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Single-use+Temperature+Sensor
Numéro de catalogue:
(BOSSBS-5221R-A350)
Fournisseur:
Bioss
Description:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8444R-A350)
Fournisseur:
Bioss
Description:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8444R-A488)
Fournisseur:
Bioss
Description:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
UOM:
1 * 100 µl
Numéro de catalogue:
(612-1816)
Fournisseur:
GILSON
Description:
Ce support carrousel peut contenir jusqu'à sept pipettes Gilson monocal ou multicanal.
UOM:
1 * 1 ST
Numéro de catalogue:
(BOSSBS-6835R-HRP)
Fournisseur:
Bioss
Description:
The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Numéro de catalogue:
(PRSI91-423)
Fournisseur:
ProSci Inc.
Description:
Junctional Adhesion Molecule A (JAM-A) is a single-pass type I membrane protein that belongs to the immunoglobulin superfamily. JAM-A contains 2 Ig-like V-type (immunoglobulin-like) domains and Interacts with the ninth PDZ domain. JAM-A is localized to the tight junctions of both epithelial and endothelial cells. JAM-A seems to be involved in epithelial tight junction formation. JAM-A appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM-A, thereby preventing tight junction assembly. JAM-A plays a role in regulating monocyte transmigration involved in regulating integrity of the epithelial barrier. In the case of orthoreovirus infection, JAM-A serves as receptor for the virus.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-504)
Fournisseur:
ProSci Inc.
Description:
Amphoterin-Induced Protein 2 (AMIGO2) is a single-pass type I membrane protein which belongs to the AMIGO family of immunoglobulin superfamily. Mature AMIGO2 contains an Ig-like C2-type (immunoglobulin-like) domain, 6 LRR (leucine-rich) repeats, a LRRCT domain, as well as a LRRNT domain. AMIGO2 is mainly expressed in in breast, ovary, cervix, and uterus, although lower in lung, colon, and rectum. AMIGO2 required for depolarization-dependent survival of cultured cerebellar granule neurons. AMIGO2 may mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. AMIGO2 may contribute to signal transduction through its intracellular domain, and may be required for tumorigenesis of a subset of gastric adenocarcinomas.
UOM:
1 * 50 µG
Fournisseur:
VWR Collection
Description:
Convivial grâce à son porte-électrode articulé et son boîtier IP 43, cet instrument offre une haute résolution et une grande fiabilité, permettant d'obtenir des mesures précises. Équipement complet avec sortie USB pour connexion à un ordinateur. Conforme aux BPL.
Numéro de catalogue:
(BSBTPB9168)
Fournisseur:
BosterBio
Description:
Polyclonal antibody for CD79A detection. Host: Rabbit.Size: 100μg/vial. Tested applications: IHC-P. Reactive species: Human. CD79A information: Molecular Weight: 25038 MW; Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts; Tissue Specificity: B-cells.
UOM:
1 * 1 EA
Fournisseur:
HAMILTON BONADUZ
Description:
Hamilton SoftGrip pipettes are available as 8-channel and 12-channel adjustable volume manual pipettes in two volume ranges covering 5 to 50 µl and 30 to 300 µl.
Numéro de catalogue:
(BSBTPB9247)
Fournisseur:
BosterBio
Description:
Polyclonal antibody for 575 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: Flow Cytometry. Reactive species: Human. 575 information: Molecular Weight: 42200 MW; Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Melanosome . Colocalizes with SLC16A1 and SLC16A8. Identified by mass spectrometry in melanosome fractions from stage I to stage IV; Tissue Specificity: Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI26-854)
Fournisseur:
ProSci Inc.
Description:
The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. ALDH3B1 is highly expressed in kidney and lung. The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene encodes a single transcript of 2.8 kb which is highly expressed in kidney and lung. The functional significance of this gene as well as the cellular localization of its product are presently unknown. Two transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 50 µG
Numéro de catalogue:
(BE-401)
Fournisseur:
G-Biosciences
Description:
Le kit des propriétés physiques des protéines est une activité de laboratoire qui permet aux étudiants de se pencher sur les propriétés physiques de différentes protéines. Les étudiants se familiarisent avec la solubilité des protéines et apprennent comment elle est affectée par des paramètres variés, tels que la température, le pH, le sel et la constante diélectrique. Ils assimilent la précipitation des protéines due au pH, à une grande concentration de sel et en présence de solvants organiques, et la dénaturation des protéines résultant d'une température élevée. De plus, le kit démontre dans quelle mesure les non-protéines, comme les détergents, modifient considérablement les propriétés physiques des molécules de protéines, ce qui explique l'importance de ces détergents dans la solubilisation des protéines. Cette activité de laboratoire passe par l'analyse de trois types de protéines pures. Les étudiants modifient ensuite certaines de ces propriétés avec un détergent et réexaminent les propriétés physiques de ces protéines. Ils doivent alors observer comment les propriétés physiques des molécules de protéines peuvent être exploitées pour la purification et la caractérisation des protéines, et appliquer leurs résultats à un échantillon test d'extrait de tissu complexe.
UOM:
1 * 1 KIT
Fournisseur:
WITEG LABORTECHNIK GMBH
Description:
These multi-channel pipettes are designed for comfort over long term repetitive pipetting. 8 or 12 identical volumes for titration plates.
Numéro de catalogue:
(BOSSBS-9045R-CY3)
Fournisseur:
Bioss
Description:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9045R-CY7)
Fournisseur:
Bioss
Description:
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
UOM:
1 * 100 µl
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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