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Bioss
Numéro de catalogue:
(BOSSBS-2225R)
Fournisseur:
Bioss
Description:
Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development. The Smad family is divided into three subclasses: receptor regulated Smads, activin/TGF beta receptor regulated (Smad2 and 3) or BMP receptor regulated (Smad 1, 5, and 8); the common partner, (Smad4) that functions via its interaction to the various Smads; and the inhibitory Smads, (Smad6 and 7). Activated Smad3 oligomerizes with Smad4 upon TGF beta stimulation and translocates as a complex into the nucleus, allowing its binding to DNA and transcription factors. Phosphorylation of the two TGF beta dependent serines 423 and 425 in the C terminus of Smad3 is critical for Smad3 transcriptional activity and TGF beta signaling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7925R)
Fournisseur:
Bioss
Description:
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly.Tissue specificity: Widely expressed. Present in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle. Also found in adult cell lines.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7921R)
Fournisseur:
Bioss
Description:
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.Involvement in disease:Defects in ROBO2 are the cause of vesicoureteral reflux type 2 (VUR2) . VUR is a complex, genetically heterogeneous developmental disorder characterized by the retrograde flow of urine from the bladder into the ureter and is associated with reflux nephropathy, the cause of 15% of end-stage renal disease in children and young adults.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7948R)
Fournisseur:
Bioss
Description:
Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glyceroN-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9043R)
Fournisseur:
Bioss
Description:
PDZD8 contains a PDZ domain. PDZ domains are protein-interaction domains that are often found in multi-domain scaffolding proteins. The function of this protein remains unknown.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7961R)
Fournisseur:
Bioss
Description:
Ankyrin is a membrane protein that mediates the attachment of the erythrocyte membrane skeleton to the plasma membrane and interacts with CD44 and inositol triphosphate. It contains three functional domains: a conserved N-terminal ankyrin repeat domain (ARD(consisting of 22–24 tandem repeats of 33 amino acids), a spectrin binding domain and a variably sized C-terminal regulatory domain. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops. It has been studied using multiple sequence alignment to determine which conserved amino acid residues are critical for folding and stability. Ankyrin-repeat proteins have been associated with a number of human diseases; most notably, the cell cycle inhibitor p16 is associated with cancer and the Notch protein is a key component of cell signaling pathways whose intracellular repeat domain is disrupted in mutations that give rise to the neurological disorder known as CADASIL.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13721R)
Fournisseur:
Bioss
Description:
The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell to cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT4 (FAT tumor suppressor homolog 4), also known as FAT-J, CDHF14 or CDHR11, is a 4,981 amino acid single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins and localizes to the primary cilia of kidney. Widely expressed, FAT4 contains thirty-four cadherin domains, six EGF-like domains and two laminin G-like domains. FAT4 may function in the regulation of planar cell polarity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13718R)
Fournisseur:
Bioss
Description:
Cadherins comprise a family of Ca++-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy-terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. Cadherin-26 is a 852 amino acid single-pass transmembrane protein containing 4 cadherin domains through which it interacts with other cadherins in a homophilic manner. There are 4 named isoforms of cadherin-26 that are produced as a result of alternative spicing events.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13703R)
Fournisseur:
Bioss
Description:
The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13712R)
Fournisseur:
Bioss
Description:
Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13710R)
Fournisseur:
Bioss
Description:
Anti-Netrin 5 Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13700R)
Fournisseur:
Bioss
Description:
Anti-SH3BGRL2 Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-4201R)
Fournisseur:
Bioss
Description:
HIF1AN (Hypoxia inducible factor 1 alpha inhibitor) is a corepressor that interacts with hypoxia inducible factor 1 (HIF1) alpha and the von Hippel Lindau tumor suppressor protein to mediate repression of HIF1 transcriptional activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5138R)
Fournisseur:
Bioss
Description:
Anti-LZTFL1 Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0018R)
Fournisseur:
Bioss
Description:
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5148R)
Fournisseur:
Bioss
Description:
Anti-CDC7 Rabbit Polyclonal Antibody
UOM:
1 * 100 µl
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