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Protéines et Peptides
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 8A (FGF-8A) is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. FGF-8A binds the FGF receptor (FGFR) and activates Ras/MAPK signaling (Hulstrand and Houston). The FGF family possesses broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and is involved in a variety of biological processes, including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). FGF-8 RNA is spliced to produce 4 protein isoforms in humans: FGF-8A, FGF-8B, FGF-8E, and FGF-8F. The functional differences are not fully understood; however, studies in zebrafish and Xenopus show that FGF-8A is required for endoderm morphogenesis and neurogenesis (Choe and Crump; Hulstrand and Houston).
Fournisseur:
STEMCELL Technologies
Description:
Transforming growth factor-alpha (TGF-α) a member of the epidermal growth factor (EGF) family that is expressed in normal epithelial cells, monocytes, macrophages, brain cells, keratinocytes, and cancer cells. TGF-α binds EGF receptor (EGFR) and activates tyrosine kinase signaling. In epidermal and epithelial cells, this results in proliferation and differentiation. TGF-α is not structurally or genetically related to TGF-β, and the two ligands act through different signaling pathways. In vitro, TGF-α was shown to stimulate anchorage-independent growth (Singh and Coffey).
Numéro de catalogue:
(ACRBDN1-C52H9-1MG)
Fournisseur:
ACROBIOSYSTEMS
Description:
Cynomolgus recombinant DNAM-1 (from HEK293)
UOM:
1 * 1 mg
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
ACROBIOSYSTEMS
Description:
Human recombinant integrin alpha 11 beta 1 (from HEK293)
Fournisseur:
ACROBIOSYSTEMS
Description:
Human recombinant PD-1 (from HEK293)
Fournisseur:
ACROBIOSYSTEMS
Description:
Human recombinant Fc gamma RIIIB / CD16b (NA1) (from HEK293)
Fournisseur:
ACROBIOSYSTEMS
Description:
Human recombinant Fc gamma RIIIB/ CD16b (NA1) (from HEK293 cells)
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor (Gaffen and Liu). It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132. Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival (Ma <i>et al.</i>). The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts. IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ regulatory T cells, and affects development of follicular helper T cells. IL-2 also controls inflammation by inhibiting Th17 differentiation (Banchereau <i>et al.</i>). High IL-2 levels in serum are associated with progression of scleroderma, rheumatoid arthritis, and gastric and non-small cell lung cancer, though no known disease can be directly attributed to the lack or excess of IL-2 (Gaffen and Liu).
Fournisseur:
STEMCELL Technologies
Description:
Basic fibroblast growth factor (bFGF) is a prototypic member of the fibroblast growth factor family. Cytokines in the FGF family possess broad mitogenic and cell survival activities (Folkman and Klagsbrun; Kimelman and Kirschner) and are involved in a variety of biological processes including cell proliferation, differentiation, survival, and apoptosis (Folkman and Klagsbrun; Klagsbrun; Rifkin and Moscatelli). bFGF has the β-trefoil structure (Ponting and Russell), binds to the four FGF receptor (FGFR) family members, and activates JAK/STAT, PI3K, ERK1/2, and other receptor tyrosine kinase (RTK) signaling pathways. It supports the maintenance of undifferentiated human pluripotent stem cells (Xu <i>et al.</i>; Kang <i>et al.</i>), stimulates human pluripotent stem cells to form neural rosettes (Zhang <i>et al.</i>), and improves proliferation of human mesenchymal stem cells and enhances chondrogenic differentiation (Solchaga <i>et al.</i>). This version of bFGF is the full-length bFGF protein encoded by the human FGF2 gene consisting of 154 amino acid residues. This product is animal component-free.
