Single-use+Pressure+Sensor
Numéro de catalogue:
(BOSSBS-13627R-A647)
Fournisseur:
Bioss
Description:
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter’s syndrome which is characterized by renal salt-wasting and low blood pressure.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13627R-A350)
Fournisseur:
Bioss
Description:
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter’s syndrome which is characterized by renal salt-wasting and low blood pressure.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6796R-A350)
Fournisseur:
Bioss
Description:
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13627R-HRP)
Fournisseur:
Bioss
Description:
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter’s syndrome which is characterized by renal salt-wasting and low blood pressure.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13627R-A488)
Fournisseur:
Bioss
Description:
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter’s syndrome which is characterized by renal salt-wasting and low blood pressure.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13627R-A555)
Fournisseur:
Bioss
Description:
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter’s syndrome which is characterized by renal salt-wasting and low blood pressure.
UOM:
1 * 100 µl
Numéro de catalogue:
(612-0147)
Fournisseur:
B. Braun
Description:
Aiguille en acier chrome-nickel inoxydable avec surface extrêmement lisse et revêtement en silicone léger, embout de verrouillage Luer en PP transparent
UOM:
1 * 100 ST
Fournisseur:
DuPont
Description:
Fabriquées à partir d'un tissu léger et durable (inférieur à 450 g par vêtement), les vêtements Tychem® 2000 C utilisent la force du tissu Tyvek® et un revêtement polymérique afin d'offrir une bonne protection contre la perméation d'un large éventail de produits chimiques inorganiques et de dangers biologiques (même sous pression).
Fournisseur:
Merck
Description:
Disponibles avec des particules de silice 2 μm optimisées, ces colonnes UHPLC basées sur Purospher® STAR RP-18e sont idéales pour des applications ultra-rapides pour lesquelles la résolution, la sensibilité et le débit de traitement des échantillons sont essentiels. Elles représentent le choix idéal pour des analyses CQ et un criblage à débit élevé, le contrôle de processus, le développement de méthodes et les applications LC/MS. En raison de leur sélectivité équilibrée, les colonnes UHPLC Purospher® STAR RP-18e couvrent presque toutes les séparations exigeantes avec des chromatogrammes sans traînée de pics. Les colonnes 3 μm Purospher® STAR RP-18e sont recommandées pour les échantillons difficiles, lorsque l'obstruction et la contre-pression posent problème.
Numéro de catalogue:
(ENZOADI905750100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1), V1b (V3), and V2. V1b receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas. V2 receptors in the collecting ducts of the kidneys stimulate adenylyl cyclase activity, regulating the reabsorption of water via aquaporin channels.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(BOSSBS-3964R-CY3)
Fournisseur:
Bioss
Description:
PKA (or cAPK) is a cyclic AMP dependent protein kinase. When activated by the second messenger cAMP, PKA mediates diverse cellular mechanisms, including proliferation, ion transport, regulation of metabolism, plus gene transcription. PKA is comprised of two dimers of two subunits, R (regulatory) and C (catalytic). Two families of R subunit (RI and RII) and three C subunit isoforms (C alpha, C beta, and C gamma) have been identified each possessing distinct cAMP binding properties and resulting in different phosphorylation states. C subunit is activated through autophosphorylation and direct phosphorylation at Thr197 by PDK-1. Tissue specific expression of C gamma, indicates pressure on C gamma during evolution, acting to modulate it in a functionally specific way. Certain amino acid substitutions make C gamma a distinct member of the cAMP dependent subfamily of protein kinases, and suggest that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.
UOM:
1 * 100 µl
Numéro de catalogue:
(514-4092)
Fournisseur:
Cytiva (Formerly Pall Lab)
Description:
Conçues pour fournir un air exempt de bactéries (HEPA) pour les applications stériles. Membrane poreuse fournissant un débit d'air élevé à une pression différentielle faible et permettant d'allonger la durée de vie du filtre.
UOM:
1 * 1 ST
Numéro de catalogue:
(BOSSBS-6796R-A750)
Fournisseur:
Bioss
Description:
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
UOM:
1 * 100 µl
Numéro de catalogue:
(HEWL19246-60560)
Fournisseur:
Agilent
Description:
Back pressure regulator, 1 - 15 psi
UOM:
1 * 1 ST
Numéro de catalogue:
(516-8190)
Fournisseur:
Cytiva (Formerly Pall Lab)
Description:
Pack de fixations à jauge, avec 1 manomètre de 3,2 mm NPT, de 0 - 4,1 bar, 2 tubes cannelés de 6,4 mm de diamètre en PP pour connecteurs de 3,2 mm NPT, 1 raccord en T fileté de 3,2 mm, 1 pince à vis, 2 attaches de tube en acier inoxydable, Pour: Lab tangential flow filtration devices, Ultrasette™
UOM:
1 * 1 ST
Numéro de catalogue:
(116-0281)
Fournisseur:
VWR Collection
Description:
Ces étiquettes, fabriquées à partir d’un film PE et comportant les symboles GHS (Global Harmonized System) répondent aux réglementations pour les substances et les mélanges chimiques. Ces symboles GHS ont remplacé les symboles orange traditionnels (HSID) en 2015 quand le pictogramme sur un carré orange et les phrases R et S ont disparu. Ils sont fondés sur les dangers physiques, pour la santé ou pour l'environnement que présente la substance.
UOM:
1 * 1 ROU
Appel de prix
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Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l' est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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