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Protéines et Peptides
Numéro de catalogue:
(PRSI92-581)
Fournisseur:
ProSci Inc.
Description:
Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-323)
Fournisseur:
ProSci Inc.
Description:
Fibroblast growth factor 21 (FGF-21) is a member of the fibroblast growth factor family and has been identified as an important regulator of energy metabolism connecting nutrition, growth, reproduction and longevity. FGF-21 lacks the heparin-binding domain of most FGF proteins, allowing its secretion. FGF-21 is abundantly expressed in adipose tissues, liver and pancreas. In adipose tissue, FGF-21 promotes glucose uptake and oxidation and in liver it replenishes on fasting the tissues with fuel on low nutritional supply. It also induces lipolysis and ketogenesis. FGF-21 acts through FGF receptors (FGFR) associated with the auxiliary protein beta-Klotho. Recently, FGF-21 has been reported to interact directly with the brain circadian clock to coordinate activity and reproduction as part of the adaptation to fasting. Due to its multiple functions of normalizing glucose, lipid and energy homeostasis, FGF-21 represents an attractive novel therapy for type 2 diabetes mellitus and obesity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3191P)
Fournisseur:
ProSci Inc.
Description:
CARMA2 peptide is used for blocking the activity of CARMA2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3187P)
Fournisseur:
ProSci Inc.
Description:
CARD8 peptide is used for blocking the activity of CARD8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-224)
Fournisseur:
ProSci Inc.
Description:
ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and amplification and/or overexpression of ErbB2 has been reported associated with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate and ovarian cancers. Rat ERBB2 is an essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. ErbB2 mediates signalling pathways which involve mitogen-activated protein kinase and phosphatidylinositol-3 kinase, this receptor plays a key role in development, cell proliferation and differentiation.
UOM:
1 * 50 µG
Fournisseur:
Thermo Scientific
Description:
Glycylglycine (Gly-Gly)
Numéro de catalogue:
(PRSIXW-RP3212)
Fournisseur:
ProSci Inc.
Description:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 α subunits and 2 rings are composed of 7 β subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-RP3215)
Fournisseur:
ProSci Inc.
Description:
The covalent attachment of prenyl lipids, such as farnesyl or geranylgeranyl groups, by specific transferases is indispensable for the cellular sorting of many proteins. James et al. (1994) identified in hamster a farnesylated protein, called peroxisomal farnesylated protein or PxF, that localized to the outer surface of peroxisomes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3263)
Fournisseur:
ProSci Inc.
Description:
The tetramer binds two molecules of protoheme IV. It is a homotetramer involved in tryptophan catabolism. There is a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-RP3079)
Fournisseur:
ProSci Inc.
Description:
A carboxylic ester + H2O = an alcohol + a carboxylic anion. Homodimer. Cytoplasmic vesicles. There are two major electrophoretic isotypes. The sequence of the ESD*1 variant is shown. Similar to yeast HRE299.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-313)
Fournisseur:
ProSci Inc.
Description:
ESM-1, short from Endothelial cell-specific molecule 1, is expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney. It is a secretory protein, and can be inducted by TNF and IL1B/interleukin-1beta, but not IL4/interleukin-4. This protein plays great roles in angiogenesis, sprouting, and may have potent implications in lung endothelial cell-leukocyte interactions.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6751P)
Fournisseur:
ProSci Inc.
Description:
NKX2-6 peptide is used for blocking the activity of NKX2-6 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-732)
Fournisseur:
ProSci Inc.
Description:
Interleukin-17F (IL-17F) exists in a disulfide-linked heterodimer that belongs to the IL-17 family. IL-17F is expressed in activated, but not resting, CD4+ T-cells and activated monocytes. IL-17F has been shown to stimulate the production of several other cytokines, including IL-6, IL-8, and granulocyte colony-stimulating factor. IL-17F can regulate cartilage matrix turnover and stimulates PBMC and T-cell proliferation. IL-17F is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. Defects in IL-17F are the cause of familial candidiasis type 6 (CANDF6).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7391P)
Fournisseur:
ProSci Inc.
Description:
19 amino acids near the carboxy terminus of human AKT1S1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4445P)
Fournisseur:
ProSci Inc.
Description:
16 amino acids near the carboxy terminus of human RIM2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4433P)
Fournisseur:
ProSci Inc.
Description:
FGF4 peptide is used for blocking the activity of FGF4 antibody.
UOM:
1 * 50 µG
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