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Numéro de catalogue: (BOSSBS-0251R-CY5.5)

Fournisseur:  Bioss
Description:   Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-0251R-CY5)

Fournisseur:  Bioss
Description:   Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-0251R-A750)

Fournisseur:  Bioss
Description:   Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
UOM:  1 * 100 µl
Fournisseur:  Metro International
Description:   The open wire design of these heavy-gauge shelves minimizes dust accumulation and allows a free circulation of air, greater visibility of stored items and greater light penetration.
Promotion
Numéro de catalogue: (BOSSBS-11597R-A350)

Fournisseur:  Bioss
Description:   Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-11597R-A555)

Fournisseur:  Bioss
Description:   Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-11958R-CY5)

Fournisseur:  Bioss
Description:   Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-11958R-CY3)

Fournisseur:  Bioss
Description:   Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively.
UOM:  1 * 100 µl

Fournisseur:  Bioss
Description:   Transcription factors, OTX1 and OTX2, are two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q21-q22, respectively.
UOM:  1 * 100 µl
Fournisseur:  DWK Life Sciences
Description:   DURAN® clear borosilicate glass 3.3, vacuum desiccator with Mobilex screw thread in the lid with stopcock. With desiccator base with flat flange, no outlet, PBT screw cap with pierced aperture GL 32.

Fournisseur:  2MAG
Description:   Systèmes d'agitation ultra-plats pour un mélange précautionneux des cultures cellulaires. Adaptés aux flacons de culture avec systèmes d'agitateurs et de billes de rotation. Le boîtier en acier inoxydable fermé hermétiquement est étanche à l'eau, résistant aux poussières et aux germes. Températures de fonctionnement jusqu'à 50 °C.
UOM:  1 * 1 ST
Fournisseur:  VWR Collection
Description:   La famille de thermocycleurs VWR® associe une ingénierie de haute qualité à une gamme complète de formats de blocs. Le thermocycleur UNO est conçu autour d'une interface logicielle puissante, mais facile à utiliser, et utilise la même plateforme pour les formats 96 puits et 384 puits. Le Doppio, qui regroupe deux blocs 48 puits indépendants haute vitesse dans un système, offre la solution optimale pour une flexibilité maximale dans un encombrement minimal. En raison de la conception spéciale du couvercle chauffant, la hauteur s’adapte automatiquement aux différentes tailles de tube.
Numéro de catalogue: (444-0344)

Fournisseur:  GRANT INSTRUMENTS
Description:   Plateforme plate avec tapis de caoutchouc antidérapant pour boîtes de Petri, flacons de culture, L×P : 219×219 mm
UOM:  1 * 1 ST
Fournisseur:  Heidolph Instruments GmbH & Co.KG
Description:   Pour un mélange vigoureux des microplaques de titrage. L'amplitude de vibration de 1,5 mm garantit l'absence d'éclaboussures, même avec des récipients pleins ; celle de 3 mm assure des résultats de mélange optimaux, même en quantités infimes. Les agitateurs conçus pour une utilisation continue sont équipés d'une protection anti-surchauffe et d'une plate-forme isolée pour une accumulation de chaleur quasi nulle.
Numéro de catalogue: (METO1824DRC)

Fournisseur:  Metro International
Description:   The heavy-duty dunnage shelves enhance the weight bearing capacity the system.
UOM:  1 * 1 ST
Numéro de catalogue: (BELAF189380000)

Fournisseur:  Bel-Art Products, a Part of SP
Description:   L'aliquotage précis et répétitif dans des puits de microplaques est simplifié en plaçant la plaque sur le pied réglable et en définissant la pente à un angle optimal. La plaque inclinée permet à l'utilisateur de savoir quels puits ont reçu des aliquotes en contrastant de manière visible les ménisques entre les puits voisins.
UOM:  1 * 1 ST
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