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Ace+Method+Development+Kits
Numéro de catalogue:
(BSENM-006-100)
Fournisseur:
Biosensis
Description:
Monoclonal antibody MC192 against the rat low affinity nerve growth factor receptor (p75NTR) is derived from the fusion of Sp2/0-Ag 14 myeloma cells with mouse immune splenocytes. MC192 monoclonal antibody was originally generated by Chandlers et al. p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. MC192 recognizes the extracellular domain of the neurotrophin receptor p75NTR in rat. MC192 antibody may be used for immunocytochemical localisation of rat cells expressing p75NTR, ELISA and western blot. This antibody has also been used for the construction of the MC192-saporin immunotoxin for specific elimination of neuronal populations in basal forebrain cholinergic neurons to generate an animal model for Alzheimer's disease. Using Flow Cytometry, this antibody has frequently been employed for panning to isolate p75NTR-expressing rat cells. MC192 has a potential use as the ligand for gene delivery into p75NTR-expressing rat cells via a receptor-mediated mechanism. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (By similarity). Interacts with BEX1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-803)
Fournisseur:
ProSci Inc.
Description:
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. MEIS1 is a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-894)
Fournisseur:
ProSci Inc.
Description:
Zinc is an essential cofactor for more than 50 classes of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and from intracellular storage compartments.Zinc is an essential cofactor for more than 50 classes of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and from intracellular storage compartments.
UOM:
1 * 50 µG
Fournisseur:
VWR Chemicals
Description:
Les matériaux de référence certifiés pour déterminer la densité permettent de vérifier des instruments de laboratoire destinés à tester le pétrole et ses produits dérivés en déterminant la densité, par exemple selon des méthodes telles ASTM D4052, IP 365 ou d'autres méthodes d'essai équivalentes.
Numéro de catalogue:
(PRSI38-177)
Fournisseur:
ProSci Inc.
Description:
Wnt3a is a secreted ligand for members of the Frizzled family of receptors. It is one of the closely-related Wnt family and has multiple roles in development and cell fate.
UOM:
1 * 1 EA
Fournisseur:
Merck Millipore (Calbiochem)
Description:
Elastase, human neutrophil is a serine protease that degrades elastin, collagen, and proteoglycans. Its overexpression has been implicated in the development of pulmonary emphysema, rheumatoid arthritis, and cystic fibrosis.
Numéro de catalogue:
(PRSI25-932)
Fournisseur:
ProSci Inc.
Description:
Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A5 belongs to a subfamily of proteins that show structural characteristics of zinc transporters.Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A5 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-890)
Fournisseur:
ProSci Inc.
Description:
SLC2A9 is a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. SLC2A9 may play a role in the development and survival of chondrocytes in cartilage matrices.This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene.
UOM:
1 * 50 µG
Numéro de catalogue:
(AATB21219)
Fournisseur:
AAT BIOQUEST INC
Description:
The amino-reactive Protonex™ Green 500 SE (#21216) was developed for preparing Protonex™ Green 500 conjugates as fluorescent pH probes.
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(PRSI27-836)
Fournisseur:
ProSci Inc.
Description:
FOXL2 is a member of the forkhead family. The forkhead domain is a monomeric DNA binding motif that defines a rapidly growing family of eukaryotic transcriptional regulators. Genetic and biochemical data suggest a central role in embryonic development for forkhead proteins.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI27-312)
Fournisseur:
ProSci Inc.
Description:
PBX1 binds the sequence 5'-ATCAATCAA-3'. It acts as a transcriptional activator of PF4 in complex with MEIS1. It may be converted into a potent transcriptional activator by the (1;19) translocation. It also may have a role in steroidogenesis and, subsequently, sexual development and differentiation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-545)
Fournisseur:
ProSci Inc.
Description:
FOXL1 is a member of the forkhead family. The forkhead domain is a monomeric DNA binding motif that defines a rapidly growing family of eukaryotic transcriptional regulators. Genetic and biochemical data suggest a central role in embryonic development for forkhead proteins.
UOM:
1 * 1 EA
Fournisseur:
LGC Standards PROMOCHEM
Description:
EPA Method 23 calibration solutions [CS1-CS5], 0,2 ml in nonane, : N/A
Numéro de catalogue:
(PRSI30-556)
Fournisseur:
ProSci Inc.
Description:
LRRC8 is a multi-pass membrane protein. It contains 13 LRR (leucine-rich) repeats. LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI25-431)
Fournisseur:
ProSci Inc.
Description:
TEAD2 contains 1 TEA DNA-binding domain. TEAD2 is a putative transcription factor that binds to the SPH and GT-IIC enhansons (5'-GTGGAATGT-3'). It may be involved in the gene regulation of neural development.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-396)
Fournisseur:
ProSci Inc.
Description:
FOXF1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.
UOM:
1 * 1 EA
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