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Protéines et Peptides
Numéro de catalogue:
(PRSI92-061)
Fournisseur:
ProSci Inc.
Description:
Methionine Aminopeptidase 1D (METAP1D) is a mitochondrion protein that belongs to the peptidase M24A family. METAP1D is overexpressed at the protein level in colon cancer cell lines and colon tumors as compared to normal tissues. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localization, and eventual degradation of many proteins. METAP1D is also active with zinc, manganese or divalent ions. It may also play an important role in colon tumorigenesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-541)
Fournisseur:
ProSci Inc.
Description:
Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5195P)
Fournisseur:
ProSci Inc.
Description:
CD81 peptide is used for blocking the activity of CD81 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5257P)
Fournisseur:
ProSci Inc.
Description:
THEM2 peptide is used for blocking the activity of THEM2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5265P)
Fournisseur:
ProSci Inc.
Description:
CCDC134 peptide is used for blocking the activity of CCDC134 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5271P)
Fournisseur:
ProSci Inc.
Description:
MAK10 peptide is used for blocking the activity of MAK10 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-630)
Fournisseur:
ProSci Inc.
Description:
Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulphide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2245P)
Fournisseur:
ProSci Inc.
Description:
Caspase-13 peptide is used for blocking the activity of caspase-13 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-318)
Fournisseur:
ProSci Inc.
Description:
Protein FAM3D is a novel cytokine-like protein that belongs to the FAM3 family. Human FAM3D is synthesized as a 224 amino acid precursor that contains a 25 amino acid signal sequence and a 199 amino acid mature chain. FAM3D is identified based on structural, but not sequence, homology to short chain cytokines including IL-2, IL-4 and GM-CSF. FAM3 proteins are four helix bundle cytokines with four conserved cysteines in all members (FAM3A-D). FAM3B is highly expressed in alpha and beta cells of the pancreas and is being investigated as a potential contributor to beta cell death and development of Type I Diabetes.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-366)
Fournisseur:
ProSci Inc.
Description:
The EGFR subfamily of receptor tyrosine kinases is composed of EGFR, ErbB2, ErbB3 and ErbB4. The EGFR shares 43% - 44% aa sequence identity with the ECD of human EGFR subfamily. All these family members are type I transmembrane glycoproteins with an extracellular ligand binding domain. The extracellular ligand binding domain is containing two cysteine-rich domains separated by a spacer region and a cytoplasmic domain containing a membrane-proximal tyrosine kinase domain. Ligand binding could induce EGFR homodimerisation and heterodimerisation with ErbB2, resulting in cell signalling, heterodimerisation tyrosine phosphorylation and kinase activation. It can bind EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, epigen, and so on. Its signalling regulates multiple biological functions including cell proliferation, differentiation, motility, and apoptosis. EGFR can also be recruited to form heterodimers with the ligand-activated ErbB3 or ErbB4. EGFR is overexpressed in different tumours. Several anti-cancer drugs use EGFR as target.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5797P)
Fournisseur:
ProSci Inc.
Description:
ATG9B peptide is used for blocking the activity of ATG9B antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5821P)
Fournisseur:
ProSci Inc.
Description:
IDH2 peptide is used for blocking the activity of IDH2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5807P)
Fournisseur:
ProSci Inc.
Description:
IFITM1 peptide is used for blocking the activity of IFTIM1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-125)
Fournisseur:
ProSci Inc.
Description:
Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development, differentiation, growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter, GABA, acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-042)
Fournisseur:
ProSci Inc.
Description:
Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes a 164 amino acid precursor that contains a 23 amino acid signal peptide and a 141 amino acid mature protein. Human and mouse IL-31 share 24% sequence identity in the mature region. IL-31 is mainly associated with activated T cells and is preferentially expressed by type 2 helper T cells (Th2). IL-31 signals via a heterodimeric receptor complex composed of a gp130 related molecule termed IL-31RA (also GPL and GLMR) and an Oncostatin M receptor (OSM R beta ). The IL-31 receptor is constitutively expressed by keratinocytes and upregulated by IFN gamma on monocytes. GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Studies have shown that IL31 induces severe pruritis (itching) and dermatitis in transgenic mice.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-045)
Fournisseur:
ProSci Inc.
Description:
Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and beta thrombogulin ( beta TG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, beta TG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.
UOM:
1 * 50 µG
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