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Bioss
Numéro de catalogue:
(BOSSBS-3069R-A680)
Fournisseur:
Bioss
Description:
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilisation, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defence. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7764R-A680)
Fournisseur:
Bioss
Description:
NUSAP1 is a microtubule-associated protein with the capacity to bundle and stabilise microtubules. It may associate with chromosomes and promote the organisation of mitotic spindle microtubules around them. There are five different isoforms.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11326R-A488)
Fournisseur:
Bioss
Description:
Probable regulator of calmodulin signaling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11326R-FITC)
Fournisseur:
Bioss
Description:
Probable regulator of calmodulin signaling.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3945R-A350)
Fournisseur:
Bioss
Description:
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7764R-FITC)
Fournisseur:
Bioss
Description:
NUSAP1 is a microtubule-associated protein with the capacity to bundle and stabilize microtubules. It may associate with chromosomes and promote the organization of mitotic spindle microtubules around them. There are five different isoforms.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7764R-HRP)
Fournisseur:
Bioss
Description:
NUSAP1 is a microtubule-associated protein with the capacity to bundle and stabilize microtubules. It may associate with chromosomes and promote the organization of mitotic spindle microtubules around them. There are five different isoforms.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2972R-CY7)
Fournisseur:
Bioss
Description:
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2972R-A750)
Fournisseur:
Bioss
Description:
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15099R-A750)
Fournisseur:
Bioss
Description:
Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf166 gene product has been provisionally designated C20orf166 pending further characterisation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-10221R-CY5)
Fournisseur:
Bioss
Description:
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013].
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-2974R-CY3)
Fournisseur:
Bioss
Description:
Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9628R-A555)
Fournisseur:
Bioss
Description:
C16orf44 is a 616 amino acid protein that contains six Kelch repeats, one BTB/POZ domain and one BTB/Kelch associated (BACK) domain. C16orf44 is believed to play a role in protein ubiquitination and may function as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, C16orf44 interacts with CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Due to alternative splicing events, two isoforms of C16orf44 are expressed.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11721R-CY7)
Fournisseur:
Bioss
Description:
Transcriptional repressor which may play a role in development of the central nervous system (CNS).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11877R-A488)
Fournisseur:
Bioss
Description:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM2 (leucine rich repeat transmembrane neuronal 2), also known as LRRN2, is a 516 amino acid single-pass type I membrane protein involved in the development maintenance of the vertebrate nervous system. Expressed in kidney and neuronal tissues, LRRTM2 contains ten LRR repeats and belongs to the LRRTM family. LRRTM2 is encoded by a gene that maps to human chromosome 5q31.2.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-8307R-HRP)
Fournisseur:
Bioss
Description:
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.
UOM:
1 * 100 µl
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