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Bioss


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Numéro de catalogue: (BOSSBS-11869R-A680)

Fournisseur:  Bioss
Description:   Leukocyte cell-derived chemotaxin 2 (LECT2) is a secreted protein with a neutrophil chemotactic activity. LECT2 is highly expressed in liver and shows diffuse immunostaining within the cytoplasm of hepatocytes. The LECT2 protein consists of 133 amino acids and three intramolecular disulfide bonds, and homologues of LECT2 have been widely identified in many vertebrates. LECT2 has a multifunctional role that extends from cell growth, differentiation, damage/repair process and carcinogenesis to autoimmune diseases. LECT2 expression is specifically induced in liver by catenin Signalling. Serum LECT2 levels have been shown to increase in response to liver recovery, suggesting LECT2 may be used as a prognostic indicator.
UOM:  1 * 100 µl

Fournisseur:  Bioss
Description:   Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-8245R-CY7)

Fournisseur:  Bioss
Description:   Important role in the capacity of milk to transport calcium phosphate.Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-11870R-A488)

Fournisseur:  Bioss
Description:   During development, genetically distinct subtypes of motor neurons express unique combinations of LIM-type homeodomain factors, which regulate cell migration and guide motor axons to establish the fidelity of a binary choice in axonal trajectory. The LIM gene family encodes a set of gene products, which carry the LIM domain, a unique cysteine-rich zinc-binding domain. At least 40 members of this family have been identified in vertebrates and invertebrates, and are distributed into 4 groups according to the number of LIM domains and to the presence of homeodomains and kinase domains. The human LHX5 gene maps to chromosome 12q23-q24 and encodes a 402 amino acid protein. The hippocampus contains the neural circuitry, which is crucial for cognitive functions such as learning and memory. LHX5 regulates precursor cell proliferation and neuronal differentiation and migration during hippocampal development.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-8245R-A350)

Fournisseur:  Bioss
Description:   Important role in the capacity of milk to transport calcium phosphate.Casoxin D acts as opioid antagonist and has vasorelaxing activity mediated by bradykinin B1.
UOM:  1 * 100 µl

Fournisseur:  Bioss
Description:   NCAPG2 is 1 of 3 non-SMC subunits that define condensin II. Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 and SMC4, but they contain different sets of non-SMC subunits. NCAPG2 is 1 of 3 non-SMC subunits that defines condensin II.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-1646R-CY5)

Fournisseur:  Bioss
Description:   The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-3831R-A350)

Fournisseur:  Bioss
Description:   Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-3409R-CY5.5)

Fournisseur:  Bioss
Description:   This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008].
UOM:  1 * 100 µl

Fournisseur:  Bioss
Description:   This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008].
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-7582R-A680)

Fournisseur:  Bioss
Description:   BCL2L15.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-6179R-A350)

Fournisseur:  Bioss
Description:   Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-13669R-CY5)

Fournisseur:  Bioss
Description:   Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-0829R-CY3)

Fournisseur:  Bioss
Description:   Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-13748R-A350)

Fournisseur:  Bioss
Description:   Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
UOM:  1 * 100 µl
Numéro de catalogue: (BOSSBS-6178R-A750)

Fournisseur:  Bioss
Description:   Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.
UOM:  1 * 100 µl
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