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Fournisseur:  Bioss
Description:   Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling. Regulates cell adhesion and cell spreading. Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity.
UOM:  1 * 100 µl
Fournisseur:  Corning
Description:   Axygen® ImpermaMat sealing mats minimize evaporation in a wide range of temperatures in PCR and storage applications. ImpermaMats are chemically resistant, reusable sealing mats, that provide a high degree of confidence.
Fournisseur:  SP Industries
Description:   NMR tubes, economy, 5 mm, borosilicate glass ASTM E438, Type I, class B, with disposable cap.

Fournisseur:  THERMO SAVANT EC
Description:   Thermo Scientific™ Savant™ SpeedVac™ SPD1030 vacuum concentrators are fully integrated systems that combine a concentrator, refrigerated cold trap, diaphragm pump and a vacuum gauge into a single, compact unit.
UOM:  1 * 1 ST
Numéro de catalogue: (WILMLG-10800-100)

Fournisseur:  SP Industries
Description:   Tube incorporates a grease-free high vacuum 0 to 4 mm valve and is suited for pressure/vacuum applications. Ideal for reaction and storage of air-sensitive compounds. Sidearm can be connected to inert atmosphere/vacuum source or a manifold.
UOM:  1 * 1 ST
Numéro de catalogue: (PRSI6973)

Fournisseur:  ProSci Inc.
Description:   TCIRG1 Antibody: The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump in late endosomes and lysosomes that functions in the luminal acidification of these organelles. Genetic defects in the gene encoding this protein a responsible for a severe form of autosomal recessive osteopetrosis, a condition that leads to increased bone density, decreased bone strength, and inflammation in bone tissues. TCIRG1 is also required for the normal secretion of insulin and the bacteria-killing function of macrophages.
UOM:  1 * 1 EA
Fournisseur:  Merck
Description:   SPE tube adapter, for 1, 3 and 6 ml tubes
Fournisseur:  MACHEREY-NAGEL
Description:   These ready-to-use Flash cartridges are designed for use in the Teledyne Isco® Companion® and other Teledyne Isco® CombiFlash® systems without additional connectors or capillaries or as stand-alone version for any pump/detector combinations.
Fournisseur:  AMARELL, ARNO
Description:   These immersion thermometers are suitable for government verification and calibration.
Fournisseur:  VWR Collection
Description:   PP, haute résistance aux rayons gamma, conique, avec capuchon plat en PEHD.
Environmentally Preferable
Numéro de catalogue: (PEAK3300843)

Fournisseur:  PEAK SCIENTIFIC
Description:   The Precision Hydrogen 1200 is the first 1L+ Hydrogen generator and it is designed to produce hydrogen at a flow of 1200 ml with up to 99,9995% purity. Precision 1200 H₂ generator provides the gas needed for detectors requiring Hydrogen fuel gas, such as FID, NPD and SCD, and it can also support GC carrier gases. One generator is capable of supplying multiple detectors, and is available in various flow rates to ideally suit individual customers’ needs.
UOM:  1 * 1 ST

Fournisseur:  DWK Life Sciences
Description:   Pompe à air en caoutchouc, Pour: Automatic burettes, Pellet pattern
UOM:  1 * 1 ST
Numéro de catalogue: (PRSI29-801)

Fournisseur:  ProSci Inc.
Description:   Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. COX4I1 is the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme.Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.
UOM:  1 * 1 EA
Fournisseur:  Ludwig Schneider GmbH & CO. KG
Description:   API Hydromètres de précision avec thermomètre à liquide bleu intégré.
Fournisseur:  SMEG S.P.A.
Description:   The laboratory glassware washer for washing and disinfecting of glassware and various laboratory material and used for washing up to 95 °C - antibacterical thermal disinfection.
Fournisseur:  Avantor
Description:   Tubings are made of 316 stainless steel.
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