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Bioss
Numéro de catalogue:
(BOSSBS-5681R-HRP)
Fournisseur:
Bioss
Description:
Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5682R-CY5)
Fournisseur:
Bioss
Description:
Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine/threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c Fos and CREB.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13229R-A488)
Fournisseur:
Bioss
Description:
FUSIP1 is a member of the Serine/Arginine (SR) family of splicing factors. Members of the SR family all contain one or more RNA recognition motifs (RRM) and an SR-rich domain. SR factors are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. Expressed in a variety of tissues with low expression in kidney, liver and heart, FUSIP1 localizes to the cytoplasm and nuclear speckles. In its dephosphorylated form (occurring during M phase of the cell cycle), FUSIP1 functions as a potent general repressor of pre-mRNA splicing and can interact with U1 SnRNP 70. In its phosphorylated form, FUSIP1 interacts with Tra-2∫ and, together, they may cooperate in the regulation of splicing. Four isoforms exist for FUSIP1. In neurons, FUSIP1 isoforms may act to either positively or negatively regulate alternative splicing.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-13229R-FITC)
Fournisseur:
Bioss
Description:
FUSIP1 is a member of the Serine/Arginine (SR) family of splicing factors. Members of the SR family all contain one or more RNA recognition motifs (RRM) and an SR-rich domain. SR factors are not only essential for constitutive splicing but also regulate splicing in a concentration-dependent manner by influencing the selection of alternative splice sites. Expressed in a variety of tissues with low expression in kidney, liver and heart, FUSIP1 localizes to the cytoplasm and nuclear speckles. In its dephosphorylated form (occurring during M phase of the cell cycle), FUSIP1 functions as a potent general repressor of pre-mRNA splicing and can interact with U1 SnRNP 70. In its phosphorylated form, FUSIP1 interacts with Tra-2∫ and, together, they may cooperate in the regulation of splicing. Four isoforms exist for FUSIP1. In neurons, FUSIP1 isoforms may act to either positively or negatively regulate alternative splicing.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15549R-CY5)
Fournisseur:
Bioss
Description:
IFI27.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-3767R-A350)
Fournisseur:
Bioss
Description:
Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity).
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-11428R-CY5)
Fournisseur:
Bioss
Description:
Neuropeptides are regulators of synaptic transmission and their effects are mediated by G-protein coupled receptors. NPS (Neuropeptide S) is a 20 amino acid peptide cleaved from a larger precursor that contains a hydrophobic signal peptide and proteolytic cleavage processing sites. The N-terminal residue of NPS is always a serine regardless of the species. NPS is predominantly found in the central nervous system and plays an important role regulating sleep/wake functions, locomotion, arousal/anxiety responses and food intake. NPS functions by binding and activating its receptor, NPSR, and increasing intracellular calcium levels thereby acting as an excitatory transmitter. In addition, NPS stimulates the hypothalamo-pituitary adrenal (HPA) axis via the release of corticotropin-releasing factor (CRF) and arginine vasopressin (AVP). NPS and its receptor NPSR may also play a role in asthma pathogenesis.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-15549R-CY3)
Fournisseur:
Bioss
Description:
IFI27.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7868R-FITC)
Fournisseur:
Bioss
Description:
KLHL8 contains 1 BTB (POZ) domain, and 6 Kelch repeats. Its precise function is still unknown.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-7830R-CY3)
Fournisseur:
Bioss
Description:
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-14278R-A750)
Fournisseur:
Bioss
Description:
GTPase activator activity.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9094R-A488)
Fournisseur:
Bioss
Description:
AHNAK2 contains 1 PDZ (DHR) domain. There are 3 named isoforms of AHNAK2 produced by alternative splicing. AHNAK2 is a 600-kDa protein composed of a large number of highly conserved repeat segments. AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9682R-A350)
Fournisseur:
Bioss
Description:
C19orf46 is a 404 amino acid single-pass type IV membrane protein that belongs to the nesprin family. C19orf46 partcipates in the establishment of secretory epithelial morphology by inducing kinesin-dependent apical migration of the centrosome and Golgi apparatus as well as basal localization of the nucleus. C19orf46 interacts with UKHC and KCL1, and exists as two alternatively spliced isoforms. C19orf46 contains a KASH domain, which consists of a transmembrane motif, mediates nuclear enevelop targeting and binds to the SUN domain of SUN1 and SUN2. C19orf46 is encoded by a gene located on human chromosome 19, which consists of approximately 63 million bases and makes up over 2% of human genomic DNA.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9093R-A750)
Fournisseur:
Bioss
Description:
AIM1L.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-5241R-HRP)
Fournisseur:
Bioss
Description:
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-9093R-CY3)
Fournisseur:
Bioss
Description:
AIM1L
UOM:
1 * 100 µl
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