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Anticorps
Numéro de catalogue:
(BOSSBS-7910R-CY7)
Fournisseur:
Bioss
Description:
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).Tissue specificity:Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7911R-CY3)
Fournisseur:
Bioss
Description:
Tyrosine kinase of the non-receptor type. Probably performs an important function, perhaps in regulatory processes such as cell cycle control.Tissue specificity: Expressed in a variety of lymphoid cell lines.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3707R-HRP)
Fournisseur:
Bioss
Description:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12050R-A647)
Fournisseur:
Bioss
Description:
Serotonin (also designated 5-hydroxytryptamine or 5-HT) is a molecule that functions as a neurotransmitter, a hormone and a mitogen, and it is predominantly expressed in the gut, platelets and central nervous system (CNS). In the CNS, serotonin modulates several processes, including anxiety, sleep, appetite, behavior and drug abuse. In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9674R-CY5.5)
Fournisseur:
Bioss
Description:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9023R-A680)
Fournisseur:
Bioss
Description:
Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterised by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier. alternatively splicing events.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11626R-FITC)
Fournisseur:
Bioss
Description:
OR5T1
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11627R-A350)
Fournisseur:
Bioss
Description:
Fe65L is a 758 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the ∫-Amyloid precursor protein, Fe65L is thought to modulate the internalization and, therefore, the accessibility and function of ∫-Amyloid. Via its ability to control the intracellular accumulation of ∫-Amyloid, Fe65L is thought to play a role in the pathogenesis of Alzheimer's disease. Multiple isoforms of Fe65L exist due to alternative splicing events. The gene encoding Fe65L maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11627R-CY7)
Fournisseur:
Bioss
Description:
Fe65L is a 758 amino acid protein that contains one WW domain and two PID domains. Binding to the intracellular domain of the ∫-Amyloid precursor protein, Fe65L is thought to modulate the internalization and, therefore, the accessibility and function of ∫-Amyloid. Via its ability to control the intracellular accumulation of ∫-Amyloid, Fe65L is thought to play a role in the pathogenesis of Alzheimer's disease. Multiple isoforms of Fe65L exist due to alternative splicing events. The gene encoding Fe65L maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4030R-CY5)
Fournisseur:
Bioss
Description:
Pancreatic amylase is a digestive enzyme secreted by the pancreas. It consists of a single polypeptide chain with a molecular weight of 54 kDa.Pancreatic amylase and salivary amylase are the products of separate genes and, although they share 98% amino acid sequence homology, they differ in molecular size, isoelectric point and antigenic properties. Measurement of amylase concentrations in serum is a diagnostic test for various pancreatic disorders (especially acute and relapsing pancreatitis).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4989R-A647)
Fournisseur:
Bioss
Description:
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2201R-A555)
Fournisseur:
Bioss
Description:
GEF-H1 is a Rho guanine nucleotide exchange factor that localizes to microtubules and regulates Rho activity in response to microtubule destabilization (loss of interaction between GEF-H1 and microtubules leads to activation of Rho). This protein has also been shown to localize to tight junctions and modulate polarized cell permeability.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1342R-A488)
Fournisseur:
Bioss
Description:
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6042R-CY3)
Fournisseur:
Bioss
Description:
Shows moderate inhibition of cathepsin B but is not active against cathepsin C.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2201R-CY5)
Fournisseur:
Bioss
Description:
GEF-H1 is a Rho guanine nucleotide exchange factor that localizes to microtubules and regulates Rho activity in response to microtubule destabilization (loss of interaction between GEF-H1 and microtubules leads to activation of Rho). This protein has also been shown to localize to tight junctions and modulate polarized cell permeability.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1342R-A555)
Fournisseur:
Bioss
Description:
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.
UOM:
1 * 100 µl
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