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Bioss
Numéro de catalogue:
(BOSSBS-4162R-A750)
Fournisseur:
Bioss
Description:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1168R-A555)
Fournisseur:
Bioss
Description:
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1168R-A647)
Fournisseur:
Bioss
Description:
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1168R-CY5.5)
Fournisseur:
Bioss
Description:
High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3864R-A680)
Fournisseur:
Bioss
Description:
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3866R-CY5.5)
Fournisseur:
Bioss
Description:
Protor-1 plays an important role in regulation of PDGF receptor expression and in modulation of PDGF signaling. It is thought that Protor-1 may act as a tumor suppressor in breast cancer.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3866R-A555)
Fournisseur:
Bioss
Description:
Protor-1 plays an important role in regulation of PDGF receptor expression and in modulation of PDGF signaling. It is thought that Protor-1 may act as a tumor suppressor in breast cancer.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3866R-CY3)
Fournisseur:
Bioss
Description:
Protor-1 plays an important role in regulation of PDGF receptor expression and in modulation of PDGF signaling. It is thought that Protor-1 may act as a tumor suppressor in breast cancer.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11110R-A350)
Fournisseur:
Bioss
Description:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH17 is a 1,159 amino acid single-pass type I membrane protein that contains six cadherin domains. Expressed as multiple alternatively spliced isoforms, PCDH17 is thought to function as a calcium-dependent cell adhesion protein that may play a role in establishing cell-cell connections within brain tissue. The gene encoding PCDH17 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1110R-A680)
Fournisseur:
Bioss
Description:
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15348R-HRP)
Fournisseur:
Bioss
Description:
Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. The C9orf93 gene product has been provisionally designated C9orf93 pending further characterisation. There are two isoforms of C9orf93 that are produced as a result of alternative splicing events.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1110R-A488)
Fournisseur:
Bioss
Description:
Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15046R-A647)
Fournisseur:
Bioss
Description:
C1orf186
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15046R-FITC)
Fournisseur:
Bioss
Description:
C1orf186
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7103R-HRP)
Fournisseur:
Bioss
Description:
THAP1 contains a THAP domain, a zinc-dependent DNA-binding domain. It colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies and is a pro-apoptopic protein that potentiates both serum-withdrawal and TNF-induced apoptosis. It is a physiologic regulator of endothelial cell proliferation and cell-cycle progression, two essential processes for angiogenesis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-1545R-FITC)
Fournisseur:
Bioss
Description:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodelling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
UOM:
1 * 100 µl
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