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Protéines et Peptides
Numéro de catalogue:
(PRSI96-168)
Fournisseur:
ProSci Inc.
Description:
E-Selectin is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein. It is transiently expressed on vascular endothelial cells in response to IL-1β and TNFα. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto). During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-α by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels. E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI96-158)
Fournisseur:
ProSci Inc.
Description:
CMRF35-like molecule 6 (CLM-6) is also known as CD300 antigen-like family member C, CMRF35-A1, Immunoglobulin superfamily member 16 (IgSF16) , CD antigen CD300c, which belongs to the CD300 family. CLM-6 contains one Ig-like V-type (immunoglobulin-like) domain. CD300a/c RNA and surface expression were downregulated after stimulation of plasmacytoid dendritic cells (pDCs) with TLR7 and TLR9 ligands. Exogenous interferon (IFN)-alpha down-regulated CD300a/c expression. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300a and CD300c are indistinguishable on the surface of NK cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI4023P)
Fournisseur:
ProSci Inc.
Description:
TSLP peptide is used for blocking the activity of TSLP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7385P)
Fournisseur:
ProSci Inc.
Description:
18 amino acids near the center of human TRIM33.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6617P)
Fournisseur:
ProSci Inc.
Description:
SPATA19 peptide is used for blocking the activity of SPATA19 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-264)
Fournisseur:
ProSci Inc.
Description:
Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5129P)
Fournisseur:
ProSci Inc.
Description:
APP peptide is used for blocking the activity of APP antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5141P)
Fournisseur:
ProSci Inc.
Description:
MATN3 peptide is used for blocking the activity of MATN3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5151P)
Fournisseur:
ProSci Inc.
Description:
Siglec11 peptide is used for blocking the activity of Siglec11 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-973)
Fournisseur:
ProSci Inc.
Description:
3-Hydroxybutyrate Dehydrogenase Type 2 belongs to the short-chain dehydrogenases/reductases (SDR) family. 3-Hydroxybutyrate Dehydrogenase Type 2 may play an important role in the peripheral utilization of 3-hydroxybutyrate. The cytoplasmic localization with its high ratio of oxidized NAD+, the NAD+ dependence and the kinetic parameters of 3-Hydroxybutyrate Dehydrogenase Type 2 make it suitable to conbert high levels of circulating 3-hydroxybutyrate into acetoacetate.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-975)
Fournisseur:
ProSci Inc.
Description:
14-3-3 Protein Epsilon acts as an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 protein epsilon binds to a large number of partners, usually by recognition of a phophoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-974)
Fournisseur:
ProSci Inc.
Description:
Peroxiredoxin 6 belongs to the thiol-specific antioxidant protein family, which is a bifunctional enzyme with two distinct active sites. Peroxiredoxin 6 is involved in redox regulation of the cell and can reduce Hydrogen peroxide and short chain organic, fatty acid, and phospholipid hydroperoxides. Peroxiredoxin 6 may regulates phospholipid turnover and protectes against oxidative injury. Peroxiredoxin 6 eases the oxidative stress and TGF-beta-induced abnormalities of human trabecular meshwork cells, it is necessary for blood vessel integrity in injured skin.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-322)
Fournisseur:
ProSci Inc.
Description:
Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-702)
Fournisseur:
ProSci Inc.
Description:
Inositol Polyphosphate 1-Phosphatase (INPP1) is a member of the inositol monophosphatase family. INPP1 is widely expressed in tissues, with highest expression levels observed in the pancreas and kidney. INPP1 is inhibited by Li+. Removing the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. INPP1 is involved in signal transduction and phosphatidylinositol signaling pathway.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-704)
Fournisseur:
ProSci Inc.
Description:
N-Acetyllactosaminide beta -1,3-N-Acetylglucosaminyltransferase (B3GNT1) is a member of the beta -1,3-N-Acetylglucosaminyltransferase family. B3GNT1 is a single-pass type II membrane protein and widely expressed in many tissues. B3GNT1 can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans. B3GNT1 is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen. It can initiate the synthesis or the elongation of the linear poly-N-acetyllactosaminoglycans.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2489P)
Fournisseur:
ProSci Inc.
Description:
IL-22 receptor peptide is used for blocking the activity of IL-22 receptor antibody.
UOM:
1 * 50 µG
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