibroblasts during embryonic development (Emoto <i>et al.</i>; Igarashi <i>et al.</i>). It binds with high affinity to fibroblast growth factor receptor 2-IIIb (FGFR2-IIIb), and also has a weaker affinity for FGFR1-IIIb (Beer <i>et al.</i>). FGF-10 and FGF-7 have similar receptor binding properties and target cell specificities but are differentially regulated by components of the extracellular matrix (Emoto <i>et al.</i>; Igarashi <i>et al.</i>). FGF-10 has been shown to mediate epithelial-mesenchymal interactions, which are essential to lung development (Sekine <i>et al.</i>; Ware and Matthay). FGF-10 also has a role in mobilisation and proliferation of lung-resident mesenchymal stem cells (MSCs) and protection and repair against acute lung injury (Tong <i>et al.</i>; Ware and Matthay) and endodermal differentiation of human pluripotent stem cells to insulin-producing pancreatic-like cells (Takeuchi <i>et al.</i>). This product is animal component-free.
Numéro de catalogue:
(STMC78184.1)
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 6 (FGF-6) is a heparin-binding member of the FGF family, regulators of cell proliferation, differentiation, and function. FGF-6 binds and signals through the FGF receptors 1c, 2c, and 4 (Ornitz <i>et al.</i>). FGF-6 is a potent mitogen for fibroblasts, vascular endothelial cells, and prostate carcinoma cells (Asada <i>et al.</i>; Pizette <i>et al.</i>; Ropiquet <i>et al.</i>). FGF-6 is primarily expressed in epithelial and mesenchymal cell lineages. During development, FGF-6 is expressed in skeletal muscle, consistent with its role in muscle differentiation and regeneration (Floss <i>et al.</i>). FGF-6 has also been shown to promote chondrogenesis in embryonic somites in conjunction with transforming growth factor beta 2 (TGF-β2; Grass <i>et al.</i>).
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Vascular endothelial growth factor (VEGF-165) is a heparin-binding homodimeric glycoprotein involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 (R1) and VEGFR-2 (R2), and activates Raf/MEK/ERK and PI3K/AKT pathways (Ferrara <i>et al.</i>). It plays an important role in neurogenesis both in vitro and <i>in vivo</i> (Storkebaum <i>et al.</i>). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara <i>et al.</i>). VEGF-165 contains two polypeptide chains of 165 amino acids each. This product is animal component-free.
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