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Bioss
Numéro de catalogue:
(BOSSBS-15121R-A680)
Fournisseur:
Bioss
Description:
c21orf63
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7055R-A350)
Fournisseur:
Bioss
Description:
Fatty acid elongase specific to C12-C16 saturated and monoinsaturated fatty acids.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15200R-CY7)
Fournisseur:
Bioss
Description:
C5orf22
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6675R-A680)
Fournisseur:
Bioss
Description:
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarisation which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1041R-A750)
Fournisseur:
Bioss
Description:
MAP2K1
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyse the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6678R-A555)
Fournisseur:
Bioss
Description:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3305R-CY5.5)
Fournisseur:
Bioss
Description:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6678R-CY5.5)
Fournisseur:
Bioss
Description:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3305R-A680)
Fournisseur:
Bioss
Description:
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13343R-FITC)
Fournisseur:
Bioss
Description:
The GGA family of proteins (Golgi-localized, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin (1?). Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) (1,2,4). GGAs have modular structures with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin ear) domain (5). The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences (3). GGA1 and GGA2 do not associate with each other, but they do colocalize on perinuclear membranes (2). The cytosolic domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1 and GGA2 (6). The human GGA1 gene maps to chromosome 22 and encodes a protein that shares 45% sequence identity with GGA2 and GGA3 (1).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2464R-CY3)
Fournisseur:
Bioss
Description:
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0775R-A647)
Fournisseur:
Bioss
Description:
This clone was constructed and sequenced as part of a high-throughput process to generate expression-ready clones from the Drosophila Gene Collection for use as a proteomics resource. The clone has been full-length sequenced to verify fidelity in translation, proper reading frame and presence of a recombination site.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13343R-CY5)
Fournisseur:
Bioss
Description:
The GGA family of proteins (Golgi-localized, ARF-binding proteins) are ubiquitous coat proteins that facilitate the trafficking of soluble proteins from the trans-Golgi network (TGN) to endosomes/lysosomes by means of interactions with TGN-sorting receptors, ARF (ADP-ribosylation factor), and clathrin (1?). Members of the GGA family, GGA1,GGA2 (also known as VEAR) and GGA3, are multidomain proteins that bind mannose 6-phosphate receptors (MPRs) (1,2,4). GGAs have modular structures with an N-terminal VHS (VPS-27, Hrs, and STAM) domain followed by a GAT (GGA and TOM1) domain, a connecting hinge segment, and a C-terminal GAE (?adaptin ear) domain (5). The amino-terminal VHS domains of GGAs form complexes with the cytoplasmic domains of sorting receptors by recognizing acidic-cluster di-leucine (ACLL) sequences (3). GGA1 and GGA2 do not associate with each other, but they do colocalize on perinuclear membranes (2). The cytosolic domain of memapsin 2, but not that of memapsin 1, binds the VHS domains of GGA1 and GGA2 (6). The human GGA1 gene maps to chromosome 22 and encodes a protein that shares 45% sequence identity with GGA2 and GGA3 (1).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-0699R-A555)
Fournisseur:
Bioss
Description:
Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:9096318). Negatively regulates BMP signaling (PubMed:25402622).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2464R-A350)
Fournisseur:
Bioss
Description:
Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6257R-HRP)
Fournisseur:
Bioss
Description:
Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.
UOM:
1 * 100 µl
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