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Anticorps
Fournisseur:
Biotium
Description:
Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Fournisseur:
Biotium
Description:
Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Fournisseur:
Biotium
Description:
This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
Numéro de catalogue:
(USBI036434-FITC)
Fournisseur:
US Biological
Description:
Anti-HAT1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI042765-PE)
Fournisseur:
US Biological
Description:
Anti-TFE3 Rabbit Polyclonal Antibody (PE (Phycoerythrin))
UOM:
1 * 200 µl
Numéro de catalogue:
(USBI150114)
Fournisseur:
US Biological
Description:
Anti-RAN Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(USBI150100)
Fournisseur:
US Biological
Description:
Anti-PPARD Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(BOSSBS-1229R)
Fournisseur:
Bioss
Description:
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1402R)
Fournisseur:
Bioss
Description:
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13452R)
Fournisseur:
Bioss
Description:
Anti-GM2A Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(IMMRIR1175)
Fournisseur:
ImmunoReagents
Description:
The ImmunoReagents' DyLight® 633 conjugates fluoresces red with physical properties comparable to other 633 dyes. DyLight® 633 is ideal for multi-color applications. DyLight® 633 is available as reactive labeling agents and as conjugates of secondary antibodies and biotin-binding proteins for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 638 nm / 658 nm Emission Color = Red (Similar Dyes: Alexa Fluor 633)
UOM:
1 * 0,5 mg
Numéro de catalogue:
(IMMRIR1192)
Fournisseur:
ImmunoReagents
Description:
TRITC (Tetramethylrhodamine isothiocyanate) is a popular rhodamine derivative pink in Colour but emits a red-orange Colour upon Emission at 580 nm. TRITC is frequently paired with FITC in double labeling experiments and conjugated antibodies are often used in immunofluorescence microscopy, flow cytometry, FLISA (fluorescent ELISA) and high throughput screening assays. These conjugates are best excited with the 532 nm spectral line of the He-Ne laser and are also recommended as a second Colour detection reagent in in situ hybridization applications. (Excitation/Emission = 555 nm/580 nm Emission Colour = Orange to Red (Similar Dyes: Alexa Fluor 555, Cy3, DyLight 550).
UOM:
1 * 0,5 mg
Numéro de catalogue:
(IMMRIR1186)
Fournisseur:
ImmunoReagents
Description:
ImmunoReagents’ Horseradish Peroxidase (HRP) antibody conjugates are the most popular conjugates due to their high level of sensitivity, stability, and low costs. HRP conjugates are an ideal choice for use in ELISA, Immunohistochemistry (IHC), and Western blotting experiments.
UOM:
1 * 1 mg
Numéro de catalogue:
(IMMRIR1170)
Fournisseur:
ImmunoReagents
Description:
The ImmunoReagents' DyLight® 594 conjugates generate red fluorescence and shows wide excitation wavelength separation from green fluorophores for multi-color applications with reduced bleedthrough. The physical characteristics of DyLight® 594 are comparable to other 594 dyes. DyLight® 594 is available for use in fluorescence microscopy, flow cytometry, Western blotting, ELISA, high-content screening and other array platforms. Excitation/Emission = 593 nm / 618 nm Emission Color = Red (Similar Dyes: Alexa Fluor 594, Texas Red)
UOM:
1 * 1 mg
Numéro de catalogue:
(IMMRIR1162)
Fournisseur:
ImmunoReagents
Description:
The ImmunoReagents' DyLight® 800 conjugates uses a near-IR fluorphore that is invisible to the naked eye but increases the staining options when using infrared imaging systems. DyLight® 800 has spectral properties that are very similar to other near-IR dyes, including Alexa Fluor 790 and IRDye 800, and has high solubility for maximal incorporation of the dye into the biomolecule of interest. Excitation/Emission = 777 nm / 794 nm Emission Color = Near IR (Similar Dyes: Alexa Fluor 790, IRDye 800)
UOM:
1 * 1 mg
Numéro de catalogue:
(IMMRIR1927)
Fournisseur:
ImmunoReagents
Description:
ImmunoReagents’ Biotinylated antibody conjugates are widely used due to their ability to enhance antibody signal in most immunoassays. Biotinylated secondary antibodies are used in most immunoassay formats (i.e., ELISA, Immunohistochemistry (IHC), and Western blotting). While Biotinylated antibodies by themselves do not produce a signal that can be visualised, biotin has a high affinity and specificity to Streptavidin/Avidin. Using ImmunoReagents’ streptavidin conjugates with biotinylated antibodies results in signal amplification.
UOM:
1 * 1 mg
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