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ProSci Inc.
Numéro de catalogue:
(PRSIXW-7950)
Fournisseur:
ProSci Inc.
Description:
FUNCTION: Functions in synaptic vesicle exocytosis. Associated with the docking/fusion complex crucial to transmitter release. Regulate the sequential interactions of beta-SNAP and synaptotagmins with the SNAP receptor during exocytosis. Binds syntaxin.
SIMILARITY: Belongs to the complexin/synaphin family. TISSUE SPECIFICITY: Nervous system.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-961)
Fournisseur:
ProSci Inc.
Description:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-960)
Fournisseur:
ProSci Inc.
Description:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-975)
Fournisseur:
ProSci Inc.
Description:
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-7979)
Fournisseur:
ProSci Inc.
Description:
DNAL4 belongs to the dynein light chain family. It’s force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-970)
Fournisseur:
ProSci Inc.
Description:
Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-7866)
Fournisseur:
ProSci Inc.
Description:
Proteins of the large Rab GTPase family have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RCP is one of many proteins that interact with and regulate Rab GTPases.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-7187)
Fournisseur:
ProSci Inc.
Description:
Estrogen receptor 1; estrogen receptor 1 (beta). Estrogen receptor (ER) has two distinct isoforms, beta and beta. ER, the steroid receptor, belongs to a large superfamily of ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI80-022)
Fournisseur:
ProSci Inc.
Description:
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI80-037)
Fournisseur:
ProSci Inc.
Description:
Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and enhances suppression of cellular proliferation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI30-641)
Fournisseur:
ProSci Inc.
Description:
The function of this gene is not known, but its existence is supported by mRNAs and EST data. A similar gene in mice was found to be expressed preferentially in hematopoietic progenitors and mature blood cells.The function of this gene is not known, but its existence is supported by mRNAs and EST data. A similar gene in mice was found to be expressed preferentially in hematopoietic progenitors and mature blood cells. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI30-658)
Fournisseur:
ProSci Inc.
Description:
ZNF618 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 4 C2H2-type zinc fingers. ZNF618 may be involved in transcriptional regulation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI30-656)
Fournisseur:
ProSci Inc.
Description:
TCEAL2 is a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner.This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5077)
Fournisseur:
ProSci Inc.
Description:
LRFN4 Antibody: LRFN4 is one of a family of five transmembrane glycoproteins that are highly expressed in neuronal tissues. LRFN proteins share leucine-rich repeat (LRR)-immunoglobulin-like (Ig)-fibronectin type III (Fn)-transmembrane domain structure with other members of the LRR-Ig-Fn protein superfamily such as the Slitrk family of proteins. Expression of LRFN1, -3, and -4 mRNA was detected in embryonic neuronal cells, while Lrfn2 and Lrfn5 expression was primarily restricted to more mature cells. LRFN1, -2, and -4 bound to PDZ domains of postsynaptic PSD95, re-distributing PSD95 to the cell periphery. It has been suggested that the Lrfn proteins play a role in the developing and/or mature vertebrate nervous system. At least two isoforms of LRFN4 are known to exist.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI27-293)
Fournisseur:
ProSci Inc.
Description:
Although C1orf25 is similar to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms, the true function of C1orf25 protein is not known.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5071)
Fournisseur:
ProSci Inc.
Description:
PCDH12 Antibody: Protocadherins comprise the largest group within the cadherin family of calcium-dependent cell-cell adhesion molecules. Protocadherin 12 (PCDH12) was initially identified through PCR screening of mouse heart microvascular endothelial cell RNA; further experiments revealed its mRNA to be strongly expressed in highly vascularized organs such as lung and kidney, in addition to glycogen-rich trophoblasts in the placenta. PCDH12-null mice are viable and fertile, but show reduced placental and embryonic sizes when compared to wild-type mice. Further studies showed significant expression changes in 2, 289 genes, including those involved in tissue morphogenesis, angiogenesis, cell-matrix adhesion and migration, immune response and chromatin remodeling.
UOM:
1 * 1 EA
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