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Bioss
Numéro de catalogue:
(BOSSBS-2921R-CY5)
Fournisseur:
Bioss
Description:
Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15062R-FITC)
Fournisseur:
Bioss
Description:
C1orf228
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3892R-HRP)
Fournisseur:
Bioss
Description:
Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3893R-A350)
Fournisseur:
Bioss
Description:
May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nuceleolar architecture is observed.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7843R-CY3)
Fournisseur:
Bioss
Description:
NUP160 is 1 of up to 60 proteins that make up the 120 MD nuclear pore complex, which mediates nucleoplasmic transport. NUP160 forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. NUP160 is involved in poly(A)+ RNA transport.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7843R-CY5)
Fournisseur:
Bioss
Description:
NUP160 is 1 of up to 60 proteins that make up the 120 MD nuclear pore complex, which mediates nucleoplasmic transport. NUP160 forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. NUP160 is involved in poly(A)+ RNA transport.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6671R-A680)
Fournisseur:
Bioss
Description:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6671R-FITC)
Fournisseur:
Bioss
Description:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3300R-CY5)
Fournisseur:
Bioss
Description:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3300R-A750)
Fournisseur:
Bioss
Description:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15191R-CY3)
Fournisseur:
Bioss
Description:
C4orf3
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15063R-A750)
Fournisseur:
Bioss
Description:
C1orf229
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6672R-A350)
Fournisseur:
Bioss
Description:
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12068R-A647)
Fournisseur:
Bioss
Description:
TMEM132A is a 560 amino acid protein encoded by a gene mapping to human chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and ∫ thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8539R-A647)
Fournisseur:
Bioss
Description:
Luciferase from the firefly has become one of the more widely used reporter proteins for the study of gene expression. Luciferase catalyzes a bioluminescent reaction which requires the substrate luciferin as well as Mg2+ and ATP. Mixing these reagents with the cell extract containing luciferase, results in a flash of light that decays rapidly. This light can be detected by a luminometer. The total light emission is proportional to the luciferase activity of the sample.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-12069R-A488)
Fournisseur:
Bioss
Description:
The tetratricopeptide repeat (TPR) motif is a degenerate, 34 amino acid sequence found in many proteins and acts to mediate protein-protein interactions in various pathways. At the sequence level, there can be up to 16 tandem TPR repeats, each of which has a helix-turn-helix shape that stacks on other TPR repeats to achieve ligand binding specificity. TTC21B (tetratricopeptide repeat domain 21B), also known as THM1, is a 1,316 amino acid protein that contains 19 TPR repeats and belongs to the TTC21 family. Localizing to cytoplasm and cytoskeleton, TTC21B exists as two alternatively spliced isoforms and is thought to negatively regulate Shh signal transduction. TTC21B may also be involved in retrograde intraflagellar transport in cilia, and is encoded by a gene that maps to human chromosome 2q24.3.
UOM:
1 * 100 µl
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