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Protéines et Peptides
Numéro de catalogue:
(PRSI3451P)
Fournisseur:
ProSci Inc.
Description:
Caspase-4 peptide is used for blocking the activity of caspase-4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5359P)
Fournisseur:
ProSci Inc.
Description:
Swine H1N1 Nonstructural Protein 1 peptide is meant to be used as a positive control in ELISA applications to detect Swine-Origin Influenza A antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-481)
Fournisseur:
ProSci Inc.
Description:
Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1 and IL-6 by macrophages.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-557)
Fournisseur:
ProSci Inc.
Description:
Mannan-Binding Lectin Serine Protease 1 (MASP-1) belongs to the peptidase S1 family. MASP1 contains two CUB domains, one EGF-like domain, one peptidase S1 domain and two Sushi (CCP/SCR) domains. MASP1 is primarily expressed in liver. MASP1 involved in the lectin pathway of the complement, performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. MASP1 is synthesized as a zymogen and activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. MASP1 is not directly involved in complement activation but may act as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP2. MASP1 is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. MASP1 is inhibited by SERPING1 and A2M.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-175)
Fournisseur:
ProSci Inc.
Description:
Grancalcin (GCA) is a cytoplasmic granule membrane protein that contains 4 EF-hand domains. GCA is calcium-binding protein and particularly abundant in human neutrophils. GCA is highly expressed in bone marrow, and it can be detected in neutrophils and macrophages. Calcium-binding protein GCA cooperates with SRI and LCP1, so it may play a role in the adhesion of neutrophils to fibronectin. GCA also may play a role in the formation of focal adhesions.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-004)
Fournisseur:
ProSci Inc.
Description:
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis). GITRL is constitutively expressed and released as soluble form by solid tumours and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukaemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumours.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-521)
Fournisseur:
ProSci Inc.
Description:
Cerberus 1 is a secreted glycoprotein that forms disulfide-linked homodimers. It is a cytokine member of the DAN domain family of BMP antagonists that includes DAN (DAND1), Gremlin/Drm (DAND2), PRDC (Protein Related to Dan and Cerberus, DAND3), and COCO/Dante (DAND5). DAN family members contain a cysteine knot domain that is homologous to that found in other TGF-beta superfamily ligands. At the onset of gastrulation, Cerberus 1 is transiently expressed in anterior endodermal structures in response to Nodal and Shh. Cerberus 1 binds BMP-4 and Nodal and inhibits their activities. The inhibitory functions of Cerberus favor mesodermal development in the anterior region of the gastrula and suppresses posterior mesodermal differentiation. In chick and Xenopus, Cerberus 1 also regulates, but is not required for embryonic left-right polarization, neurulation, and head and heart induction.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-793)
Fournisseur:
ProSci Inc.
Description:
Neurotrimin localizes to the cell membrane and contains three Ig-like C2-type (immunoglobulin-like) domains. Neurotrimin acts as a glycosylphosphatidylinositol (GPI)-anchored neural cell adhesion molecule. Neurotrimin may promote neurite outgrowth and adhesion via homophilic and heterophilic interactions.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-024)
Fournisseur:
ProSci Inc.
Description:
Testin belongs to the prickle/espinas/testin family. Testin contains three LIM zinc-binding domains and one PET domain, TES as a scaffold protein that may have a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. In addition, TES can also as a tumor suppressor, inhibits tumor cell growth, regulate the cell proliferation.TES interacts with many cytoskeletal proteins, such as Zyxin, Mena, Actin, Talin and VASP. The ability of TES to associate with alpha-actin, Zyxin and paxillin is dependent on the conformational state of the molecule.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6229P)
Fournisseur:
ProSci Inc.
Description:
TM4SF1 peptide is used for blocking the activity of TM4SF1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-246)
Fournisseur:
ProSci Inc.
Description:
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be detected in the adult brain, liver, lung, heart, stomach, spleen and testis. It is expressed in fetal liver and adult skeletal muscle. CLIC2 is a potential candidate for one of many diseases linked to Xq28.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5465P)
Fournisseur:
ProSci Inc.
Description:
OCIAD2 peptide is used for blocking the activity of OCIAD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6395P)
Fournisseur:
ProSci Inc.
Description:
AP3B2 peptide is used for blocking the activity of AP3B2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6397P)
Fournisseur:
ProSci Inc.
Description:
TMEM88 peptide is used for blocking the activity of TMEM88 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6227P)
Fournisseur:
ProSci Inc.
Description:
TMEM192 peptide is used for blocking the activity of TMEM192 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI40-611)
Fournisseur:
ProSci Inc.
Description:
TWEAK belongs to the TNF family of ligands and signals through TWEAKR also known as TNFRSF12A. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK has the ability to induce NFkB activation and chemokine secretion, and to exert an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma cells when cultured in the presence of IFN-γ. TWEAK also promotes proliferation and migration of endothelial cells. Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein.
UOM:
1 * 25 µG
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