Numéro de catalogue:
(STMC78108.1)
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor 21 (FGF-21) is a member of the FGF family. Using β-Klotho as a cofactor, FGF-21 signals through FGF receptor 1c and 4 to activate PI3K and MAPK pathways (Mattila and Härkönen; Kharitonenkov <i>et al.</i>). FGF-21 expression is regulated by tissue-specific peroxisome proliferator-activated receptors (PPARs). Upon PPAR-α stimulation FGF-21 is produced in the liver, and activation of PPAR-γ leads to FGF-21 production in adipose tissue. FGF-21 promotes insulin-independent glucose uptake and lipid accumulation in primary human adipocytes and in mouse 3T3-L1 cells. In pancreatic islets and INS-1 cells it inhibits glucose-mediated glucagon release and stimulates insulin production. FGF-21 does not induce proliferation in immortalized cell lines, unlike other FGFs (Kharitonenkov and Shanafelt). FGF-21 regulates thermogenesis in white and brown adipose tissue, and metabolic processes in cells of pancreatic origin (Kharitonenkov <i>et al.</i>).
UOM:
1 * 1 EA
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Numéro de catalogue:
(STMC100-0934)
Fournisseur:
STEMCELL Technologies
Description:
R-Spondin-3 is a member of thrombospondin type 1 repeat (TSR-1) superfamily that is involved in the canonical Wnt/β-catenin signaling pathway (de Lau <i>et al.</i>). R-spondin proteins are characterized by two furin-like repeats at the amino terminus and thrombospondin domain located near the carboxyl terminus (de Lau <i>et al.</i>). R-spondin-3 expression is associated with ovarian cancer (Gu <i>et al.</i>), prostate cancer (Mesci <i>et al.</i>), and differentiation of intestinal epithelial cells in diabetes mellitus (Shan <i>et al.</i>). In a transgenic mice model, the expression of R-Spondin-3 induces the expansion of Lgr5+ stem cells, Paneth cells, and Lgr4+ cells, promoting the intestinal stem cell compartment (Hilkens <i>et al.</i>). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0943)
Fournisseur:
STEMCELL Technologies
Description:
Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson <i>et al.</i>). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda <i>et al.</i>). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon <i>et al.</i>). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey <i>et al.</i>). RANKL is involved in osteoclastogenesis (Lacey <i>et al.</i>; Yasuda <i>et al.</i>) and T cell activation (Wong <i>et al.</i>). This product is animal component-free.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
ACROBIOSYSTEMS
Description:
Human recombinant B7-H3 (from HEK293)
Numéro de catalogue:
(ACRBFL4-M5251100UG)
Fournisseur:
ACROBIOSYSTEMS
Description:
Mouse recombinant VEGF R3 (from HEK293)
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1400)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with JCV (VP1) Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This peptide pool is a lyophilised mixture of 86 peptides from major capsid protein VP1 (VP1) of the JC polyomavirus (JCV), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 354 on VP1. VP1 binds LSTc oligosaccharides found on host cell glycoproteins and glycolipids, and this interaction is said to be essential for JCV viral growth and infectivity (Neu <i>et al.</i>). The JCV VP1 (Del Valle <i>et al.</i>) and large T antigen (LT) (Delbue <i>et al.</i>) are detected in JCV-associated pathologies such as progressive multifocal leukoencephalopathy (PML) in patients with HIV. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
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Numéro de catalogue:
(STMC100-1334)
Fournisseur:
STEMCELL Technologies
Description:
Macrophage inflammatory protein-4 (MIP-4) plays a role in adaptive and innate immune responses, acting as a chemoattractant for T and B lymphocytes, and natural killer cells (Krohn <i>et al.</i>). MIP-4 can also induce immune tolerance through its effects on dendritic cells and macrophages (Azzaoui <i>et al.</i>, Schraufstatter <i>et al.</i>). In breast cancer, MIP-4 has been shown to promote the invasiveness and metastasis of cancer cells in vivo by binding PITPNM3 (Chen <i>et al.</i>).This small cytokine belongs to the chemokine family found only in primates. Based on amino acid sequence, MIP-4 is closely related to MIP-1 alpha (CCL3) and MIP-1 beta (CCL4) (Liang <i>et al.</i>). MIP-4 is produced by antigen-presenting immune cells including dendritic cells, macrophages, and monocytes (Lieshout <i>et al.</i>). For consistency and reproducibility across your applications, macrophage inflammatory protein-4 from STEMCELL comes lyophilised with ≥95% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1,0 EU/μg protein.
UOM:
1 * 1 EA
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
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