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Anticorps
Numéro de catalogue:
(ENZOENZABS2610100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: WB
Species reactivity: Hamster
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOENZABS2920100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: ELISA, IHC
Species reactivity: Species independent
UOM:
1 * 100 µl
New Product
Numéro de catalogue:
(ENZOENZABS2575000)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Immunoglobulin G (IgG) is an immunoglobulin monomer consisting of two (gamma) heavy chains and two light chains. Each IgG molecule contains two antigen binding domains and a single effector (Fc) domain.
UOM:
1 * 5 mL
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Aurora A, B, and C have emerged as key mitotic regulators of mammalian centrosome function, chromosome segregation and cytokinesis. Aurora B is one of several chromosomal passenger proteins involved in chromosome alignment at the metaphase plate and cytokinesis. Phosphorylation of a threonine residue in the Aurora activation loop (Thr232 in human Aurora B) is believed to be an essential regulatory mechanism in Aurora kinase activation.
Numéro de catalogue:
(ENZOADIKAPST211E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Protein phosphorylation is a complex biochemical process that is regulated by protein kinases that catalyze the transfer of the gamma-P of ATP to a recipient protein that acts as a substrate. This post-translational modification is primarily directed onto serine, threonine, and tyrosine amino acid residues within a protein. Changes in the phosphorylation status of phosphoproteins can alter their biological function, and aberrations in signal transduction cascades have been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders.
UOM:
1 * 1 EA
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
CaMKII (calmodulin-dependent kinase II) is an enzyme which is activated by increases in intracellular Ca2+ ion concentration and it has been proposed to be pivotal in regulating synaptic strength and maturation of synapses during development. This process is thought to be critical in memory and learning and in establishing the specificity of synaptic connections. There are over two dozen alternative splice variants of CaMKII which are encoded by four genes, a, b, g, and d with apparent molecular masses of 50-60 kDa. CaMKII is widely distributed in many tissues, but is highly expressed in brain. Several studies demonstrate that CaMKII is a multifunctional enzyme which modulates the synaptic strength by binding to a subunit of NMDA receptors and promoting the phosphorylation of this NMDA receptor subunit. CaMKII also regulates DLG localization at synapses by co-localization with DLG in the same protein complex. Experimental data suggest that CaMKII is critically involved in the development of morphine tolerance as well as dependence and inhibition of this enzyme may have some therapeutic benefit in the treatment of opiate tolerance and dependence. It also has been demonstrated that d CaMKII isozyme is down-regulated in human tumor cells indicating a role for d CaMKII isozymes in cellular differentiation. Changes in d CaMKII isozyme expression pattern in human hearts during heart failure suggest that CaMKII is important for regulation of heart function. This immunoaffinity purified antibody detects proteins of 50-60 kDa, corresponding to apparent molecular mass of CaMKII isoforms on SDS-PAGE immunoblots, in samples from human, mouse, rat, bovine, hamster, guinea pig, chicken and rabbit origins. Recombinant rat calmodulin-dependent protein kinase II a subunits expressed in sf9 insect cells are also detected. As the sequences of the rat a, d, and g isoforms are conserved over this amino terminus region, this antibody is expected to recognize the d, g and a isoforms. This antibody is not expected to cross-react with the b isoform. Proteins of unknown identity, ~40, 45 and 90 kDa, may be detected on immunoblot analysis with some lysates.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. GSK-3β is also unique in that it requires a substrate that has been phosphorylated by a distinct kinase before it can phosphorylate the substrate. This phosphate priming mechanism explains why phosphorylation of serine 9 inactivates GSK-3β. The phosphorylated serine binds to the GSK-3β priming phosphate position and prevents binding of alternative substrates. In addition to insulin signaling, GSK-3β participates in the Wnt signaling pathway, where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein. In the presence of Wnts, GSK-3β is unable to phosphorylate beta-catenin, which leads to stabilization of beta-catenin. The Wnt pathway inactivates GSK-3β via the proteins, Dishevelled and FRAT, which disrupt the interaction of GSK-3β with axin, beta-catenin, and APC. Clinically, there is considerable interest in GSK-3β inhibitors because they may mimic the effect of insulin or reduce the hyperphosphorylation of Tau that is observed in Alzheimer's Disease.
Fournisseur:
ENZO LIFE SCIENCES
Description:
The Extracellular regulated kinases, Erk-1 and Erk-2, both play a critical role in cellular proliferation. These extracellular kinases, are known to reside downstream of the Mitogen activated protein kinase/Extracellular protein kinases referred to as MEK. Both MEK-1 and MEK-2 phosphorylate and activate Erk on the conserved TEY motif within the activation loop of the kinase.
Numéro de catalogue:
(ENZOADIKAPMA112E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The eukaryotic translation initiation factors (eIFs) regulate translation at the level of messenger RNA engagement by the ribosome. eIF-2alpha promotes the binding of the initiator tRNA to 40S ribosomal subunits, and is a key signaling component of the unfolded protein response (UPR). eIF-4E recruits mRNAs to the eIF4F complex through binding of their 5 N7-methylguanosine cap. eIF-4E binding proteins-1 and -2 are translational repressors, sequestering eIF-4E in conditions of low cellular demand for translation. Their dissociation from eIF-4E is regulated by phosphorylation in response to growth-promoting stimuli.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI10-905)
Fournisseur:
ProSci Inc.
Description:
Anti-ABBV-181 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI10-908)
Fournisseur:
ProSci Inc.
Description:
Anti-ANB-011 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI10-876)
Fournisseur:
ProSci Inc.
Description:
Anti-ARGX-110 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI10-885)
Fournisseur:
ProSci Inc.
Description:
Anti-CDP7766 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI10-858)
Fournisseur:
ProSci Inc.
Description:
Anti-PF-06523435 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI10-906)
Fournisseur:
ProSci Inc.
Description:
Anti-REGN-2810 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI10-860)
Fournisseur:
ProSci Inc.
Description:
Anti-FPA-144 Recombinant Antibody
UOM:
1 * 0,1 mg
New Product
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